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ClinicalTrials.gov public records Last synced Oct 18, 2026, 2:41 PM EDT

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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Calcium Hydroxyapatite Clear all
Completed Phase 4 Interventional Results available

Injectable Filler for Cheek Flattening

NCT01225354
View directory record Official record
Conditions
Malar Deficiency
Interventions
Calcium hydroxylapatite
Drug
Lead sponsor
DeNova Research
Other
Eligibility
30 Years to 65 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Oct 18, 2026, 2:41 PM EDT
Recruiting No phase listed Observational

Spartan Stem, World Cup and World Liner Post Market Clinical Follow-up Study

NCT06172569
View directory record Official record
Conditions
Hip Replacement
Interventions
Spartan Stem, World Acetabular Cup and World Liner
Device
Lead sponsor
Signature Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 15, 2023 · Synced Oct 18, 2026, 2:41 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Novel Collagen Scaffold vs Conventional Scaffold in Regeneration of Human Dental Pulp Tissue

NCT03613090
View directory record Official record
Conditions
Root Canal Therapy
Interventions
Collagen-hydroxyapatite scaffold (Syn-Oss), Collagen Scaffold (Colla-Plug)
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Radiesse® Dermal Filler for Hand Treatment

NCT01832090
View directory record Official record
Conditions
Aging Hands
Interventions
Radiesse® Injectable Dermal Filler
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
6
States / cities
San Diego, California • Vista, California • Garden City, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Combined Focused Ultrasound and Calcium Hydroxylapatitie Filler for Skin Laxity and Volume Restoration

NCT04176068
View directory record Official record
Conditions
Skin Laxity
Interventions
calcium hydroxylapatite (Radiesse) and IFUS (Ulthera)
Combination Product
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2024 · Synced Oct 18, 2026, 2:41 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Early Caries Lesion Management Observational Study

NCT04933331
View directory record Official record
Conditions
Initial Caries, Arrested Dental Caries, Cavitated Caries, Dental Caries, Dental Caries in Children
Interventions
Curodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste
Drug · Device
Lead sponsor
CareQuest Institute for Oral Health
Other
Eligibility
4 Years and older
Enrollment
744 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
4
States / cities
Dothan, Alabama • Westborough, Massachusetts • Bend, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2023 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler

NCT01012661
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler Mixed with Lidocaine, Radiesse® Injectable Dermal Filler without Lidocaine
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Rockville, Maryland • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 26, 2013 · Synced Oct 18, 2026, 2:41 PM EDT
Recruiting Phase 4 Interventional

Restoring Facial Volume After GLP-1 Weight Loss With Radiesse

NCT07419854
View directory record Official record
Conditions
Volume Loss (Soft Tissue Ptosis or Atrophy )
Interventions
Hyperdiluted Calcium Hydroxylapatite, Calcium hydroxylapatite, Calcium hydroxylapatite with integral lidocaine
Device
Lead sponsor
Kalpna Kay Durairaj, MD, FACS
Other
Eligibility
21 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Not applicable Interventional Results available

Ridge Preservation Using a Ossix™ Bone vs Bio-Oss® Collagen

NCT04338516
View directory record Official record
Conditions
TEETH EXTRACTION
Interventions
Ossix™ Bone, Bio-Oss® Collagen
Device
Lead sponsor
Datum Dental LTD
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 18, 2026, 2:41 PM EDT
Completed No phase listed Observational

Artoss Foot and Ankle Surgery Registry

NCT04503759
View directory record Official record
Conditions
Arthritis Foot, Trauma Injury, Deformity; Bone
Interventions
NanoBone Bone Graft Substitute
Other
Lead sponsor
Artoss Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
8
States / cities
Scottsdale, Arizona • Sarasota, Florida • Joliet, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated May 13, 2024 · Synced Oct 18, 2026, 2:41 PM EDT
Enrolling by invitation Not applicable Interventional

Using Calcium Hydroxylapatite To Treat Gum Recession and Tooth Hypersensitivity

NCT06826391
View directory record Official record
Conditions
Gingival Recession, Generalized, Gingival Recession Generalized Moderate, Gingival Recession Localized Moderate, Tooth Sensitivity
Interventions
Calcium hydroxylapatite
Device
Lead sponsor
American Academy of Facial Esthetics
Network
Eligibility
20 Years to 70 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
South Euclid, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 17, 2025 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of BoneSeal® on Bone Hemostats in Patients Undergoing Cardiothoracic Surgery

