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ClinicalTrials.gov public records Last synced Sep 6, 2026, 8:50 AM EDT

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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: CPAP/PEEP Clear all
Terminated Not applicable Interventional

Extubation Readiness Study in Very Low Birthweight Infants

NCT01471431
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
spontaneous breathing trial
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
48 Hours to 14 Weeks
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Phialdelphia, Pennsylvania • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Sep 6, 2026, 8:50 AM EDT
Terminated Not applicable Interventional Results available

Pediatric Helmet CPAP Pilot Study

NCT04764929
View directory record Official record
Conditions
Bronchiolitis, Viral, Pneumonia, Viral, Pneumonia, Bacterial
Interventions
Helmet CPAP
Device
Lead sponsor
Columbia University
Other
Eligibility
1 Month to 5 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema

NCT04186598
View directory record Official record
Conditions
Continuous Positive Airway Pressure, High Altitude Pulmonary Edema
Interventions
CPAP mask system, Nifedipine 30 MG, CPAP mask system without PEEP
Device · Drug
Lead sponsor
CommonSpirit Health
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Breckenridge, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Sep 6, 2026, 8:50 AM EDT
Terminated Phase 2 Interventional Results available

Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19

NCT04305457
View directory record Official record
Conditions
Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
Interventions
Nitric Oxide
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Shreveport, Louisiana • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 6, 2026, 8:50 AM EDT
Terminated Not applicable Interventional Results available

High Flow Nasal Cannula Versus Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation

NCT01270581
View directory record Official record
Conditions
Transient Tachypnea of the Newborn
Interventions
High Flow Nasal Cannula, Bubble Nasal CPAP
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
Up to 24 Hours
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2017 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional

Individualized Perioperative Open Lung Ventilatory Strategy

NCT02158923
View directory record Official record
Conditions
Moderated-high Risk of Postoperative Pulmonary Complication, Abdominal Surgery Expected More Than Two Hours
Interventions
Alveolar recruitment maneuver, Calculation of optimal PEEP, Postoperative CPAP
Procedure
Lead sponsor
Fundación para la Investigación del Hospital Clínico de Valencia
Other
Eligibility
18 Years and older
Enrollment
920 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Sep 6, 2026, 8:50 AM EDT
Withdrawn Phase 2 Interventional

Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation

NCT00793013
View directory record Official record
Conditions
Acute Lung Injury, Adult Respiratory Distress Syndrome, Kidney Injury
Interventions
Volume-Cycled Assist-Control (AC) mode, Airway Pressure Release Ventilation (APRV) mode
Device
Lead sponsor
University of Tennessee, Chattanooga
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Sep 6, 2026, 8:50 AM EDT
Not yet recruiting Not applicable Interventional

ADINA vs. High Flow Nasal Cannula Comparison Study

NCT03171129
View directory record Official record
Conditions
Respiratory Distress Neonatal
Interventions
Adaptive Dynamic Inspiratory Nasal Apparatus, High flow Nasal Canula
Device
Lead sponsor
Loma Linda University
Other
Eligibility
23 Weeks to 40 Weeks
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 6, 2026, 8:50 AM EDT
Terminated Not applicable Interventional

Acute Lung Injury Ventilator Evaluation (ALIVE)

NCT01901354
View directory record Official record
Conditions
Acute Lung Injury, Adult Respiratory Distress Syndrome
Interventions
Low-tidal-volume ventilation, Airway Pressure Release Ventilation (APRV)
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 27, 2017 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Phase 3 Interventional Results available

Surfactant Positive Airway Pressure and Pulse Oximetry Trial

NCT00233324
View directory record Official record
Conditions
Infant, Newborn, Diseases, Other Preterm Infants, Infant, Small for Gestational Age, Premature Birth, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
Interventions
Surfactant, Continuous Positive Airway Pressure (CPAP), Supplemental oxygen with target saturation of 85 to 89%, Supplemental oxygen with target saturation of 91 to 95%
Drug · Device
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
24 Weeks to 27 Weeks
Enrollment
1,316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2016
U.S. locations
22
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 18 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Phase 1Phase 2 Interventional

