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Conditions: Postoperative Pain
Interventions: Exparel, Bupivacaine hydrochloride, Patient Controlled Analgesia (PCA); Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 350 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Interventions: Mepivacaine, Bupivacaine; Drug
Lead sponsor: Prisma Health-Upstate; Other
Eligibility: 18 Years and older
Enrollment: 138 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: CREST Syndrome, Peripheral Vascular Disease, Raynaud Disease, Scleroderma, Diffuse
Interventions: liposomal bupivacaine; Drug
Lead sponsor: Jose Soberon, MD; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Postherpetic Neuralgia, Pain
Interventions: Transdermal/Patch (Bupivacaine TTS [Eladur™]); Drug
Lead sponsor: Durect; Industry
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 7
States / cities: La Jolla, California • Loma Linda, California • Santa Monica, California + 4 more

Conditions: Breast Neoplasm
Interventions: Ultrasound, 0.25% bupivacaine; Device · Drug
Lead sponsor: Huntington Memorial Hospital; Other
Eligibility: 18 Years to 85 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Pasadena, California

Conditions: Kidney Transplantation
Interventions: TAP block, liposomal bupivacaine plus free bupivacaine, normal saline; Procedure · Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 224 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Anesthesia, Local, Pain, Postoperative
Interventions: Short-term ON-Q, Short-term ON-Q, Long-term ON-Q, Long-term ON-Q; Device · Drug
Lead sponsor: AdventHealth; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Herniorrhaphy, Postoperative Pain, Inguinal Hernia
Interventions: Bupivacaine Collagen Sponge, Placebo collagen Sponge; Drug
Lead sponsor: Innocoll; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Bellaire, Texas

Conditions: Inguinal Hernia, Pain
Interventions: SEMPERFLO Pain Management System, ON-Q PainBuster Post-Op Pain Relief System; Device
Lead sponsor: Ethicon, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 6
States / cities: Boca Raton, Florida • Jacksonville, Florida • St Louis, Missouri + 3 more

Conditions: Pain Management Strategies in Liver Resection Surgery
Interventions: thoracic epidural, continuous paravertebral catheter, Patient-Controlled Analgesia; Device · Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Labor Pain
Interventions: No Basal Infusion, Basal infusion, PCEA solution (bupivacaine and fentanyl); Other · Drug
Lead sponsor: Neil Roy Connelly, MD; Other
Eligibility: 18 Years to 45 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Springfield, Massachusetts

Conditions: Acute Pain
Interventions: liposomal bupivacaine, Bupivacaine; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 75 Years · Female only
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Pain, Postoperative, ACL
Interventions: OxyCODONE 5 mg Oral Tablet, Naproxen 500 Mg, Tylenol Pill, Liposomal bupivacaine, Femoral Nerve Catheter; Drug · Procedure
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions: Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline; Drug
Lead sponsor: John O'Toole; Other
Eligibility: 18 Years to 80 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Obesity, Morbid, Surgery, Bariatric Surgery Candidate
Interventions: Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product, Oxycodone Hydrochloride, Hycet 7.5Mg-325Mg/15Ml Solution, Zofran Injection, Scopolamine patch, Ativan, Flexeril Oral Product, Tylenol Suspension; Drug
Lead sponsor: University of California, Davis; Other
Eligibility: 35 Years to 65 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Post Operative Pain
Interventions: Bupivacaine, normal saline 0.9%; Drug
Lead sponsor: The Christ Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 128 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 3
States / cities: Kansas City, Kansas • Cincinnati, Ohio • Toledo, Ohio

Conditions: Pain
Interventions: SKY0402, Bupivacaine HCl; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 136 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 15
States / cities: Birmingham, Alabama • Mobile, Alabama • La Jolla, California + 10 more

