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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:14 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 90 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Calorie restricted diet plus exercise Clear all

Conditions: Heart Failure, Diastolic, Obesity
Interventions: dietary, aerobic and resistance training, dietary, and aerobic exercise; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 60 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Postmenopause
Interventions: conjugated estrogens, Raloxifene, exercise plus mild caloric restriction for weight loss; Drug · Behavioral
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 50 Years to 70 Years · Female only
Enrollment: 108 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2000 – 2006
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Breast Cancer
Interventions: Diabetes Prevention Program-based lifestyle change intervention (DPP), Highly Microbiota-Accessible Foods (HMAFs) intervention; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 75 Years · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Breast Cancer, Obesity, Overweight
Interventions: Calorie restricted diet plus exercise, Weight management classes; Other
Lead sponsor: USDA Grand Forks Human Nutrition Research Center; Federal
Eligibility: 44 Years to 75 Years · Female only
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Obesity
Interventions: Exercise and behavior modification; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 25 Years to 55 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Post Liver Transplantation Weight Gain, Post Liver Transplantation Obesity, Nonalcoholic Steatohepatitis
Interventions: Dietary and life style modification; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2008
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Prostate Cancer
Interventions: CLIPP; Behavioral
Lead sponsor: University of Arizona; Other
Eligibility: 40 Years to 89 Years · Male only
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Obesity
Interventions: Daily Caloric Restriction (DCR), Intermittent Fasting (IMF); Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 60 Years
Enrollment: 165 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Obesity
Interventions: Weight Loss, Exercise training, Overfeeding; Other
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 30 Years to 50 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Obesity and Overweight
Interventions: Four Month Duration Online Behavioral Weight Loss Program, Six Month Duration Online Behavioral Weight Loss Program; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 2
States / cities: Columbia, South Carolina • Burlington, Vermont

Conditions: Healthy Active Females
Interventions: Beta-hydroxy beta-methylbutyrate, Resistance Training, Protein Supplementation, Time-Restricted Feeding; Dietary Supplement · Other · Behavioral
Lead sponsor: Texas Tech University; Other
Eligibility: 18 Years to 30 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Obesity, Weight Loss, CHD - Coronary Heart Disease
Interventions: Exercise, Health Education, Exercise Compliance, Calorie-Restricted Diet, Behavioral Modification, Weight-Loss Compliance, Dietary Counseling; Other · Behavioral · Dietary Supplement
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 40 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Obesity, Morbid, Time Restricted Eating, Pregnancy Weight Gain
Interventions: Time Restricted Eating; Behavioral
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Non-Alcoholic Fatty Liver Disease
Interventions: TRE plus SOC, SOC, TRE; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2030
U.S. locations: 1
States / cities: New York, New York

Conditions: Overweight and Obesity
Interventions: Exercise Protocol, Calorie-Restrictive Low Carbohydrate Diet (CR-LC), Ancestral Diet (AD); Other
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 65 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Obesity and Obesity-related Medical Conditions
Interventions: Lifestyle Coaching; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years to 60 Years · Male only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Sommerville, Massachusetts

Conditions: Pain, Obesity, Sedentary Behavior
Interventions: MORPH; Behavioral
Lead sponsor: Wake Forest University; Other
Eligibility: 55 Years to 85 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Obesity, Older Adults, Sedentary
Interventions: Exercise Only, Exercise + Diet; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 65 Years to 80 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Pre-diabetes, Overweight and Obesity
Interventions: mHealth, Personalized mHealth; Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 269 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Obesity, Diabetes, Obstructive Sleep Apnea
Interventions: Ketogenic diet, Orlistat, Standardized diet; Other · Drug
Lead sponsor: Mid-Atlantic Epilepsy and Sleep Center, LLC; Other
Eligibility: 18 Years to 70 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Obesity, Weight Loss
Interventions: Low-Carbohydrate Diet, Low-fat Diet; Behavioral
Lead sponsor: Rutgers University; Other
Eligibility: 18 Years to 60 Years · Female only
Enrollment: 107 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Obesity, Pulmonary Disease, Dyspnea
Interventions: Not listed
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 65 Years to 85 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Prediabetes
Interventions: Blood Test Group Intervention, Brochure Group Intervention; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 315 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Obesity
Interventions: BioEnterics® Intragastric Balloon, Behavioral modification; Device · Other
Lead sponsor: Apollo Endosurgery, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 448 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Austin, Texas

Search by objective public record fields.

Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)

AFTER: Altering Fat Through Estrogen and Raloxifene

UCLA Breast Cancer Survivor Health Promotion Research Study

Weight Loss Pilot Study in Postmenopausal Breast Cancer Survivors

Nutritional Restriction and Activity Thermogenesis

Effect of Dietary and Life Style Modification on Post Liver Transplant Obesity

Comprehensive Lifestyle Improvement Program for Men With Prostate Cancer

Intermittent Fasting Versus Daily Caloric Restriction for Weight Loss

Adaptive Responses to Overfeeding and Weight

Exploring the Optimal Duration of a Group-based Online Behavioral Weight Loss Program

Time-Restricted Feeding Plus Resistance Training in Active Females

Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE)

Time-restricted Eating Among Pregnant Females With Severe Obesity

Diet and Meal Timing in Patients With Metabolic Dysfunction Associated Steatoic Liver Disease

Exercise and Nutrition on Obese Microbiome

"F!reF!ghterF!t": Lifestyle Coaching Interventions for Obese Firefighters (FireFit)

Revisiting A Mobile Intervention to Reduce Pain and Improve Health

Investigating Fitness Interventions in the Elderly (INFINITE)

A Personalized Diet Study to Reduce Glycemic Exposure

Ketogenic Diet Treatment of Obesity With Co-morbid Type 2 Diabetes Mellitus and/or Obstructive Sleep Apnea

Bitter Taste and Weight Loss in Women

EMPOWER-PULM (PULMonary Outcomes in Older Adults Empowered With Movement to Prevent Obesity and Weight Regain)

ForgIng New Paths to Prevent DIabeTes (FINDIT)

A Study of BioEnterics® Intragastric Balloon (BIB®) System to Assist in the Weight Management of Obese Subjects