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ClinicalTrials.gov public records Last synced Oct 22, 2026, 7:04 AM EDT

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Showing 1–24 of 83 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: CO2 laser Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Burn Scar Appearance After Treatment With Fractional Carbon Dioxide (CO2) Laser

NCT00969215
View directory record Official record
Conditions
Scars
Interventions
Lumenis fractional carbon dioxide laser
Device
Lead sponsor
Moy-Fincher Medical Group
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 26, 2011 · Synced Oct 22, 2026, 7:04 AM EDT
Withdrawn Not applicable Interventional

Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser

NCT04364217
View directory record Official record
Conditions
Hypertrophic Scar, Burn Scar
Interventions
Luminis ultrapulse fractional ablative carbon dioxide laser
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Hyaluronidase Via LADD Scleroderma-induced Microstomia

NCT05995626
View directory record Official record
Conditions
Microstomia, Scleroderma
Interventions
Hyaluronidase, CO2 laser
Drug · Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
2
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional

Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar

NCT03692273
View directory record Official record
Conditions
Burns, Hypertrophic Scar
Interventions
Luminis ultrapulse fractional ablative carbon dioxide laser, 0.5mm punch biopsy
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional

Fractional CO2 Laser Therapy for Survivors of Breast Malignancies

NCT03307044
View directory record Official record
Conditions
Breast Carcinoma, Cancer Survivor, Cervical Carcinoma, Dyspareunia, Vaginal Dryness
Interventions
Laser Therapy, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Female only
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fractional CO2 Laser System (Fraxel Repair Laser) Intended for Treatment of Perioral Rhytides/Wrinkles

NCT03715049
View directory record Official record
Conditions
Wrinkle
Interventions
Fraxel Laser Treatment
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional Results available

Fractional Ablative Laser Treatment for Skin Grafts

NCT04176705
View directory record Official record
Conditions
Burn Scar, Skin Graft Scar
Interventions
Lidocaine Cream, Triamcinolone Acetonide Cream, Fractional Ablative Laser
Drug · Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Oct 22, 2026, 7:04 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vaginal Changes After CO2 Laser

NCT06691178
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
Optical coherence tomography (OCT)
Diagnostic Test
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional Results available

Evaluating the Safety and Efficacy of Fractionated Carbon Dioxide Therapy in Postoperative Lower Extremity Wound Healing

NCT03644849
View directory record Official record
Conditions
Leg Ulcer
Interventions
CO2RE® (Syneron Candela Corp, Wayland, MA), Sham laser treatment
Device · Other
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 90 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 11, 2022 · Synced Oct 22, 2026, 7:04 AM EDT
Withdrawn Phase 2 Interventional

Laser Assisted Delivery of Minoxidil in Androgenetic Alopecia

NCT03852992
View directory record Official record
Conditions
Male Pattern Hair Loss, Androgenetic Alopecia, Male Pattern Baldness
Interventions
Post-Laser Minoxidil 2%, At-Home Minoxidil 5%, Laser, Post-laser 5mg minoxidil, Post-laser 10mg minoxidil, Post-laser 20mg minoxidil
Drug · Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 65 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Laser Resurfacing Versus Dermabrasion for Scar Revision

NCT01176448
View directory record Official record
Conditions
Cicatrix, Dermabrasion, Coagulation, Laser
Interventions
Fractionated laser, Dermabrasion
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 1, 2019 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional Results available

Comparison of Vaginal Laser Therapy to Vaginal Estrogen Therapy

NCT02691936
View directory record Official record
Conditions
Atrophic Vaginitis, Menopause
Interventions
CO2 fractionated vaginal laser, Estrogens, Conjugated (USP)
Device · Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
Female only
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
6
States / cities
Stanford, California • Washington D.C., District of Columbia • Winston-Salem, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2019 · Synced Oct 22, 2026, 7:04 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