Conditions: Hip Fractures
Interventions: PENG block and cryoablation, fascia iliaca compartment block; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 85 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Migraine
Interventions: Saline, lidocaine/bupivacaine; Drug · Combination Product
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Encephalomyelitis, Myalgic, Chronic Fatigue Syndrome, Chronic Fatigue Disorder, Chronic Fatigue and Immune Dysfunction Syndrome, Myalgic Encephalomyelitis, Postviral Fatigue Syndrome, Systemic Exertion Intolerance Disease, Infectious Mononucleosis-Like Syndrome, Chronic, Chronic Fatigue-Fibromyalgia Syndrome
Interventions: Bupivacaine Injection; Drug
Lead sponsor: Neuroversion, Inc.; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Anchorage, Alaska

Conditions: Neonatal Neurobehavior, Breastfeeding Outcomes
Interventions: Bolus 10mL 0.25% bupivacaine/ep 1:600,000; infusion 10mL/hour 0.25% bupivacaine and epi 1:800,000, Bolus 10mL 0.25% bupivacaine/ epinephrine 1:600,000;infusion 10mL/hour 0.25% bupivacaine, 2 mcg/mL fentanyl, and epinephrine 1:800,000, Bolus 10mL 0.25% bupivacaine, 10mcg/mL fentanyl, and epi 1:600,000; infusion 10mL/hour 0.25% bupivacaine, 2.5 mcg/mL fentanyl, and epi 1:800,000, Bolus 10mL 0.25% bupivacaine, 5 mcg/mL fentanyl, and epi 1:600,000; infusion 10mL/hour 0.25% bupivacaine, 3.5 mcg/mL fentanyl, and epi 1:800,000; Drug
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Osteoarthritis, Knee
Interventions: Intracapsular Injection, Periarticular Injection; Procedure
Lead sponsor: Broward Health; Other
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Fort Lauderdale, Florida

Conditions: Knee Pain
Interventions: Genicular nerve block with bupivacaine and corticosteroids, Standard of Care; Procedure · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 4
States / cities: Philadelphia, Pennsylvania

Conditions: Total Knee Replacement, Postoperative Pain
Interventions: Bupivacaine HCl, F14 (celecoxib); Drug
Lead sponsor: Arthritis Innovation Corporation; Industry
Eligibility: 45 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 3
States / cities: Denver, Colorado • Dayton, Ohio • San Antonio, Texas

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PAIN - Postoperative Analgesia INvestigation

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

Exparel as a Nerve Block for Severe Hand Pain

Study of a Bupivacaine Patch (Eladur™) to Treat Post- Herpetic Neuralgia

Effect of Pectoral Nerve Block on Post-op Pain in Patients Undergoing Mastectomy and Immediate Reconstruction

Does an Abdominal Wall Nerve Block During Surgery Help Reduce Pain From Kidney Transplantation?

Pain Management After TKA: Comparison of Short- and Long-term Nerve Blocks

Safety and Efficacy of CollaRx® Bupivacaine Implant in Men After Open Laparotomy Herniorrhaphy

SEMPERFLO* Pain Management System in Inguinal Hernia Repair

TEA vs. PVB vs. PCA in Liver Resection Surgery

Parturient Controlled Epidural Analgesia (PCEA) With or Without a Basal Infusion for Early Labor

Pec Infiltration With Liposomal Bupivacaine for Breast Surgery

Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Multimodal Analgesia Effect on Post Surgical Patient

A Trial of Levator Muscle Blocks Following Posterior Colporrhaphy Surgery to Reduce Post-operative Pain.

Phase 3 Study of Local Administration of SKY0402 for Postoperative Analgesia in Subject Undergoing Breast Augmentation

Comparison of Cryoablation of Pericapsular Nerve Group (PENG) to Fascia Iliaca Catheter in Patients With a Hip Fracture

A Research Study of Greater Occipital Nerve Block as a Treatment for Acute Migraine Attacks

Effect of Stellate Ganglion Block on ME/CFS

Intrapartum Epidural Fentanyl and Breastfeeding in the Immediate Postpartum Period: a Randomized, Controlled, Double-blinded Study

Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty

Genicular Nerve Block for Knee Pain in the ED

Safety and Activity of F14 for Management of Pain Following Total Knee Replacement