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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:36 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 289–312 of 459 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: CBT alone Clear all

Conditions: Insomnia, Shift-Work Related Sleep Disturbance
Interventions: Cognitive Behavioral Therapy for Insomnia for Firefighters (CBT-I-F), Fitbit Inspire HR Wrist Worn Device (NCT04176926); Behavioral · Device
Lead sponsor: Pacific University; Other
Eligibility: 18 Years and older
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Forest Grove, Oregon

Conditions: Psychological Stress, Mindfulness
Interventions: Mindfulness; Behavioral
Lead sponsor: Carnegie Mellon University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 137 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 3
States / cities: Pittsburgh, Pennsylvania • University Park, Pennsylvania

Conditions: Cystic Fibrosis, Anxiety, Depression
Interventions: UPLIFT, Treatment as usual; Behavioral
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 13 Years and older
Enrollment: 85 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2022
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Cocaine-Related Disorders
Interventions: D-Amphetamine 30mg, D-Amphetamine 60mg, Modafinil 200mg, Modafinil 400mg, Therapy, Placebo; Drug · Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 55 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Colon Adenocarcinoma, Stage IIA Colon Cancer AJCC v7, Stage IIB Colon Cancer AJCC v7, Stage IIC Colon Cancer AJCC v7, Stage IIIA Colon Cancer AJCC v7, Stage IIIB Colon Cancer AJCC v7, Stage IIIC Colon Cancer AJCC v7
Interventions: Bevacizumab, Fluorouracil, Leucovorin Calcium, Oxaliplatin; Biological · Drug
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years and older
Enrollment: 2,710 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Osteoarthritis, Knee
Interventions: Cognitive-Behavioral Intervention, Pain Education; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 45 Years to 85 Years
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Depression
Interventions: Fluoxetine, Relapse prevention cognitive behavioral therapy (CBT); Drug · Behavioral
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 8 Years to 17 Years
Enrollment: 144 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Hypochondriasis
Interventions: Fluoxetine, Cognitive Behavioral Therapy (CBT), Supportive Therapy, Placebo; Drug · Behavioral · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years and older
Enrollment: 195 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 2
States / cities: Boston, Massachusetts • New York, New York

Conditions: Cognitive Coping, Cancer
Interventions: Cancer Pain 101, Pharmacotherapy Informational Packet; Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Posttraumatic Stress Disorder
Interventions: Cognitive Processing Therapy-Cognitive Only; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Fort Hood, Texas

Conditions: Asthma, Insomnia
Interventions: SHUTi, Emmi; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 75 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Lumbar Spine Injury, Spinal Fusion, Frailty, Prehabilitation, Nutritional Supplementation, Functional Outcome
Interventions: Multimodal Prehabilitation, Standard Pre-Surgical Clinical Care; Other
Lead sponsor: University of Florida; Other
Eligibility: 55 Years to 85 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Sleep Architecture, Mild Traumatic Brain Injury, Sleep, Sleep and Circadian Problems
Interventions: Cognitive behavioral Therapy for insomnia (CBT-I); Behavioral
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years to 60 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Persistent Postsurgical Pain, Breast Cancer Female, Ductal Carcinoma in Situ
Interventions: Acceptance and Commitment Therapy; Behavioral
Lead sponsor: Katherine Hadlandsmyth; Other
Eligibility: 18 Years to 100 Years · Female only
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Moderate Depression
Interventions: CBT-txt; Behavioral
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 18 Years to 25 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Knoxville, Tennessee

Conditions: Suicidal Ideation, Depressive Disorder, Anxiety Disorders, Post Traumatic Stress Disorder
Interventions: Enhanced Usual Care (EUC), Problem Solving Therapy (PST) plus EUC; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 55 Years and older
Enrollment: 117 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Palo Alto, California • Syracuse, New York

Conditions: ARMS, APS, Prodromal Symptoms
Interventions: Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 12 Years to 25 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression, Insomnia
Interventions: Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Depression, Mood Monitoring; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 1,175 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Headache, Headache Disorders, Headache, Migraine, Migraine, Migraine Disorders, Migraine With Aura, Migraine Without Aura, Chronic Migraine
Interventions: CBT, Amitriptyline; Behavioral · Drug
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 10 Years to 17 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 15
States / cities: Birmingham, Alabama • Phoenix, Arizona • San Francisco, California + 12 more

Conditions: Asthma, Depression
Interventions: SAMBA, Cognitive Behavioral Therapy-Asthma Depression (CBT-AD), Original SAMBA; Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 60 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety
Interventions: Uncertainty-focused single session intervention, Maintaining a healthy lifestyle single session intervention; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 25 Years to 60 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress
Interventions: PRIDE QUIT, Enhanced Treatment As Usual (ETAU); Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 3
States / cities: Boston, Massachusetts

Conditions: Chronic Pain
Interventions: Cognitive Behavioral Therapy (CBT), Hypnotic Cognitive Therapy (HYP-CT), Mindfulness-Based Cognitive Therapy (MBCT); Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 331 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Seattle, Washington • Tacoma, Washington

Conditions: Sleep Apnea, Obstructive, Brain Injuries, Traumatic
Interventions: MI and CBT 4-session manualized intervention; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Tampa, Florida

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A Pilot Study of Cognitive Behavioral Therapy - Insomnia (CBT-I) Among Professional Firefighters

Mechanisms of Mindfulness Training and Stress Reduction

Project UPLIFT to Reduce Anxiety and Depression in CF Patients

Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals

Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer

Study of Pain Catastrophizing-2 (SPAC-2)

Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse

Treatment of Hypochondriasis With CBT and/or SSRI

Evaluating Feasibility and Acceptability of Pain Education

Variable-length Cognitive Processing Therapy for Combat-Related PTSD

Solving Insomnia Electronically: Sleep Treatment for Asthma

Does Prehabilitation Improve Outcomes in Patients Undergoing Complex Spine Fusion Surgery?

Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)

Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy

Treating Depression With Text Messaging

Reducing Suicide Risk in Older Veterans Using Problem Solving Therapy

Cognitive Behavioral Therapy for the Prevention of Paranoia in Adolescents at High Risk

Digital CBT for Insomnia and Depression

Responding With Evidence and Access for Childhood Headaches

R34 Asthma Depression

Test of Target Engagement of Ambiguity Aversion

Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

Matching Adults to Treatments for Chronic Pain (MATCH) Study

Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury