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ClinicalTrials.gov public records Last synced Oct 2, 2026, 5:57 AM EDT

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Showing 49–71 of 71 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: CRT implantation Clear all
Terminated Phase 3 Interventional Results available

AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study

NCT00589303
View directory record Official record
Conditions
Atrial Fibrillation, Heart Failure
Interventions
FDA approved rate and rhythm control drugs, AV Node ablation and device implant
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
65 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
5
States / cities
Scottsdale, Arizona • Evansville, Indiana • Rochester, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 2, 2026, 5:57 AM EDT
Withdrawn Early Phase 1 Interventional

Placement of CS/LV Pacing Leads With EnSite NavX Guidance

NCT00577187
View directory record Official record
Conditions
Heart Failure
Interventions
EnSite NavX-Guided CRT implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Oct 2, 2026, 5:57 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Prospective Evaluation of Elastic Restraint to LESSen the Effects of Heart Failure (PEERLESS-HF) Trial

NCT00382863
View directory record Official record
Conditions
Heart Failure
Interventions
HeartNet Ventricular Support System, Optimal Medical/Device Therapy
Device · Drug
Lead sponsor
Paracor Medical, Inc
Industry
Eligibility
18 Years to 74 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2012 · Synced Oct 2, 2026, 5:57 AM EDT
Not yet recruiting Not applicable Interventional

Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area Pacing

NCT07526896
View directory record Official record
Conditions
Heart Failure, Systolic Bundle Branch Block, Left
Interventions
LBBAP Therapy, LOT-CRT, ICD
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 2, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Model 4396 Left Ventricular (LV) Lead Study

NCT00853593
View directory record Official record
Conditions
Heart Failure
Interventions
Pacing Lead
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
19
States / cities
Pasadena, California • Sacramento, California • Atlantis, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Oct 2, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Real Time 3-Dimensional Echocardiography for Left Ventricular Lead Site Selection to Reduce Cardiac Resynchronization Therapy Non-Responder Rates

NCT01278030
View directory record Official record
Conditions
Heart Failure
Interventions
3D echo-guided LV lead placement
Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Oct 2, 2026, 5:57 AM EDT
Active, not recruiting Not applicable Interventional

Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)

NCT05541679
View directory record Official record
Conditions
Complete Heart Block, High Degree Second Degree Atrioventricular Block, Pacemaker-Induced Cardiomyopathy, Aortic Valve Stenosis
Interventions
Right ventricular septal pacing followed by left bundle branch area pacing, Left bundle branch area pacing followed by right ventricular septal pacing
Device
Lead sponsor
Main Line Health
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
Overland Park, Kansas • Ridgewood, New Jersey • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Oct 2, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Radial Strain ECHO-Guided Implantation of Cardiac Resynchronization Therapy

NCT01603706
View directory record Official record
Conditions
Ischemic Cardiomyopathy
Interventions
Echo guided implantation group
Procedure
Lead sponsor
Sheba Medical Center
Government
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Oct 2, 2026, 5:57 AM EDT
Not listed No phase listed Observational

Amyloidosis Incidence in High-Risk Cardiac Device Patients

NCT06186167
View directory record Official record
Conditions
Amyloid, Cardiac Amyloidosis, Amyloidosis Cardiac, Systemic Amyloidosis, AL Amyloidosis, Infiltrative Cardiomyopathy, Amyloid, ATTR Amyloidosis Wild Type
Interventions
Chest Wall Fat Tissue Collection
Procedure
Lead sponsor
Midwest Heart & Vascular Specialists
Other
Eligibility
40 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Oct 2, 2026, 5:57 AM EDT
Terminated No phase listed Observational

Symptomatic CRT Patients: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence

NCT05860348
View directory record Official record
Conditions
Heart Failure
Interventions
Barostim™ System
Device
Lead sponsor
CVRx, Inc.
Industry
Eligibility
Not listed
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
3
States / cities
Aurora, Colorado • Fort Lauderdale, Florida • Hackettstown, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Oct 2, 2026, 5:57 AM EDT
Completed No phase listed Observational Results available

MultiPoint Pacing™ Post Market Study

NCT02832622
View directory record Official record
Conditions
Heart Failure
Interventions
MPP, BiV/MPP
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
2,169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
110
States / cities
Birmingham, Alabama • Huntsville, Alabama • Avondale, Arizona + 99 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2021 · Synced Oct 2, 2026, 5:57 AM EDT
Completed No phase listed Observational

RISK Stratification Using a Combination of Cardiac Troponin T and Brain Natriuretic Peptide in Patients Receiving CRT-D

NCT00453622
View directory record Official record
Conditions
Heart Failure
Interventions
Cardiac Resynchronization Therapy-Defibrillator
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years to 90 Years
Enrollment
222 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Oct 2, 2026, 5:57 AM EDT
Terminated Not applicable Interventional

Vascular Endothelial Function and Cardiac Resynchronization Response in Patients With Heart Failure

NCT02783716
View directory record Official record
Conditions
Heart Failure
Interventions
Subcutaneous adipose tissue collection, Peripheral arterial tonometry (PAT)
Procedure · Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 18, 2023 · Synced Oct 2, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Correlating QLV Interval to Left Ventricular (LV) Lead Position in Patients Receiving Cardiac Resynchronization Therapy.

NCT02166762
View directory record Official record
Conditions
Heart Failure, Cardiomyopathy, Cardiac Arrhythmia
Interventions
QLV interval measurement
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2019 · Synced Oct 2, 2026, 5:57 AM EDT
Not listed Not applicable Interventional

POsition of Leads in Advanced heaRt Failure: the POLAR Study

NCT01515761
View directory record Official record
Conditions
Cardiac Resynchronization Therapy, Heart Failure
Interventions
Postero-lateral, Antero-Lateral
Procedure
Lead sponsor
Sergio Thal, M.D.
Federal
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
2
States / cities
Tucson, Arizona • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 24, 2012 · Synced Oct 2, 2026, 5:57 AM EDT
Terminated Not applicable Interventional Results available

Sentus QP - Extended CRT Evaluation With Quadripolar Left Ventricular Leads

NCT02290028
View directory record Official record
Conditions
Heart Failure
Interventions
Sentus QP left ventricular lead
Device
Lead sponsor
Biotronik SE & Co. KG
Industry
Eligibility
18 Years and older
Enrollment
2,226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
75
States / cities
Fairhope, Alabama • Anchorage, Alaska • Chula Vista, California + 64 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2021 · Synced Oct 2, 2026, 5:57 AM EDT
Terminated Phase 2 Interventional Results available

Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study

NCT04066894
View directory record Official record
Conditions
Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm, Malignant Ovarian Neoplasm, Malignant Pelvic Neoplasm, Malignant Prostate Neoplasm, Malignant Uterine Neoplasm, Malignant Vaginal Neoplasm, Malignant Vulvar Neoplasm, Rectal Carcinoma
Interventions
Explantation, Quality-of-Life Assessment, Questionnaire Administration, Sacral Nerve Stimulator, Sacral Nerve Stimulator Battery, Therapeutic Conventional Surgery
Procedure · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Houston, Texas • Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 2, 2026, 5:57 AM EDT
Completed No phase listed Observational

Risk Stratification and Benefits With Cardiac Resynchronization Therapy (CRT)

NCT00996086
View directory record Official record
Conditions
Heart Failure, Ventricular Arrhythmias
Interventions
CRT device implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
New York, New York • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Oct 2, 2026, 5:57 AM EDT
Terminated No phase listed Observational Results available

MediGuide Registry

NCT02470312
View directory record Official record
Conditions
Heart Failure, Cardiac Arrhythmia
Interventions
CRT implantation, MediGuide, EP
Procedure · Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
578 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Phoenix, Arizona • Athens, Georgia • Lawrenceville, Georgia + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Oct 2, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Optimizing Left Ventricular Lead To Improve Cardiac Output

NCT01399801
View directory record Official record
Conditions
Ischemic Congestive Cardiomyopathy, Dilated Cardiomyopathy, Congestive Heart Failure
Interventions
Doppler flow measurement, standard implantation of the LV lead
Procedure
Lead sponsor
Ann Marie Chikowski
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Wynnewood, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 30, 2022 · Synced Oct 2, 2026, 5:57 AM EDT
Completed No phase listed Observational

Identification of the Pericardiophrenic Vein During Cardiac Device Implant Procedures to Prevent Extracardiac Stimulation

NCT01008670
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Respicardia, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
6
States / cities
Birmingham, Alabama • Baltimore, Maryland • Cincinnati, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2010 · Synced Oct 2, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Attain Performa(TM) Quadripolar Lead Study

NCT01751022
View directory record Official record
Conditions
Heart Failure
Interventions
Device: Attain Performa Pacing Lead (along with a standard CRT-D system)
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
1,202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
67
States / cities
Glendale, California • Riverside, California • San Diego, California + 64 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2016 · Synced Oct 2, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Conduction System Pacing Optimized Therapy

NCT04905290
View directory record Official record
Conditions
Heart Failure
Interventions
Left ventricular coronary sinus (BiV) configuration, Conduction system pacing-only configuration, Conduction System Pacing Optimized Therapy (CSPOT) configuration
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
7
States / cities
Tampa, Florida • Chicago, Illinois • Houma, Louisiana + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2025 · Synced Oct 2, 2026, 5:57 AM EDT