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ClinicalTrials.gov public records Last synced Oct 21, 2026, 7:09 AM EDT

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Showing 1–24 of 83 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: CO2 Laser Clear all
Completed Not applicable Interventional

Fractional CO2 Laser Therapy for Survivors of Breast Malignancies

NCT03307044
View directory record Official record
Conditions
Breast Carcinoma, Cancer Survivor, Cervical Carcinoma, Dyspareunia, Vaginal Dryness
Interventions
Laser Therapy, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser

NCT02357979
View directory record Official record
Conditions
Dental Caries
Interventions
Laser, Fluoride
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 21, 2026, 7:09 AM EDT
Terminated Phase 2 Interventional

S9709, Laser Surgery Plus Radiation Therapy in Treating Patients With Early Stage Cancer of the Larynx

NCT00003040
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
laser surgery, radiation therapy
Procedure · Radiation
Lead sponsor
SWOG Cancer Research Network
Network
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2007
U.S. locations
12
States / cities
Little Rock, Arkansas • Los Angeles, California • Sacramento, California + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 15, 2012 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

NCT06366503
View directory record Official record
Conditions
Photoaging, Wrinkle, Skin Laxity
Interventions
Fractional Ablative CO2 Laser, Facial Cleanser, Facial Moisturizer, Sunscreen, Basic Ointment
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Blue Ash, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 3, 2025 · Synced Oct 21, 2026, 7:09 AM EDT
Recruiting Phase 3 Interventional

Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial

NCT05379153
View directory record Official record
Conditions
Vaginal Atrophy, Breast Carcinoma
Interventions
Laser Therapy, Sham Intervention, Questionnaire Administration, Quality of Life Assessment
Device · Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
22 Years and older · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Des Moines, Iowa • Ann Arbor, Michigan • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 21, 2026, 7:09 AM EDT
Terminated Phase 2 Interventional Results available

Celebrex (Celecoxib) Treatment of Laryngeal Papilloma

NCT00592319
View directory record Official record
Conditions
Laryngeal Papilloma
Interventions
Celebrex, PDL, CO2 laser or microsurgery
Drug · Device · Procedure
Lead sponsor
Boston University
Other
Eligibility
18 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2012 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Results available

Fractionated Carbon Dioxide Laser and Burn Scar Contractures: Evaluation of Post-Treatment Scar Function and Appearance

NCT02115646
View directory record Official record
Conditions
Burn Scars
Interventions
fractionated carbon dioxide laser
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
5 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced Oct 21, 2026, 7:09 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military

NCT04058132
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5%, Neuropsychological Assessments, Gadolinium contrast infusion, Blood sample collection for research purposes, Structural brain Magnetic Resonance Imaging (MRI
Drug · Device · Other + 1 more
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 55 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 21, 2026, 7:09 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

In-vivo Analysis of a Fractional CO2 Laser System (eMatrixCO2) Intended for Treatment of Soft Tissue

NCT01026662
View directory record Official record
Conditions
Abdominoplasty
Interventions
Ablation and skin resurfacing, eMatrixCO2
Procedure · Device
Lead sponsor
Syneron Medical
Industry
Eligibility
20 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2009
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Oct 21, 2026, 7:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Comparative Study Using Dermabrasion vs CO2 Laser & Collagen Dressing vs Vaseline Gauze in MKTP

NCT02038257
View directory record Official record
Conditions
Vitiligo, Depigmented Scars, Depigmentation
Interventions
MKTP (melanocyte keratinocyte transplant procedure), Collagen Dressing, Vaseline Impregnated Gauze, Carbon Dioxide Laser, Dermabrasion
Procedure · Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 21, 2026, 7:09 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

NCT04737616
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
CO2 laser, OCT
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Efficacy Study of GLYC-101 to Evaluate Outcomes After Post-laser Ablation

