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ClinicalTrials.gov public records Last synced Nov 14, 2026, 5:47 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 90 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Calorie restricted diet plus exercise Clear all

Conditions: Obesity
Interventions: Active transcranial direct current stimulation (tDCS), Hypocaloric diet, Sham transcranial direct current stimulation (tDCS); Device · Other
Lead sponsor: University of Sao Paulo; Other
Eligibility: 20 Years to 40 Years · Female only
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Diabetes
Interventions: Intermittent Fasting, Free-Living Diet, Left Arm Exercise, Right Arm Exercise; Other
Lead sponsor: University of the Pacific; Other
Eligibility: 18 Years to 65 Years
Enrollment: 46 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Stockton, California

Conditions: Breast Cancer, Primary Hormone Receptor Positive Breast Cancer
Interventions: Exercise Treatment, Plant-Based Diet, Physical activity, Nutrition counseling, Replication Exercise Test; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 7
States / cities: Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more

Conditions: Obesity, Sleep, Weight, Body, Eating Behavior, Blood Pressure, Quality of Life
Interventions: Sleep Extension; Behavioral
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 50 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
Interventions: Biospecimen Collection, Dual X-ray Absorptiometry, Functional Assessment, Lifestyle Counseling, Semaglutide; Procedure · Other · Behavioral + 1 more
Lead sponsor: Mayo Clinic; Other
Eligibility: 46 Years to 55 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2035
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Isolated Impaired Fasting Glucose
Interventions: Low-calorie diet, Routine dietary and physical activity habits; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 35 Years to 65 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Healthy Lifestyle, Obese, Men
Interventions: Diet, Exercise, Standard care; Other
Lead sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; Other
Eligibility: 18 Years to 40 Years · Male only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: Torrance, California

Conditions: Abdominal Obesity, Metabolic Syndrome
Interventions: Caloric Restriction, Caloric Restriction + Low-Intensity aerobic exercise, Caloric Restriction plus High-intensity aerobic exercise; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 50 Years to 70 Years · Female only
Enrollment: 112 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002 – 2008
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Childhood Cancer Survivors
Interventions: Children's Oncology Group Heart Health Link, Monthly weights, Fasting, Calls, Participant Questionnaires, Dried blood spot; Other
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2031
U.S. locations: 4
States / cities: New York, New York • Memphis, Tennessee • Seattle, Washington

Conditions: Weight Loss, Pediatric Obesity, Overweight Adolescents, Parent-Child Relations, Family and Household
Interventions: Brenner FIT Standard, By Design Essentials, Dyad Plus; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 13 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Prediabetes
Interventions: Low carbohydrate diet; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 100 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Colorectal Cancer, Diet Habit
Interventions: Med, WL; Other
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 45 Years to 75 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Time Restricted Eating, Diet, Mediterranean
Interventions: Time restricted eating, Mediterranean diet; Behavioral
Lead sponsor: University of California, Berkeley; Other
Eligibility: 18 Years to 65 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Overweight, Obese, Sedentary, Abdominal Obesity
Interventions: Weight Loss Diets Plus Exercise; Behavioral
Lead sponsor: Johns Hopkins University; Other
Eligibility: 30 Years to 65 Years
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Weight Loss, Cancer
Interventions: Weight Loss Only, Weight Loss Plus, Control; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years and older
Enrollment: 369 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Weight Loss
Interventions: Weight Loss Only, Weight Loss Plus; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 30 Years to 70 Years · Female only
Enrollment: 409 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2015
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Diabetes, Dementia
Interventions: Aerobic Exercise, Diet Skills; Behavioral
Lead sponsor: University of California, Davis; Other
Eligibility: 60 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Walnut Creek, California

Conditions: Obesity, Hypertension, Diabetes Mellitus, Type 2
Interventions: Overstitch Endoscopic Suture System, Lifestyle Intervention; Device · Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 21 Years to 65 Years
Enrollment: 208 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 9
States / cities: Orlando, Florida • Chicago, Illinois • Evanston, Illinois + 6 more

Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
Interventions: IDEAL2 Intervention; Behavioral
Lead sponsor: Etan Orgel; Other
Eligibility: 7 Years to 25 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2032
U.S. locations: 16
States / cities: Los Angeles, California • Orange, California • San Francisco, California + 13 more

Conditions: Breast Ductal Carcinoma In Situ, Invasive Breast Carcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7, Synchronous Bilateral Breast Carcinoma
Interventions: Health Education Program, Weight Loss Intervention; Other
Lead sponsor: Alliance for Clinical Trials in Oncology; Other
Eligibility: 18 Years and older · Female only
Enrollment: 3,177 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2030
U.S. locations: 1464
States / cities: Daphne, Alabama • Mobile, Alabama • Anchorage, Alaska + 921 more

Conditions: Non-Alcoholic Fatty Liver Disease (NAFLD)
Interventions: Milk thistle (MT), Placebo, Lifestyle Modification, Fibroscan; Drug · Behavioral · Device
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 9 Years to 22 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Obesity, Overweight, Weight Loss
Interventions: Physician Counseling, Health Educator, Phone Counseling, Health promotion materials on physical activity and nutrition; Behavioral
Lead sponsor: University of California, San Diego; Other
Eligibility: 11 Years to 13 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Obesity
Interventions: Wellness-Centered (HUGS), Weight-Centered (LEARN); Behavioral
Lead sponsor: The Reading Hospital and Medical Center; Other
Eligibility: 30 Years to 45 Years · Female only
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: West Reading, Pennsylvania

Conditions: Weight Loss, Overweight and Obesity, Behavior, Health
Interventions: Active Intervention Group, Comparison Group; Behavioral
Lead sponsor: University of Tennessee; Other
Eligibility: 16 Years and older
Enrollment: 229 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Memphis, Tennessee

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Noninvasive Neuromodulation of the Prefrontal Cortex in Subjects With Obesity

Blood Glucose Differences Between Left Arm and Right Arm Using a Continuous Glucose Monitor

A Study of the Body's Response to Exercise and a Plant-Based Diet in Overweight Postmenopausal Women With Breast Cancer

A Sleep Extension Pilot Study in Adults With Obesity

Semaglutide and Structured Lifestyle Support to Improve Heart and Blood Vessel Health in Postmenopausal Obese Breast Cancer Survivors Taking Aromatase Inhibitors

Low-calorie Diet in Isolated Impaired Fasting Glucose

Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men

Diet, Exercise, Metabolism, and Obesity in Older Women

A Study of Time-Restricted Eating in Childhood Cancer Survivors

Dyad Plus Effectiveness/Feasibility

Examining the Effects of Diet on Health in Prediabetes With an Online Program

Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer

Healthy Lifestyles for Bipolar Disorder

Evaluating the Effects Two Diets Combined With Exercise in Persons With Abdominal Obesity (The SHAPE5 Study)

Promoting Weight-Loss in African American Cancer Survivors in the Deep South

Journey to Better Health

Dementia and Diabetes Prevention Program

Multicenter Endoscopic Sleeve Gastrectomy (ESG) Trial (MERIT Trial)

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

Breast Cancer WEight Loss Study (BWEL Study)

Milk Thistle Clinical Trial in Pediatric NAFLD

PACE-PC: Primary Care Management of Adolescent Obesity

Evaluation of a Health at Every Size vs a Behavioral Weight Loss Approach for Obese Women

Choosing Healthy Activities and Lifestyle Management Through Portal Support