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ClinicalTrials.gov public records Last synced Oct 6, 2026, 12:45 AM EDT

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Showing 1–24 of 69 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Bupivacaine liposome suspension Clear all
Completed Phase 4 Interventional Results available

EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair

NCT01801124
View directory record Official record
Conditions
Hernia
Interventions
EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

EXPAREL for Minimally Invasive Supracervical Hysterectomies

NCT03769714
View directory record Official record
Conditions
Pain
Interventions
Saline Solution for Injection, Exparel
Drug
Lead sponsor
Maimonides Medical Center
Other
Eligibility
35 Years to 75 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Exparel Versus Bupivacaine in Post-operative Pain Control

NCT06547255
View directory record Official record
Conditions
Liposomal Bupivacaine
Interventions
Bupivacaine liposome injectable suspension
Drug
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 6, 2026, 12:45 AM EDT
Enrolling by invitation Phase 4 Interventional

Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery

NCT07584915
View directory record Official record
Conditions
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Interventions
Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA)
Procedure · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 6, 2026, 12:45 AM EDT
Enrolling by invitation Phase 2Phase 3 Interventional

Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain

NCT06077422
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use, Perioperative Complication, Heart Diseases
Interventions
bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 6, 2026, 12:45 AM EDT
Withdrawn Phase 4 Interventional

Bupivacaine Liposomal Injectable Suspension, Pain and Narcotic Use After Elective Orthognathic Surgery

NCT03318757
View directory record Official record
Conditions
Orthognathic Surgery
Interventions
Bupivacaine Extended Release Liposome Injection, Bupivacaine HCl
Drug
Lead sponsor
Boston University
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 11, 2020 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Not applicable Interventional Results available

Exparel Transversus Abdominis Plane Block vs Intrathecal Analgesia In Colorectal Surgery

NCT02356198
View directory record Official record
Conditions
Conditions Requiring Colorectal Surgery
Interventions
EXPAREL, Intrathecal hydromorphone
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 7, 2019 · Synced Oct 6, 2026, 12:45 AM EDT
Recruiting Not applicable Interventional

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

NCT06471348
View directory record Official record
Conditions
Post Operative Pain, Spinal Fusion
Interventions
Bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride and Epinephrine Injection
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
10 Years to 17 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Oct 6, 2026, 12:45 AM EDT
Terminated Phase 4 Interventional

Liposomal Bupivacaine Infiltration vs Continuous Perineural Ropivacaine Infusion for Post-operative Pain After Total Shoulder Arthroplasty

NCT02787226
View directory record Official record
Conditions
Postoperative Pain, Shoulder Arthritis
Interventions
Liposomal Bupivacaine Infiltration, Continuous Perineural Ropivicaine Infusion
Drug
Lead sponsor
Eric Shepard
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2018 · Synced Oct 6, 2026, 12:45 AM EDT
Active, not recruiting Phase 3 Interventional

A Study of TLC590 for Postsurgical Pain Following Bunionectomy

NCT07222748
View directory record Official record
Conditions
Postoperative Pain
Interventions
TLC590, Liposomal Bupivacaine, Saline Placebo
Drug
Lead sponsor
TLC Biopharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Miami, Florida • Bellaire, Texas • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2026 · Synced Oct 6, 2026, 12:45 AM EDT
Terminated Phase 4 Interventional Results available

Exparel vs. Standard Bupivicaine for Abdominoplasty

NCT01853176
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Liposomal Injection Bupivacaine (Exparel), Standard bupivicaine
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 3, 2014 · Synced Oct 6, 2026, 12:45 AM EDT
Active, not recruiting Phase 2 Interventional

EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement

NCT05044468
View directory record Official record
Conditions
Malignant Pleural Neoplasm
Interventions
Lidocaine, Liposomal Bupivacaine, Questionnaire Administration
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies

NCT04258631
View directory record Official record
Conditions
Malignant Female Reproductive System Neoplasm
Interventions
Hydromorphone, Laparotomy, Liposomal Bupivacaine, Questionnaire Administration
Drug · Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 3 Interventional Results available

Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy

NCT01802411
View directory record Official record
Conditions
Posterolateral Thoracotomy, Postoperative Pain
Interventions
EXPAREL 266 mg, Placebo
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
7
States / cities
Miami, Florida • Shreveport, Louisiana • Fargo, North Dakota + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2021 · Synced Oct 6, 2026, 12:45 AM EDT
Terminated Phase 4 Interventional Results available

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

NCT02353754
View directory record Official record
Conditions
Pain
Interventions
Intrathecal morphine injection, EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
5
States / cities
Port Saint Lucie, Florida • Minneapolis, Minnesota • New Brunswick, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2021 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional Results available

Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair

NCT03541941
View directory record Official record
Conditions
Analgesia, Postoperative
Interventions
Exparel, Bupivacaine Hcl 0.25% Inj, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 1 Interventional

Study to Evaluate the Pharmacokinetics and Safety of EXPAREL Administered as a Pectoral Plane Block in Women Undergoing Breast Augmentation

NCT04293809
View directory record Official record
Conditions
Breast Augmentation
Interventions
Exparel Injectable Product, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Bellaire, Texas
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional Results available

Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy

NCT02199574
View directory record Official record
Conditions
Pain
Interventions
EXPAREL
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Oct 6, 2026, 12:45 AM EDT
Terminated Phase 4 Interventional Results available

The Effect of EXPAREL® on Postsurgical Pain, and the Use of Narcotics

NCT03290196
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
EXPAREL 1.3 % in 20 ML Injection
Drug
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 72 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 6, 2026, 12:45 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Exparel vs. ACB With Bupivacaine for ACL Reconstruction

NCT06274008
View directory record Official record
Conditions
ACL Tear, Opioid Misuse, Pain, Anxiety
Interventions
Exparel
Drug
Lead sponsor
Children's Hospital of Orange County
Other
Eligibility
7 Years to 17 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2024 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery

NCT02052557
View directory record Official record
Conditions
Post-operative Pain, Colon Cancer, Diverticulitis
Interventions
Bupivacaine, Bupivacaine liposome suspension
Drug
Lead sponsor
Des Moines University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 8, 2021 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional

Pain Control in Bariatric Patients: EXPAREL(R) vs. the On-Q(R) Pain Ball

NCT02142829
View directory record Official record
Conditions
Obesity
Interventions
EXPAREL, On-Q Pain Ball
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Oct 6, 2026, 12:45 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Transverse Abdominal Plane Anesthesia for Abdominal Wall Reconstruction

NCT02274077
View directory record Official record
Conditions
Hernia, Ventral
Interventions
EXPAREL, Normal Saline
Drug
Lead sponsor
Chester Mays
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2016 · Synced Oct 6, 2026, 12:45 AM EDT
Completed Phase 4 Interventional

Extended Delivery of Bupivacaine Study in Herniorrhaphy

NCT04102267
View directory record Official record
Conditions
Analgesia
Interventions
Bupivacaine liposome injectable suspension, Bupivacaine HCl without epinephrine via continuous infusion
Drug
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Anaheim, California
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 6, 2026, 12:45 AM EDT