- Conditions
- Keratoconus
- Interventions
- Laser Custom Corneal Collagen Cross-Linking
- Procedure
- Lead sponsor
- Oregon Health and Science University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2027
- U.S. locations
- 1
- States / cities
- Portland, Oregon
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Showing 1–24
of 34
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Keratoconus, Corneal Diseases, Eye Diseases, Photosensitizing Agents
- Interventions
- CXLO Corneal Strengthening Solution and UVA Illumination Device
- Combination Product
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 8 Years and older
- Enrollment
- 2,228 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2020
- U.S. locations
- 9
- States / cities
- Scottsdale, Arizona • San Francisco, California • Littleton, Colorado + 6 more
- Conditions
- Down Syndrome (DS), Keratoconus, Pellucid Marginal Degeneration, Forme Fruste Keratoconus (FFK)
- Interventions
- Epi-ON corneal cross-linking (CXL)
- Combination Product
- Lead sponsor
- Woolfson Eye Institute
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 225 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2028
- U.S. locations
- 12
- States / cities
- Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more
- Conditions
- Keratoconus, Corneal Ectasia
- Interventions
- Riboflavin 0.1% ophthalmic solution, CCL-VARIO UV lamp, CCL-VARIO at 18 mW/cm2
- Drug · Device
- Lead sponsor
- Robert Mack, M.D.
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- Started 2013
- U.S. locations
- 1
- States / cities
- Hoffman Estates, Illinois
- Conditions
- Augmented Renal Clearance (ARC), Systemic Inflammatory Response Syndrome (SIRS)
- Interventions
- Ceftaroline fosamil/Avibactam (CXL)
- Drug
- Lead sponsor
- Forest Laboratories
- Industry
- Eligibility
- 18 Years to 55 Years
- Enrollment
- 12 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2013
- U.S. locations
- 19
- States / cities
- Fresno, California • Los Angeles, California • San Diego, California + 16 more
- Conditions
- Keratoconus, Corneal Ectasia
- Interventions
- Riboflavin
- Drug
- Lead sponsor
- Cornea and Laser Eye Institute
- Other
- Eligibility
- 12 Years and older
- Enrollment
- 170 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2025
- U.S. locations
- 1
- States / cities
- Teaneck, New Jersey
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Degeneration, Corneal Ectasia
- Interventions
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Combination Product
- Lead sponsor
- Cornea Associates of Texas
- Other
- Eligibility
- 8 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Keratoconus
- Interventions
- Dextenza 0.4Mg Ophthalmic Insert, topical prednisolone acetate 1% (PredForte) eye drops
- Drug
- Lead sponsor
- Maanasa Indaram, MD
- Other
- Eligibility
- 13 Years to 64 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 3
- States / cities
- San Francisco, California
- Conditions
- Corneal Ectasia Disorders Including Keratoconus
- Interventions
- CXL
- Drug
- Lead sponsor
- Rush Eye Associates
- Other
- Eligibility
- 10 Years to 70 Years
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2024
- U.S. locations
- 1
- States / cities
- Amarillo, Texas
- Conditions
- Ectasia
- Interventions
- riboflavin ophthalmic solution, UVA Irradiation
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 14 Years and older
- Enrollment
- 130 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2011
- U.S. locations
- 10
- States / cities
- La Jolla, California • San Diego, California • Miami, Florida + 7 more
- Conditions
- Fruste Keratoconus, Risk of Ectasia
- Interventions
- Corneal Cross-Linking, Riboflavin
- Device · Drug
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 22 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2014
- U.S. locations
- 8
- States / cities
- Scottsdale, Arizona • San Diego, California • Miami, Florida + 5 more
- Conditions
- Keratoconus, Ectasia, Degeneration
- Interventions
- Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Drug
- Lead sponsor
- Cxlusa
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 3,493 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2017
- U.S. locations
- 16
- States / cities
