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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: CBT for Loneliness Clear all
Completed Not applicable Interventional Results available

The Association Between Loneliness and Substance Use

NCT04938492
View directory record Official record
Conditions
Opioid Use, Loneliness
Interventions
Cognitive Behavioral Therapy for loneliness (CBT-L), Physical Health Education Training (PHET)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 10, 2026, 7:47 AM EDT
Recruiting Not applicable Interventional

Fostering Agricultural Relationships and Meaning - Thriving on Kinship

NCT07218965
View directory record Official record
Conditions
Loneliness, Social Isolation, Rural Health
Interventions
Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional

iWellness Study to Evaluate a Mental Health App for Students

NCT05234970
View directory record Official record
Conditions
Depression, Anxiety
Interventions
Wysa, Harvard College App
Other
Lead sponsor
Harvard University
Other
Eligibility
18 Years and older
Enrollment
289 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Mobile App to Address Student Loneliness

NCT04164654
View directory record Official record
Conditions
Loneliness
Interventions
Loneliness Intervention
Behavioral
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 25 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 10, 2026, 7:47 AM EDT
Not listed No phase listed Observational

Combining H1-Coil Deep Transcranial Magnetic Stimulation (dTMS) and App-guided CBT in Subjects With Major Depression Disorder (MDD)

NCT04455646
View directory record Official record
Conditions
Data Collection for Facilitation of Machine Learning Algorithm for Personalized Treatment
Interventions
CBT-based, mobile-delivered, intervention platform
Behavioral
Lead sponsor
Brainsway
Industry
Eligibility
22 Years to 68 Years
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
22
States / cities
San Diego, California • Juno Beach, Florida • Palm Beach, Florida + 18 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2020 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional

Empower@Home:Connected - Feasibility and Preliminary Effect Study

NCT05732740
View directory record Official record
Conditions
Depression, Loneliness, Social Isolation, Depressive Disorder, Mood Disorders, Mental Disorder
Interventions
Empower@Home:Connected
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 1, 2023 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Results available

Substance Use and Loneliness

NCT05338268
View directory record Official record
Conditions
Substance Use Disorders
Interventions
CBT for Loneliness, CBT for Substance Use Disorder
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Decreasing Loneliness to Optimize Pain Care

NCT06285032
View directory record Official record
Conditions
Loneliness, Opioid Use
Interventions
Cognitive Behavior Therapy (CBT), Social Navigation Group, Controlled Group
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SSIs for Mental Health and Loneliness

NCT05687162
View directory record Official record
Conditions
Loneliness, Mental Health Issue, Distress, Emotional, Depression, Anxiety, Stress
Interventions
Overcoming Loneliness three-week intervention, Overcoming Loneliness single-session intervention, Single-session "Sharing Feelings" program, The Blu Surfer program: a popular online content-based intervention for psychological distress, The Action Brings Change (ABC) Program (TEAM Lab version), Online help-seeking as usual, The Lonely Blu Surfer program: a popular online content-based intervention for loneliness, Overcoming loneliness SSI 8-minute version
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
16 Years and older
Enrollment
4,370 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jul 21, 2024 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional

Social Prescribing and Relationship Cognitive Strategies (SPARCS)

NCT06656975
View directory record Official record
Conditions
Social Isolation, Suicidal Ideation
Interventions
Brief Cognitive Therapy, Social Prescribing, Enhanced Usual Care
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Brighton, Michigan • Canton, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Results available

Mindfulness to Reduce Loneliness in Older Caregivers

NCT04560088
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Mindfulness, Breathing
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Sep 10, 2026, 7:47 AM EDT
Terminated Not applicable Interventional Results available

Evaluation of a Computerized Intervention for Learning to Re-Evaluate Suicidal Thoughts

NCT04254809
View directory record Official record
Conditions
Suicidal Ideation
Interventions
Re-Evaluating Suicidal Thoughts, Healthy Social Living
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Dec 5, 2021 · Synced Sep 10, 2026, 7:47 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Occupational Therapy for Mental Health and Engagement in Neurorehabilitation

NCT07375485
View directory record Official record
Conditions
Acquired Brain Injury, Mental Health, Depressive Symptoms, Anxiety Symptoms, Loneliness
Interventions
Multifaceted implementation program
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Denver, Colorado • Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 10, 2026, 7:47 AM EDT
Recruiting Not applicable Interventional

Integrated Treatment for Enhancing Growth in Recovery During Adolescence

NCT06395467
View directory record Official record
Conditions
Alcohol Use Disorder, Cannabis Use Disorder
Interventions
InTEGRA, MET/CBT
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 21 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Farmington, Connecticut • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Combatting Social Isolation in Older Adults

NCT05426837
View directory record Official record
Conditions
Loneliness, Social Isolation
Interventions
Combatting Social Isolation, Health Education Training
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Sep 10, 2026, 7:47 AM EDT
Recruiting Not applicable Interventional

Intervening on Opioid Use and Loneliness

NCT06458335
View directory record Official record
Conditions
Opioid Use Disorder, Loneliness, Social Isolation
Interventions
Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preliminary Efficacy of a One-Session Mindfulness Telehealth Intervention for Loneliness

NCT04414826
View directory record Official record
Conditions
Loneliness
Interventions
Mindfulness Alone (MO) Intervention, Mindfulness + Compassion Intervention (MC)
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 70 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 31, 2022 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional Results available

Pain and Loneliness

NCT05455476
View directory record Official record
Conditions
Chronic Pain
Interventions
CBT for Loneliness, CBT for Chronic Pain
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Canandaigua, New York
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Sep 10, 2026, 7:47 AM EDT
Completed Not applicable Interventional

Testing the Effectiveness of an Online Behavioral Intervention in Reducing Loneliness

NCT04112225
View directory record Official record
Conditions
Psychological Distress, Loneliness
Interventions
Happify
Behavioral
Lead sponsor
Happify Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
890 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 1, 2020 · Synced Sep 10, 2026, 7:47 AM EDT