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ClinicalTrials.gov public records Last synced Oct 14, 2026, 2:59 AM EDT

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Showing 457–480 of 951 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Bupivacaine HCL Clear all
Completed Phase 4 Interventional Results available

The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block

NCT01272921
View directory record Official record
Conditions
The Duration of Motor Block May Vary Between 12-36 Hrs
Interventions
Bupivacaine, Ropivacaine
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 75 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Oct 14, 2026, 2:59 AM EDT
Withdrawn Phase 3 Interventional

Transversus Abdominis Plane (TAP) Block for Post Caesarian Pain

NCT01986049
View directory record Official record
Conditions
Obstetrical Complications From Sedation During Parturition
Interventions
Bupivicaine
Drug
Lead sponsor
New York Presbyterian Brooklyn Methodist Hospital
Other
Eligibility
18 Years to 50 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Oct 14, 2021 · Synced Oct 14, 2026, 2:59 AM EDT
Recruiting Phase 4 Interventional

Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

NCT05824832
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Interscalene block with the addition of buprenorphine, clonidine, dexamethasone, Interscalene block with buprenorphine alone
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Regional TAP Block for Bariatric Patients

NCT04051684
View directory record Official record
Conditions
Bariatric Surgery, Transverse Abdominal Plane Regional Blocks
Interventions
Transverse abdominal plane block, Ropivacaine
Procedure · Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Oct 14, 2026, 2:59 AM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Study Evaluating Sphenopalatine Ganglion Block (SPGB) for Treatment of Postdural Puncture Headache (PDPH)

NCT02365909
View directory record Official record
Conditions
Postdural Puncture Headache
Interventions
0.5% bupivacaine, normal saline
Drug
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Oct 14, 2026, 2:59 AM EDT
Not yet recruiting Phase 4 Interventional

Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy

NCT06709716
View directory record Official record
Conditions
Postoperative Pain, Laparoscopic Hysterectomy, Nerve Block, Quadratus Lumborum Block
Interventions
Quadratus Lumborum Block (QLB), Quadratus lumborum block, Local Anesthetic Solution
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Phase 4 Interventional Results available

QL Block With Exparel in Colectomy

NCT03827291
View directory record Official record
Conditions
Laparotomy, Colectomy
Interventions
Exparel, Thoracic epidural analgesia
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 14, 2026, 2:59 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

The Association Between Decreasing Labor Analgesia Epidural Infusion and Forceps Delivery

NCT00443560
View directory record Official record
Conditions
Labor Pain, Pregnancy
Interventions
Case controlled analysis of epidural labor analgesia patterns
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
2,162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 14, 2014 · Synced Oct 14, 2026, 2:59 AM EDT
Recruiting Phase 4 Interventional

Cryo Rib Fracture Study

NCT06347874
View directory record Official record
Conditions
Rib Fractures
Interventions
Cryoablation, ESP Catheter
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain

NCT03854344
View directory record Official record
Conditions
Pain, Postoperative, Burns
Interventions
Lidocaine Hydrochloride, Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 14, 2026, 2:59 AM EDT
Terminated Phase 1 Interventional

Liposomal Bupivacaine Pharmacokinetic Study After Median Sternotomy Incision Infiltration in a Pediatric Cardiac Surgery

NCT04685421
View directory record Official record
Conditions
Cardiac Conditions
Interventions
Bupivacaine liposome
Drug
Lead sponsor
Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Other
Eligibility
2 Years to 17 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Phase 3 Interventional Results available

Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride

NCT03270514
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Artery Stenoses, Valve Regurgitation, Mitral, Valve Regurgitation, Tricuspid
Interventions
Exparel Injectable Product, Bupivacaine Hydrochloride
Drug
Lead sponsor
Kathirvel Subramaniam
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 5, 2021 · Synced Oct 14, 2026, 2:59 AM EDT
Terminated Phase 4 Interventional Results available