- Scottsdale, Arizona • Laguna Hills, California • San Diego, California + 13 more
- Conditions
- Pellucid Marginal Corneal Degeneration, Keratoconus, Keratectasia
- Interventions
- Brillouin Ocular Scanner
- Device
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 15 Years to 75 Years
- Enrollment
- 85 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2020
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Keratoconus, Corneal Ectasia
- Interventions
- Riboflavin
- Drug
- Lead sponsor
- Cornea and Laser Eye Institute
- Other
- Eligibility
- 21 Years and older
- Enrollment
- 160 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2025
- U.S. locations
- 1
- States / cities
- Teaneck, New Jersey
- Conditions
- Keratoconus, Keratoconus, Unstable
- Interventions
- Riboflavin 5'-Phosphate
- Drug
- Lead sponsor
- Comprehensive EyeCare of Central Ohio
- Other
- Eligibility
- 14 Years to 40 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2019
- U.S. locations
- 1
- States / cities
- Westerville, Ohio
- Conditions
- Dry Eye Disease
- Interventions
- OC-01 (varenicline 1.2mg/ml) nasal spray vs Placebo, Placebo (vehicle) nasal spray
- Drug · Other
- Lead sponsor
- Vance Thompson Vision - MT
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2022
- U.S. locations
- 1
- States / cities
- Bozeman, Montana
- Conditions
- Keratoconus
- Interventions
- The VEGA UV-A Illumination System, Riboflavin
- Device · Drug
- Lead sponsor
- Topcon Medical Systems, Inc.
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 127 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2011
- U.S. locations
- 9
- States / cities
- Phoenix, Arizona • Atlanta, Georgia • Bloomington, Minnesota + 4 more
- Conditions
- Keratitis Bacterial
- Interventions
- Moxifloxacin Ophthalmic, Difluprednate Ophthalmic, Riboflavin Ophthalmic, Topical Placebo
- Drug · Other
- Lead sponsor
- Thomas M. Lietman
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 280 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2024
- U.S. locations
- 2
- States / cities
- San Francisco, California • Miami, Florida
- Conditions
- Keratoconus and Ectasia
- Interventions
- Riboflavin, VEGA UV-A Illumination System
- Drug · Device
- Lead sponsor
- Topcon Medical Systems, Inc.
- Industry
- Eligibility
- 12 Years and older
- Enrollment
- 500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2012
- U.S. locations
- 13
- States / cities
- Phoenix, Arizona • Atlanta, Georgia • Boston, Massachusetts + 7 more
- Conditions
- Keratoconus, Ectasia
- Interventions
- Ricrolin+, Epi-Off
- Drug
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Other
- Eligibility
- 10 Years and older
- Enrollment
- 8 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2019
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Keratitis, Corneal Ulcer
- Interventions
- PXL Platinum 330 system + Riboflavin 0.25% TE Solution, Sham CXL + Artificial Tears
- Combination Product · Other
- Lead sponsor
- Peschke GmbH
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 488 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2024
- U.S. locations
- 12
- States / cities
- Littleton, Colorado • Fort Myers, Florida • Tampa, Florida + 9 more
- Conditions
- Corneal Ectasia
- Interventions
- Corneal Collagen Cross-linking
- Combination Product
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 200 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2026
- U.S. locations
- 11
- States / cities
- Palo Alto, California • Bloomington, Minnesota • Bozeman, Montana + 8 more
- Conditions
- Progressive Keratoconus
- Interventions
- riboflavin ophthalmic solution, UVA Irradiation
- Drug · Device
- Lead sponsor
- Glaukos Corporation
- Industry
- Eligibility
- 14 Years and older
- Enrollment
- 147 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2011
- U.S. locations
- 10
- States / cities
- La Jolla, California • San Diego, California • Miami, Florida + 7 more
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
- Interventions
- Not listed
- Lead sponsor
- Boston Children's Hospital
- Other
- Eligibility
- 8 Years to 35 Years
- Enrollment
- 60 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2027
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts