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ClinicalTrials.gov public records Last synced Oct 14, 2026, 10:05 AM EDT

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Showing 721–744 of 951 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Bupivacaine Hydrochloride Clear all
Terminated Phase 4 Interventional Results available

PIEB vs CEI for Labor Analgesia: An MLAC Study

NCT02573597
View directory record Official record
Conditions
Pregnancy
Interventions
Bupivacaine, Sufentanil
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Oct 14, 2026, 10:05 AM EDT
Terminated Phase 4 Interventional Results available

Spinal Anesthesia in Total Hip Arthroplasty

NCT02818894
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
Lidocaine, Bupivacaine
Drug
Lead sponsor
Thomas L Bradbury
Other
Eligibility
18 Years to 90 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2022 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Efficacy of Laparoscopic-assisted Transversus Abdominus Plane (TAP) Block Compared to Ultrasound-guided TAP Block in Minimally Invasive Gynecologic Surgeries: A Prospective, Randomized Control Trial.

NCT04345341
View directory record Official record
Conditions
the Efficacy of Analgesia of Laparoscopic TAP Block in Minimally Invasive Gynecology Surgeries
Interventions
TAP block with liposomal bupivacaine and bupivacaine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Not applicable Interventional

The Effect of Combined Spinal-Epidural Analgesia on the Success of External Cephalic Version (ECV) for Breech Position

NCT00565383
View directory record Official record
Conditions
Pregnancy, Breech Presentation
Interventions
Combined spinal-epidural analgesia, Intravenous fentanyl (50mcg)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 13, 2013 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Early Phase 1 Interventional

LIA in Hip Arthroscopy Patients

NCT03070054
View directory record Official record
Conditions
Pain
Interventions
20ml 0.25% bupivacaine-epinephrine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 10, 2023 · Synced Oct 14, 2026, 10:05 AM EDT
Terminated Phase 4 Interventional Results available

Exparel in Minimally Invasive Cardiac Surgery

NCT02008370
View directory record Official record
Conditions
Cardiac Disease
Interventions
Exparel infiltration
Drug
Lead sponsor
Maimonides Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Oct 4, 2019 · Synced Oct 14, 2026, 10:05 AM EDT
Recruiting Phase 2 Interventional

Local Anesthesia for Facial Fractures

NCT06429501
View directory record Official record
Conditions
Pain Management
Interventions
Bupivacaine/Epinephrine, Saline
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 14, 2026, 10:05 AM EDT
Withdrawn Phase 4 Interventional

ABC Blocks for Cardiac Surgery

NCT05589363
View directory record Official record
Conditions
Pain
Interventions
ABC block with bupivacaine/liposomal bupivacaine, ABC block with saline
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Results available

Comparison of Local Anesthetic Infusion Pump Versus Depofoam Bupivacaine for Pain Management

NCT04284930
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Depobupivacaine, OnQ pump, 0.25% Bupivacaine
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 7, 2021 · Synced Oct 14, 2026, 10:05 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort

NCT01565512
View directory record Official record
Conditions
Prostate Cancer, Robotic Prostatectomy, Foley Catheter Discomfort
Interventions
Bupivacaine, Saline
Drug
Lead sponsor
Columbia University
Other
Eligibility
40 Years to 80 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2015 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Continuous Adductor Canal Block (CACB) vs. Combined Spinal Epidural (CSE) in Total Knee Arthroplasty

NCT02415465
View directory record Official record
Conditions
Arthroplasty
Interventions
Continuous Adductor Canal Block, General, Epidural, Spinal
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 15, 2016 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Results available

Pecs II Block Versus Surgeon Infiltration for Open Subpectoral Biceps Tenodesis

NCT04867369
View directory record Official record
Conditions
Tendonitis
Interventions
Bupivacaine 20mL 0.5%, Bupivacaine 20mL 0.25%, Bupivacaine up to 15mL 0.25%
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 13, 2024 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Phase 2 Interventional

Postoperative Pain Control in Children Undergoing Laparoscopic Appendectomy: Peripheral Nerve Block Versus Local Anesthetic

NCT01662401
View directory record Official record
Conditions
Postoperative Pain
Interventions
Bupivacaine
Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
6 Years to 18 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 2, 2013 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Results available

Erector Spinae Plane Block Versus Conventional Analgesia in Complex Spine Surgery

NCT04156581
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative
Interventions
Bupivacaine, Dexamethasone, Saline
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 14, 2026, 10:05 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Liposomal Bupivacaine With Dexamethasone for Foot Surgery

NCT06465992
View directory record Official record
Conditions
Foot Surgery, Ankle Surgery, Post Operative Pain, Popliteal Nerve Block
Interventions
Exparel 266 MG Per 20 ML Injection, Bupivacaine Hcl 0.75% Inj, Dexamethasone
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Oct 14, 2026, 10:05 AM EDT
Not listed Phase 4 Interventional

Pain Relief After Hiatal Hernia Repair Surgery

NCT04936711
View directory record Official record
Conditions
Shoulder Pain, Hiatal Hernia
Interventions
Resteck Shiatsu Neck and Back Massager, Marcaine
Device · Drug
Lead sponsor
Norton Thoracic Institute
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Oct 14, 2026, 10:05 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison of the Post-C/S Analgesic Effects of Neuraxial Duramorph vs Bilateral TAP Block With Liposomal Bupivacaine

NCT03638011
View directory record Official record
Conditions
Caesarean Section
Interventions
Exparel
Drug
Lead sponsor
Maimonides Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 14, 2026, 10:05 AM EDT
Terminated Phase 4 Interventional Results available

Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty

NCT03182933
View directory record Official record
Conditions
Pain
Interventions
Peripheral Nerve Blockade, 10 meter walk test on post-operative day 1, In person and over the phone questionnaire, Force transduction of quadriceps strength
Drug · Behavioral · Other + 1 more
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Determination of the Duration of Action of a Lidocaine and a Bupivacaine Digital Nerve Block in Human Volunteers

NCT01508832
View directory record Official record
Conditions
Onset and Duration of a Digital Nerve Block
Interventions
Lidocaine Digital Nerve Block, Bupivacaine Digital Block
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Oct 14, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

PENG vs Femoral Block for Hip Fracture Analgesia

NCT07073209
View directory record Official record
Conditions
Hip Fractures
Interventions
PENG Block Administration, Femoral Block Administration, Bupivacaine , epinephrine Dexamethasone
Procedure · Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
352 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Manhattan, New York
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Early Phase 1 Interventional

Stellate Ganglion Nerve Block in Treating Women With Hot Flashes

NCT00879164
View directory record Official record
Conditions
Hot Flashes
Interventions
bupivacaine hydrochloride, questionnaire administration
Drug · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 17, 2014 · Synced Oct 14, 2026, 10:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash

NCT02619409
View directory record Official record
Conditions
Arthropathy of Hip, Arthropathy of Knee
Interventions
Bupivacaine Only, EPI25, EPI50 group, EPI75 group, EPI100 group
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Oct 14, 2026, 10:05 AM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

Preoperative Nerve Block for Rhinoplasty/Septoplasty

NCT03780478
View directory record Official record
Conditions
Nasal Fracture, Deviated Nasal Septum
Interventions
Nerve block, Placebo Saline Injection
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2019 · Synced Oct 14, 2026, 10:05 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES

NCT05688943
View directory record Official record
Conditions
Anesthesia, Tubal Ligation
Interventions
Spinal Anesthesia, General Anesthesia
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Oct 14, 2026, 10:05 AM EDT