NCT00656474
View directory record Official record
Conditions
Wounds
Interventions
Placebo gel, GLYC-101 gel (1.0 %)
Drug
Lead sponsor
TR Therapeutics
Industry
Eligibility
25 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Oct 21, 2026, 7:09 AM EDT
Not yet recruiting Not applicable Interventional

Intraoperative CO₂ (Carbon Dioxide)

NCT07592468
View directory record Official record
Conditions
Wound Edges
Interventions
CO2 Fractionated Laser, Non CO2 Laser Treatment
Device · Procedure
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years to 89 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing

NCT02163746
View directory record Official record
Conditions
Hidradenitis Suppurativa
Interventions
CO2 (carbon dioxide) laser, Surgical Deroofing
Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
13 Years to 100 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 21, 2026, 7:09 AM EDT
Terminated Phase 4 Interventional Results available

RECELL to Promote Healing Following Carbon Dioxide (CO2) Laser Treatment in Cosmetic Patients

NCT05386368
View directory record Official record
Conditions
Carbon Dioxide Laser, Photoaging
Interventions
ReCell
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 99 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

LASER Pilot Project

NCT05966636
View directory record Official record
Conditions
Acquired Absence of Lower Limb, Scar Condition and Fibrosis of the Skin
Interventions
Fractional CO2 Laser Ablative Resurfacing
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Miami, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Surgical Scar Treatment With the Pulsed Dye Laser in Combination With a CO2 Laser

NCT02898350
View directory record Official record
Conditions
Scars
Interventions
Pulsed dye laser treatment, CO2 laser treatment, Combined PDL and CO2 laser treatment, Split PDL and CO2 Laser treatment
Device
Lead sponsor
Syneron Medical
Industry
Eligibility
18 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
2
States / cities
Englewood, Colorado • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 14, 2016 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MonaLisa Touch Randomized Double-Blind Placebo Controlled Study

NCT03331328
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
MonaLisa Touch
Device
Lead sponsor
Michigan Institution of Women's Health PC
Other
Eligibility
Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 21, 2026, 7:09 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Fractional CO2 Laser for the Treatment of Lichen Planus Pigmentosus

NCT05170308
View directory record Official record
Conditions
Lichen Planus Pigmentosus
Interventions
CO2 fractional laser
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Oct 21, 2026, 7:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Fractional CO2 Laser Therapy Versus 4% Topical Lidocaine Gel for Dyspareunia in Breast Cancer Survivors

NCT03257670
View directory record Official record
Conditions
Dyspareunia
Interventions
4% Topical Lidocaine Gel, CO2RE fractional laser therapy
Drug · Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Fractional Resurfacing Device for Treatment of Acne Scarring

NCT00585286
View directory record Official record
Conditions
Acne, Scar
Interventions
10,600 nm fractional carbon dioxide laser system
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jan 15, 2014 · Synced Oct 21, 2026, 7:09 AM EDT
Completed Not applicable Interventional

Effects of Pulsed Dye and CO2 Laser in Treatment of Hypertrophic Burn Scars.

NCT04769089
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
Treatment with Pulse Dye Laser, Treatment with CO2 Laser, Treatment with combination of pulse dye laser and CO2 laser., Control
Procedure · Other
Lead sponsor
The Metis Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Oct 21, 2026, 7:09 AM EDT
Completed No phase listed Observational

Histological Characterization of Vaginal Cuff Tissue Using Different Energy Sources During Robotic Hysterectomy

NCT01846858
View directory record Official record
Conditions
Extent of Thermal Injury Using Different Energy Sources at the Time of Robotic Hysterectomy Procedure
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 21, 2026, 7:09 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Histologic Evaluation of Tissue Following Lutronic System Exposure

NCT04207047
View directory record Official record
Conditions
Abdominoplasty
Interventions
Genius, eC02, PicoPlus, LaseMD, LaseMD Flex
Device
Lead sponsor
CynosureLutronic
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Billerica, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 20, 2019 · Synced Oct 21, 2026, 7:09 AM EDT