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ClinicalTrials.gov public records Last synced Nov 15, 2026, 8:35 AM EST

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Showing 25–48 of 272 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Bupivacaine Only Clear all

Conditions: Surgical Procedures, Operative
Interventions: Dexmedetomidine, Remifentanil, Bupivacaine, Ropivacaine; Drug
Lead sponsor: Murdoch Childrens Research Institute; Other
Eligibility: 1 Month to 12 Months
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 4
States / cities: Cincinnati, Ohio • Portland, Oregon • Dallas, Texas + 1 more

Conditions: Analgesia
Interventions: Epidural Catheter for Analgesia; Device
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Postoperative Pain
Interventions: HTX-011, Luer Lock applicator, Vial access device, aprepitant; Drug · Device
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 78 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Postoperative Pain
Interventions: Subpleural pain catheter with infusion of 0.125% bupivacaine, Standard acute pain management; Drug
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years and older
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Falls Church, Virginia

Conditions: Total Knee Arthroplasty
Interventions: Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL; Procedure
Lead sponsor: The Cleveland Clinic; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Postoperative Pain
Interventions: SKY0402, Bupivacaine HCl; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 4
States / cities: San Clemente, California • Miami, Florida • Houston, Texas + 1 more

Conditions: Cesarean Section Complications, Pain, Opioid Use
Interventions: Liposomal bupivacaine, Bupivacaine Hydrochloride, saline; Drug · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Madison, Wisconsin

Conditions: Vaginismus
Interventions: BOTOX; Biological
Lead sponsor: Plastic Surgery Professional Association; Other
Eligibility: 20 Years to 40 Years · Female only
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Manchester, New Hampshire

Conditions: Osteoarthritis
Interventions: Bupivacaine, Morphine, Methylprednisolone, Cefazolin, Normal saline, Midazolam, Propofol, Dexamethasone, 8 MHz. Chiba needle, 22 G / 4 inches; Drug · Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Postoperative Pain, Pelvic Organ Prolapse, Trigger Point Injection, Sacrospinous Ligament Fixation
Interventions: marcaine and kenalog; Drug
Lead sponsor: Kettering Health Network; Other
Eligibility: 21 Years and older · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Dayton, Ohio

Conditions: Anesthesia
Interventions: Exparel, 0.25% bupivacaine; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 40 Years to 80 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Post Operative Pain, Acute
Interventions: Bupivacaine 0.25% Injectable Solution, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Buprenorphine 300 mcg; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Pontiac, Michigan

Conditions: C-Section, Pain Management
Interventions: Exparel + Bupivacaine, Bupivacaine; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 186 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 12
States / cities: Loma Linda, California • Stanford, California • Boston, Massachusetts + 7 more

Conditions: Pregnancy
Interventions: Ultrasound, No ultrasound, Epidural infusion; Device · Procedure
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 48 Years · Female only
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Pain After Carpal Tunnel Release
Interventions: Bupivacaine, Exparel; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 89 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Ankle Fractures
Interventions: Regional anesthesia group, Local multimodal analgesia group; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years to 80 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2028
U.S. locations: 2
States / cities: Salt Lake City, Utah

Conditions: Postoperative Pain
Interventions: Low Dose SKY0402, High Dose SKY0402, Placebo, Fentanyl via PCA, Bupivacaine via epidural; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 5
States / cities: Pasadena, California • Orlando, Florida • Houston, Texas + 1 more

Conditions: Pain, Postoperative, Postoperative Hemorrhage
Interventions: Bupivacaine, Fibrin Sealant; Drug · Biological
Lead sponsor: Indiana University; Other
Eligibility: 1 Year to 12 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Rib Fractures
Interventions: hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%, bupivicaine 0.5%; Drug · Procedure
Lead sponsor: Anthony Iacco; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Hemorrhoids
Interventions: Bupivacaine HCl, SKY0402; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 204 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 20
States / cities: Birmingham, Alabama • Montgomery, Alabama • Pasadena, California + 16 more

Conditions: Pain, Postoperative
Interventions: Liposomal bupivacaine, Bupivacain, Epinephrin; Drug
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 86 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: San Diego, California

Conditions: Postoperative Pain
Interventions: Liposomal bupivacaine, Standard of care; Drug · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 2
States / cities: Madison, Wisconsin

Conditions: Postoperative Pain, Inguinal Hernia
Interventions: Bupivacaine Collagen Sponge, placebo collagen sponge; Drug
Lead sponsor: Innocoll; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Anaheim, California

Conditions: Pain
Interventions: EXPAREL, Bupivacaine; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older · Male only
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 17
States / cities: Fremont, California • Loma Linda, California • Fort Lauderdale, Florida + 13 more

Search by objective public record fields.

The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.

Epidural Anesthesia /Analgesia Versus PCA for Laparoscopic Complex Ventral Hernia Repair: A Randomized Controlled Trial

Phase 2 Bunionectomy HTX-011 Administration Study

Continuous Subpleural Infusion of Bupivacaine

Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

Phase 2 Dose-Ranging Study of SKY0402 for Prolonged Postoperative Analgesia in Subject Undergoing Hemorrhoidectomy

Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control

Botox Injection for Treatment of Vaginismus

The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)

The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation

0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka

Serratus Anterior Plane Block With and Without Adjuvants in Video-assisted Thoracoscopy

Evaluate the Safety and Efficacy of EXPAREL When Administered Via Infiltration Into the TAP vs. Bupivacaine Alone in Subjects Undergoing Elective C-Sections

Does Ultrasound Help Junior Anesthesia Residents With Placement of Labor Analgesia in Pregnant Patients

Comparison of Bupivacaine and Exparel for Carpal Tunnel Release

Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractures

Dose Finding Posterolateral Thoracotomy Study

Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage

Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures

Study to Evaluate Postoperative Analgesia in Subjects Undergoing Hemorrhoidectomy

Multimodal Orthognathic Study Comparing Use of Exparel With Standard of Care.

Optimizing Recovery in Abdominoplasty

Efficacy, Safety and Pharmacokinetic Profile of a Collagen Bupivacaine Implant in Men After Open Mesh Herniorrhaphy

Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty