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ClinicalTrials.gov public records Last synced Nov 14, 2026, 8:06 PM EST

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Showing 1–13 of 13 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: CTO alone Clear all
Completed Not applicable Interventional

A Prospective, Multi-Center, Pivotal Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter in Facilitating Crossing Chronic Total Occlusion (CTO) Coronary Lesions

NCT02477579
View directory record Official record
Conditions
Chronic Total Occlusion of Coronary Artery
Interventions
NovaCross
Device
Lead sponsor
Nitiloop Ltd.
Industry
Eligibility
18 Years to 80 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
4
States / cities
Little Rock, Arkansas • Naperville, Illinois • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2017 · Synced Nov 14, 2026, 8:06 PM EST
Completed Not applicable Interventional Results available

The Asahi Intecc PTCA Chronic Total Occlusion Study

NCT02379923
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Artery Chronic Total Occlusion
Interventions
Crossing of Coronary Artery CTO
Device
Lead sponsor
Asahi Intecc USA Inc
Industry
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
12
States / cities
Phoenix, Arizona • Loveland, Colorado • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2018 · Synced Nov 14, 2026, 8:06 PM EST
Terminated Phase 1 Interventional

Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma

NCT01989052
View directory record Official record
Conditions
Malignant Glioma (WHO Grade III or IV)
Interventions
CTO, Lomustine
Drug
Lead sponsor
Annick Desjardins
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 4, 2016 · Synced Nov 14, 2026, 8:06 PM EST
Completed Not applicable Interventional

SoundBite™ Crossing System Pivotal Peripheral CTO Crossing Study

NCT03266835
View directory record Official record
Conditions
Chronic Total Occlusion of Arteries of the Extremities
Interventions
SoundBite™ Crossing System - Peripheral
Device
Lead sponsor
SoundBite Medical Solutions, Inc.
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Nov 14, 2026, 8:06 PM EST
Terminated Not applicable Interventional

Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.

NCT03521804
View directory record Official record
Conditions
Chronic Total Occlusion of Coronary Artery
Interventions
SoundBite™ Crossing System Active Wire 14
Device
Lead sponsor
SoundBite Medical Solutions, Inc.
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 6, 2023 · Synced Nov 14, 2026, 8:06 PM EST
Not listed Phase 1 Interventional

Safety and Tolerability of Carboxyamidotriazole Orotate (CTO) in Solid Tumors or With Temodar® in Glioblastoma or Other Recurrent Malignant Gliomas or in Combination With Temodar® and Radiation Therapy for Patients With Newly Diagnosed Glioblastoma and Malignant Gliomas

NCT01107522
View directory record Official record
Conditions
Solid Tumors, Glioblastoma, Recurrent Malignant Gliomas
Interventions
CTO, CTO and Temodar®, CTO, Temodar®, Radiation therapy
Drug
Lead sponsor
Tactical Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2026
U.S. locations
4
States / cities
New York, New York • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Nov 14, 2026, 8:06 PM EST
Completed Not applicable Interventional

Sapphire 3 CTO Study

NCT06358508
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases, Arteriosclerosis, Cardiovascular Diseases, Chronic Total Occlusion, Chronic Total Occlusion of Coronary Artery
Interventions
Sapphire 3 Coronary Dilatation Catheter
Device
Lead sponsor
OrbusNeich
Industry
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
Stanford, California • Torrance, California • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Nov 14, 2026, 8:06 PM EST
Completed No phase listed Observational Results available

Post-Market Registry of AURYON Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease

NCT04229563
View directory record Official record
Conditions
Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD
Interventions
AURYON Atherectomy System
Device
Lead sponsor
Angiodynamics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
10
States / cities
Scottsdale, Arizona • Tucson, Arizona • Davenport, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Nov 14, 2026, 8:06 PM EST
Completed Phase 1 Interventional Accepts healthy volunteers

Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions

NCT00365326
View directory record Official record
Conditions
Coronary Occlusion
Interventions
Catheter-based intracoronary injection
Biological
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2022 · Synced Nov 14, 2026, 8:06 PM EST
Terminated Phase 1 Interventional

Phase 1/2 CTO + Bevacizumab for Recurrent Glioma Post-Bevacizumab Failure

NCT01954030
View directory record Official record
Conditions
Malignant Glioma (WHO Grade III or IV)
Interventions
CTO and Bevacizumab, CTO alone
Drug
Lead sponsor
Annick Desjardins
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2016 · Synced Nov 14, 2026, 8:06 PM EST
Not listed Not applicable Interventional

Cohort B of the Pivotal Study to Evaluate the Safety and Effectiveness of the NovaCross™ Micro-catheter

NCT03719014
View directory record Official record
Conditions
Coronary Occlusion
Interventions
NovaCross
Device
Lead sponsor
Nitiloop Ltd.
Industry
Eligibility
25 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Little Rock, Arkansas • New York, New York • York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 6, 2018 · Synced Nov 14, 2026, 8:06 PM EST
Terminated No phase listed Observational Accepts healthy volunteers

REduction of Contrast Via DyeVert Used in CTO Procedures

NCT03118544
View directory record Official record
Conditions
Chronic Total Occlusion of Coronary Artery
Interventions
DyeVert System
Device
Lead sponsor
Minneapolis Heart Institute Foundation
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
3
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 17, 2018 · Synced Nov 14, 2026, 8:06 PM EST
Recruiting Not applicable Interventional

FastWire REvascularisation of Extremities, (For LOWer Limbs) - FREEFLOW

NCT06492733
View directory record Official record
Conditions
Chronic Total Occlusion of Artery of the Extremities
Interventions
FastWire System - Peripheral
Device
Lead sponsor
Versono Medical Ltd
Industry
Eligibility
18 Years to 85 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
6
States / cities
Wilmington, Delaware • Cocoa, Florida • Davenport, Iowa + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Nov 14, 2026, 8:06 PM EST