A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B302

NCT01507233
View directory record Official record
Conditions
Bowel Obstruction
Interventions
IV morphine sulfate, EXPAREL (bupivacaine liposome injectable suspension)
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 6, 2014 · Synced Oct 14, 2026, 2:59 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Exparel vs. ACB With Bupivacaine for ACL Reconstruction

NCT06274008
View directory record Official record
Conditions
ACL Tear, Opioid Misuse, Pain, Anxiety
Interventions
Exparel
Drug
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
7 Years to 17 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2024 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Phase 2 Interventional Results available

Selective Intraoperative Administration of Local Anesthesia in Breast Reconstruction

NCT02525718
View directory record Official record
Conditions
Breast Cancer
Interventions
Saline, 0.25 % bupivacaine (2.5 mg/ml) w/ 1:100,000 epinephrine & 4 mg dexamethasone
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 79 Years · Female only
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 14, 2026, 2:59 AM EDT
Not yet recruiting Phase 4 Interventional

A Study Of Stellate Ganglion Blockade With Liposomal Bupivacaine In Preventing Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting Surgery

NCT07570940
View directory record Official record
Conditions
Coronary Artery Disease, Atrial Fibrillation
Interventions
Liposomal bupivacaine, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Not applicable Interventional Results available

High Pain Intervention in Cesarean Sections

NCT01298778
View directory record Official record
Conditions
Other Chronic Postoperative Pain
Interventions
Duramorph 150, Acetaminophen, Duramorph 300
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Oct 14, 2026, 2:59 AM EDT
Enrolling by invitation Phase 3 Interventional Accepts healthy volunteers

Efficacy of Liposomal Bupivacaine Post Septorhinoplasty

NCT05964868
View directory record Official record
Conditions
Rhinoplasty, Pain Management
Interventions
Liposomal Bupivacaine, 0.25% bupivacaine with 1:200,000 epinephrine, Placebo - Saline solution
Drug · Other
Lead sponsor
Jessyka Lighthall
Other
Eligibility
18 Years to 99 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Not applicable Interventional

Ultrasound-Guided Block of the Lateral Femoral Cutaneous Nerve in Pediatric Patients

NCT01500655
View directory record Official record
Conditions
Burns
Interventions
Regional nerve block, Catheter
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
2 Years to 21 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 6, 2016 · Synced Oct 14, 2026, 2:59 AM EDT
Not listed Not applicable Interventional

Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arthroplasty (TKA)

NCT02060591
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Exparel, Marcaine
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 12, 2014 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Phase 3 Interventional

An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries

NCT04785638
View directory record Official record
Conditions
Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy, Colectomy, Reduction Mammoplasty
Interventions
INL-001 (bupivacaine hydrochloride) implant
Combination Product
Lead sponsor
Innocoll
Industry
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
8
States / cities
Florence, Alabama • Sheffield, Alabama • Pasadena, California + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Oct 14, 2026, 2:59 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

NCT03119038
View directory record Official record
Conditions
Osteoarthritis, Degenerative Joint Disease
Interventions
Bupivicaine + epinephrine, Bupivacaine, Ropivacaine, Ketorolac, Clonidine Injection
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Oct 14, 2026, 2:59 AM EDT
Completed Phase 2 Interventional Results available

Pharmacokinetics, Relative Bioavailability and Safety of Xaracoll Implant

NCT02232178
View directory record Official record
Conditions
Hernioplasty
Interventions
2 100mg Xaracoll implants, 3 100mg Xaracoll implants, 150mg Bupivacaine HCl injection
Drug
Lead sponsor
Innocoll
Industry
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
5
States / cities
Anniston, Alabama • Sheffield, Alabama • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2020 · Synced Oct 14, 2026, 2:59 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Stopping Opioid Overuse in Obstetrics to Halt Exposure Trial

NCT04680221
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use
Interventions
Liposomal bupivacaine, TAP block, Deposition of saline
Drug · Procedure
Lead sponsor
University of Missouri, Kansas City
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Oct 14, 2026, 2:59 AM EDT