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ClinicalTrials.gov public records Last synced Oct 27, 2026, 6:53 AM EDT

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Showing 1–24 of 111 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: CBT for Substance Use Disorder Clear all
Completed Not applicable Interventional

Integrated Intervention Post-Sexual Assault

NCT04724746
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder, Sexual Assault
Interventions
Written Exposure and Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2024 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional

An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder

NCT06102200
View directory record Official record
Conditions
Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
Interventions
CBT4CBT, RC, Sandard of care
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Not yet recruiting Not applicable Interventional

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

NCT07714200
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Phase 4 Interventional Results available

N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use

NCT04627922
View directory record Official record
Conditions
Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
Interventions
N-Acetyl cysteine, Placebo comparator, Cognitive behavioral therapy (CBT)
Drug · Other · Behavioral
Lead sponsor
Ellen Herbst
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Results available

Tailored Response to Psychiatric Comorbidity to Improve HIV Care Engagement in the United States

NCT04163341
View directory record Official record
Conditions
HIV/AIDS, Depression, Anxiety, Post-traumatic Stress Disorder, Substance Use Disorders
Interventions
Adapted Common Elements Treatment Approach
Behavioral
Lead sponsor
Michael J Mugavero, MD
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

NCT02513069
View directory record Official record
Conditions
Smoking, Veterans
Interventions
Nicotine gum, mobile contingency management, Telephone counseling, Nicotine patch, Nicotine lozenge, Smart phone, Carbon monoxide monitor
Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2020 · Synced Oct 27, 2026, 6:53 AM EDT
Active, not recruiting Not applicable Interventional

CBT-I to Improve Functional Outcomes in Veterans With Psychosis

NCT04646200
View directory record Official record
Conditions
Insomnia, Psychosis
Interventions
Cognitive Behavioral Therapy-Insomnia, Health and Wellness
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Baltimore, Maryland • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Active, not recruiting Not applicable Interventional

Examining Feasibility and Acceptability of Telemedicine for Substance Use Disorder (SUD)

NCT04768920
View directory record Official record
Conditions
Substance Use Disorders, Substance Use, Substance Dependence
Interventions
MI-CBT Teletx
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional

Use of Technological Advances to Prevent Smoking Relapse Among Smokers With PTSD

NCT01990079
View directory record Official record
Conditions
PTSD, Smoking
Interventions
Bupropion, nicotine replacement therapy, Smoking cessation counseling, mobile contingency management, Stay Quit Coach
Drug · Other · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Results available

Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder

NCT05042388
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
Mindfulness-Based Relapse Prevention - Rolling Admission (MBRP-RA), Treatment-As-Usual
Behavioral
Lead sponsor
West Chester University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
West Chester, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Recruiting Not applicable Interventional

Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

NCT06654414
View directory record Official record
Conditions
Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress
Interventions
PRIDE QUIT, Enhanced Treatment As Usual (ETAU)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 27, 2026, 6:53 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Designing a Mobile App for Veterans With Substance Use Problems

NCT01812187
View directory record Official record
Conditions
Substance Abuse Problem, Alcohol Abuse, Alcohol Dependence
Interventions
SHIFT Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Michael E. DeBakey VA Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2015 · Synced Oct 27, 2026, 6:53 AM EDT
Not yet recruiting Not applicable Interventional

Recovery Works - Facilitating Sustainable Recovery Through Workforce

NCT07216612
View directory record Official record
Conditions
Substance Use Disorder (SUD)
Interventions
Community Restitution Apprenticeship-Focused Training (CRAFT), Standard Employment Model
Other
Lead sponsor
West Virginia School of Osteopathic Medicine
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lewisburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project IntERact Study

NCT03940716
View directory record Official record
Conditions
Violence, Substance Use, Criminal Behavior
Interventions
IntERact
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
16 Years to 24 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Flint, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ACT with NMOSD Patients and Caregivers Pilot Study

NCT05840055
View directory record Official record
Conditions
NMO Spectrum Disorder
Interventions
Acceptance and Commitment Therapy
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 7, 2025 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Collaborative Care for Alcohol Use Disorders in the Patient-centered Medical Home

NCT02885311
View directory record Official record
Conditions
Alcohol-Related Disorders, Alcohol Drinking, Alcoholism, Alcohol Abuse, Alcohol Use Disorders
Interventions
Motivation Enhancement Therapy, Modified Behavioral Self-Control Therapy, Naltrexone, Brief Advice, Referral to specialty substance use disorder treatment
Behavioral · Drug · Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 75 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional

Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence

NCT02461732
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Dependence
Interventions
Treatment for Integrated Posttraumatic Stress and Substance Use (TIPSS), Cognitive-Behavioral Therapy for Substance Dependence
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Phase 1 Interventional

Computer-Based Training in Cognitive Behavior Therapy (CBT4CBT)

NCT01406899
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
Computer Based Treatment
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Newington, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 23, 2014 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

NCT00307203
View directory record Official record
Conditions
Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders
Interventions
bupropion SR, Cognitive Behavioral Group Therapy, nicotine replacement therapy
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users

NCT01614106
View directory record Official record
Conditions
HIV, AIDS, Substance Abuse
Interventions
Retention Clinic
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
2
States / cities
Miami, Florida • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 12, 2022 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CBT4CBT-Buprenorphine + Recovery Coach for Office-based Buprenorphine

NCT04824404
View directory record Official record
Conditions
Opioid-use Disorder
Interventions
CBT4CBT-Buprenorphine + Recovery Coach
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 1, 2024 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Results available

SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)

NCT00265564
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 7, 2020 · Synced Oct 27, 2026, 6:53 AM EDT
Completed Not applicable Interventional Results available

Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders

NCT01338506
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
Interventions
Concurrent Treatment with Prolonged Exposure (COPE)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Oct 27, 2026, 6:53 AM EDT
Active, not recruiting Not applicable Interventional

Using the Ending Self-Stigma Intervention to Reduce Internalized Stigma Among People Living With HIV Who Use Substances

NCT05704764
View directory record Official record
Conditions
HIV, Stigma, Social, Substance Use
Interventions
Ending Self Stigma for Persons living with HIV and Use Substances
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Newhall, California • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 27, 2026, 6:53 AM EDT