Delivery Room CPAP in Extremely Low Birth Weight Infants

NCT01223274
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia, Continuous Positive Airway Pressure
Interventions
CPAP/PEEP, Standard management practices
Device
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 10 Minutes
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
6
States / cities
Birmingham, Alabama • San Diego, California • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional

CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial

NCT04792099
View directory record Official record
Conditions
Infant, Newborn, Disease, Hypoxia, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Interventions
Continuous positive airway pressure, Nasal Cannula
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
Not listed
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 25, 2024 · Synced Sep 6, 2026, 8:50 AM EDT
Completed No phase listed Observational

Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.

NCT04407260
View directory record Official record
Conditions
COVID -19, Respiratory Failure, Hypoxia
Interventions
Oxygen Hood
Device
Lead sponsor
Northwell Health
Other
Eligibility
Not listed
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Sleepy Hollow, New York
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced Sep 6, 2026, 8:50 AM EDT
Withdrawn Phase 3 Interventional

Safety Study of Positive Airway Pressure Via a Nasal Mask in Obese Patients

NCT01627925
View directory record Official record
Conditions
Upper Airway Obstruction
Interventions
nasal mask and continuous positive airway pressure
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Sep 6, 2026, 8:50 AM EDT
Active, not recruiting Not applicable Interventional

Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).

NCT04372953
View directory record Official record
Conditions
Lung Injury, Preterm Birth
Interventions
Positive End-Expiratory Pressure (PEEP)
Procedure
Lead sponsor
Murdoch Childrens Research Institute
Other
Eligibility
23 Weeks to 28 Weeks
Enrollment
906 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
4
States / cities
Little Rock, Arkansas • San Diego, California • Indianapolis, Indiana + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prophylactic Continuous Positive Airway Pressure (CPAP) in Delivery Room, in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial

NCT01082900
View directory record Official record
Conditions
Transient Tachypnea
Interventions
Prophylactic CPAP Administration
Other
Lead sponsor
New York Hospital Queens
Other
Eligibility
2 Minutes to 30 Minutes
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Flushing, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2015 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional Results available

Real-time Effort Driven VENTilator Management

NCT03266016
View directory record Official record
Conditions
Ventilation Therapy; Complications, Diaphragm Disease, Pediatric Respiratory Diseases
Interventions
Computerized Ventilator Protocol, Esophageal Manometry, Respiratory Inductance Plethysmography (RIP), Diaphragm Ultrasound, Maximal Inspiratory Pressure
Other · Diagnostic Test
Lead sponsor
Children's Hospital Los Angeles
Other
Eligibility
30 Days to 18 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional Results available

Sustained Aeration of Infant Lungs Trial

NCT02139800
View directory record Official record
Conditions
Preterm Birth, Extreme Prematurity
Interventions
Sustained Inflation, Standard of Care
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
23 Weeks to 26 Weeks
Enrollment
460 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
9
States / cities
Loma Linda, California • Sacramento, California • San Diego, California + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 5, 2023 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional

Safety Study of Continuous Positive Airway Pressure Via a Nasal Mask

NCT01524614
View directory record Official record
Conditions
Upper Airway Obstruction
Interventions
nasal mask
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Sep 6, 2026, 8:50 AM EDT
Completed Not applicable Interventional Results available

Non-Contrast 4DCT to Detect Pulmonary Thromboembolic Events

NCT03183063
View directory record Official record
Conditions
Pulmonary Thromboembolisms, Pulmonary Embolism
Interventions
4DCT and SPECT/CT, 4DCT with BiPAP and SPECT/CT, 4DCT with CTA in suspected PE
Device
Lead sponsor
Thomas Guerrero
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Sep 6, 2026, 8:50 AM EDT
Recruiting Not applicable Interventional

Continued Pressure for Alveolar Protection (CPAP Trial)

NCT07417111
View directory record Official record
Conditions
Bronchopulmonary Dysplasia (BPD)
Interventions
CPAP, Nasal Cannula
Device
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 31 Weeks
Enrollment
860 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
15
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 12 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 6, 2026, 8:50 AM EDT