NCT04737616
View directory record Official record
Conditions
Genitourinary Syndrome of Menopause
Interventions
CO2 laser, OCT
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Phase 3 Interventional

A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia

NCT00394758
View directory record Official record
Conditions
Vulvar Dysplasia, Vaginal Dysplasia
Interventions
CO2 laser surgery, ultrasonic surgical aspiration
Procedure
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 12, 2022 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study: Evaluation of the Treatment of Striae Using Ultherapy® in Combination With Laser Treatment

NCT01810484
View directory record Official record
Conditions
Scars, Striae
Interventions
Ultherapy® treatment only, Ultherapy® treatment and CO2 laser treatment, CO2 Laser treatment only
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
21 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Paramus, New Jersey • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 31, 2018 · Synced Oct 22, 2026, 7:04 AM EDT
Recruiting Phase 3 Interventional

Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial

NCT05379153
View directory record Official record
Conditions
Vaginal Atrophy, Breast Carcinoma
Interventions
Laser Therapy, Sham Intervention, Questionnaire Administration, Quality of Life Assessment
Device · Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
22 Years and older · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Des Moines, Iowa • Ann Arbor, Michigan • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 22, 2026, 7:04 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

In-vivo Analysis of a Fractional CO2 Laser System (eMatrixCO2) Intended for Treatment of Soft Tissue

NCT01026662
View directory record Official record
Conditions
Abdominoplasty
Interventions
Ablation and skin resurfacing, eMatrixCO2
Procedure · Device
Lead sponsor
Syneron Medical
Industry
Eligibility
20 Years to 60 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2009
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Oct 22, 2026, 7:04 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Development of a Breath Analyzer for Asthma Screening

NCT00386737
View directory record Official record
Conditions
Asthma
Interventions
Not listed
Lead sponsor
Ekips Technologies
Industry
Eligibility
4 Years to 65 Years
Enrollment
2,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Norman, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 12, 2006 · Synced Oct 22, 2026, 7:04 AM EDT
Terminated No phase listed Observational

Potential Benefits of Laser Treatment on Skin Blood Flow and Sweating in Burn Survivors

NCT04947449
View directory record Official record
Conditions
Burn Injury
Interventions
fractional CO2 laser
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Timeline
2021 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 22, 2026, 7:04 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Fractional Carbon Dioxide (CO2) Laser Treatment Prior to Wound Closure

NCT00969475
View directory record Official record
Conditions
Scars
Interventions
Lumenis fractional carbon dioxide laser
Device
Lead sponsor
Moy-Fincher Medical Group
Other
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2009 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional Results available

Fractional Laser Assisted Steroid Therapy vs Intralesional Steroids in the Treatment of Keloids

NCT02996097
View directory record Official record
Conditions
Keloid
Interventions
The Lutronic electronic carbon dioxide (eCO2) Plus laser system, Intralesional Triamcinolone Acetonide
Device · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2020 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional

Effects of Pulsed Dye and CO2 Laser in Treatment of Hypertrophic Burn Scars.

NCT04769089
View directory record Official record
Conditions
Hypertrophic Scar
Interventions
Treatment with Pulse Dye Laser, Treatment with CO2 Laser, Treatment with combination of pulse dye laser and CO2 laser., Control
Procedure · Other
Lead sponsor
The Metis Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Oct 22, 2026, 7:04 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military

NCT04058132
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5%, Neuropsychological Assessments, Gadolinium contrast infusion, Blood sample collection for research purposes, Structural brain Magnetic Resonance Imaging (MRI
Drug · Device · Other + 1 more
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 55 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 22, 2026, 7:04 AM EDT
Completed Not applicable Interventional

CO2 Laser Phototherapy for Management of Mature Burn Scars

NCT03197649
View directory record Official record
Conditions
Burn Scar
Interventions
Laser phototherapy treatment
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
3 Years to 21 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2020 · Synced Oct 22, 2026, 7:04 AM EDT