NCT03085017
View directory record Official record
Conditions
Coronary Artery Bypass Grafting
Interventions
BoneSeal, Ostene
Device
Lead sponsor
Loma Linda University
Other
Eligibility
45 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Not applicable Interventional Results available

Enhanced Secondary Intention Healing vs. Standard Secondary Intention Healing in Mohs Surgical Defects on the Head and Distal Lower Extremities

NCT04545476
View directory record Official record
Conditions
Wound Heal
Interventions
Participants in this group will receive the experimental APIS Biomaterial on the Head., Participants in this group will receive the experimental APIS Biomaterial on the Lower Extremities., Standard Secondary Intention Healing on the Head, Standard Secondary Intention Healing on the Lower Extremities
Device · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 12, 2023 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Single-Center Investigator-Initiated Evaluator-Bilateral-Comparison Pilot Study of Injectable Calcium Hydroxylapatite With and Without Triamcinolone Acetate for the Treatment of Volume Loss to Dorsum Areas of the Hands

NCT02454088
View directory record Official record
Conditions
Volume Loss to Dorsum of Hands
Interventions
Calcium Hydroxylapatite and Triamcinolone acetate, Calcium Hydroxylapatite and Placebo
Other · Device
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2017 · Synced Oct 18, 2026, 2:41 PM EDT
Recruiting No phase listed Observational

TOUCH® CMC 1 New Enrollment US Study

NCT07405983
View directory record Official record
Conditions
Osteoarthritis Thumb, Thumb Carpometacarpal Joint Osteoarthritis
Interventions
TOUCH® CMC 1 Prosthesis
Device
Lead sponsor
Keri Medical SA
Industry
Eligibility
22 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
4
States / cities
Aurora, Colorado • Indianapolis, Indiana • Morrisville, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 18, 2026, 2:41 PM EDT
Not listed Not applicable Interventional

Baxter: Actifuse SHAPE vs DBX in ACC

NCT02005081
View directory record Official record
Conditions
Cervical Spine Degenerative Disease Nos, Cervical Spondylosis With Myelopathy
Interventions
Actifuse SHAPE, Autograft with Demineralized Bone Matrix
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 9, 2013 · Synced Oct 18, 2026, 2:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Alveolar Ridge Preservation Procedures

NCT05419778
View directory record Official record
Conditions
Alveolar Ridge Preservation
Interventions
Osteogen plug®, MInerOss®
Device
Lead sponsor
University of Tennessee
Other
Eligibility
12 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 8, 2022 · Synced Oct 18, 2026, 2:41 PM EDT
Withdrawn Phase 4 Interventional

Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects.

NCT01006148
View directory record Official record
Conditions
Metopic Craniosynostosis
Interventions
Allogenix Plus
Biological
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Months to 36 Months
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 30, 2016 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color

NCT01012388
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Los Angeles, California • Chevy Chase, Maryland • Ypsilanti, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2013 · Synced Oct 18, 2026, 2:41 PM EDT
Recruiting No phase listed Observational

Everglade Stem, World Cup and World Liner Post Market Clinical Follow-up

NCT06153940
View directory record Official record
Conditions
Hip Disease
Interventions
Treatment
Device
Lead sponsor
Signature Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 1, 2023 · Synced Oct 18, 2026, 2:41 PM EDT
Active, not recruiting Not applicable Interventional

OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier

NCT06447844
View directory record Official record
Conditions
Nonterminal Premolar Needing Extraction
Interventions
OsteoGen Plug, BioGide
Device
Lead sponsor
McGuire Institute
Industry
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
9
States / cities
Aurora, Colorado • Broomfield, Colorado • Boston, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 18, 2026, 2:41 PM EDT
Active, not recruiting No phase listed Observational

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

NCT05197036
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions
Total Knee Arthroplasty
Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2033
U.S. locations
12
States / cities
Atlanta, Georgia • Boston, Massachusetts • Novi, Michigan + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Not applicable Interventional Results available

This is a Post Approval Study of Coaptite® in the Treatment of Female Urinary Incontinence

NCT00996489
View directory record Official record
Conditions
Female Stress Urinary Incontinence Due to Intrinsic Sphincter Deficiency
Interventions
Coaptite®
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
459 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
20
States / cities
Wetumpka, Alabama • Surprise, Arizona • Encinitas, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Oct 18, 2026, 2:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Remineralization Effects of Hydroxyapatite Toothpaste

NCT03681340
View directory record Official record
Conditions
Caries, Dental
Interventions
Hydroxyapatite toothpaste, Fluoridated toothpaste
Other
Lead sponsor
Dr. Joachim Enax
Industry
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Oct 18, 2026, 2:41 PM EDT