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ClinicalTrials.gov public records Last synced Oct 17, 2026, 4:04 AM EDT

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Showing 49–72 of 116 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Capsaicin Clear all
Terminated Phase 3 Interventional Results available

Efficacy of Topical Capsaicin Cream for Stable Angina

NCT01231750
View directory record Official record
Conditions
Stable Angina
Interventions
Capsaicin, Placebo cream
Drug · Other
Lead sponsor
Neal Weintraub
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 25, 2015 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 1 Interventional

A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis

NCT03576508
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
CNTX-4975-05, Qutenza, Lidocaine (without epinephrine)
Drug
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
50 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Oct 17, 2026, 4:04 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health

NCT06363305
View directory record Official record
Conditions
Pre Hypertension, Hypertension
Interventions
Dietary capsules
Dietary Supplement
Lead sponsor
Skidmore College
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Saratoga Springs, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2024 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Electronic Cigarette Use on Cough Reflex Sensitivity

NCT02203162
View directory record Official record
Conditions
Cough
Interventions
electronic cigarette exposure
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 2 Interventional

ALGRX 4975 in the Treatment of Patients With Morton's Neuroma

NCT00130962
View directory record Official record
Conditions
Neuroma
Interventions
ALGRX 4975
Drug
Lead sponsor
AlgoRx Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
2
States / cities
Owings Mills, Maryland • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 3, 2005 · Synced Oct 17, 2026, 4:04 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Remote Cardiac Ischemic Preconditioning

NCT06390358
View directory record Official record
Conditions
Cardiac Function and Preconditioning
Interventions
Tefillin
Other
Lead sponsor
Jack Rubinstein
Other
Eligibility
18 Years and older · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Oct 17, 2026, 4:04 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Effect of Spinal Ketorolac After Acute Opioid Exposure

NCT00693160
View directory record Official record
Conditions
Healthy
Interventions
ketorolac, placebo, remifentanil, Capsaicin
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 7, 2018 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 2 Interventional

Capsaicin to Control Pain Following Third Molar Extraction

NCT00088686
View directory record Official record
Conditions
Healthy, Tooth Extraction
Interventions
Capsaicin (Intramucosal Injection)
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Neurobiology of Expectancy and Pain Perception

NCT01575106
View directory record Official record
Conditions
Pain
Interventions
Heat pain applied using TSA or CHEPS
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years to 50 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults

NCT01854268
View directory record Official record
Conditions
Cough
Interventions
Healthy adults who receive capsaicin
Drug
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2022 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 4 Interventional

Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome

NCT04283292
View directory record Official record
Conditions
Cannabinoid Hyperemesis Syndrome
Interventions
Capsaicin, Placebo
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 18, 2024 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy

NCT05098067
View directory record Official record
Conditions
Hyperemesis Gravidarum, Nausea Gravidarum, Vomiting of Pregnancy
Interventions
Capsaicin Topical Cream, Metoclopramide, Ondansetron, Lactated Ringers, Intravenous
Drug
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 7, 2024 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Remote Ischemic Preconditioning Mechanism Study

NCT01541436
View directory record Official record
Conditions
Pain
Interventions
Remote Ischemic Preconditioning, Capsaicin, UV-B
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 10, 2018 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 3 Interventional

Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia

NCT00068081
View directory record Official record
Conditions
Herpes Zoster, Neuralgia, Pain, Peripheral Nervous System Diseases
Interventions
Capsaicin Dermal Patch
Drug
Lead sponsor
NeurogesX
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
19
States / cities
Mesa, Arizona • Peoria, Arizona • Phoenix, Arizona + 15 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2008 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects

NCT00655811
View directory record Official record
Conditions
Healthy
Interventions
Capsaicin, Placebo moisturizing cream
Drug
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 50 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 10, 2018 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain

NCT02441660
View directory record Official record
Conditions
Spinal Cord Injuries, Neuropathic Pain
Interventions
Capsaicin 8% Patch, Low Dose Capsaicin 0.025% Well Patch
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 99 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2023 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 3 Interventional Results available

The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population

NCT05093478
View directory record Official record
Conditions
Non-allergic Rhinitis
Interventions
Intranasal capsaicin, topical lidocaine
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Early Phase 1 Interventional Results available

Cough Desensitization Therapy for Cough Hypersensitivity Syndrome

NCT04256733
View directory record Official record
Conditions
Cough
Interventions
Supra-threshold and progressive doses of diluted capsaicin via a Koko Digidoser nebulizer, Sub-threshold doses of diluted capsiacin via a KoKo Digidoser nebulizer
Biological
Lead sponsor
University of Montana
Other
Eligibility
18 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Oct 17, 2026, 4:04 AM EDT
Completed No phase listed Observational Results available

Airway Protective Mechanisms in PD (R01)

NCT03321019
View directory record Official record
Conditions
Parkinson Disease
Interventions
Capsaicin, Resistive respiratory loads, Event-related evoked potential using electroencephalography (EEG)., Fluoroscopic swallow evaluation
Drug · Device · Other + 1 more
Lead sponsor
University of Florida
Other
Eligibility
45 Years to 85 Years
Enrollment
119 participants
Timeline
2017 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 10, 2024 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 3 Interventional

Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy

NCT00064623
View directory record Official record
Conditions
HIV Infections, Peripheral Nervous System Diseases, Pain
Interventions
Capsaicin Dermal Patch
Drug
Lead sponsor
NeurogesX
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
35
States / cities
Phoenix, Arizona • Berkeley, California • San Diego, California + 29 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2008 · Synced Oct 17, 2026, 4:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stimulation of Sensation and Improvement in Swallowing Using Oral Capsaicin

NCT01053286
View directory record Official record
Conditions
Dysphagia, Gastroesophageal Reflux
Interventions
Not listed
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 2Phase 3 Interventional

NGX-4010 for the Treatment of Postherpetic Neuralgia

NCT00061776
View directory record Official record
Conditions
Herpes Zoster, Neuralgia, Pain, Peripheral Nervous System Diseases, Shingles
Interventions
Capsaicin Dermal Patch
Drug
Lead sponsor
NeurogesX
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
28
States / cities
Huntsville, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 25 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2008 · Synced Oct 17, 2026, 4:04 AM EDT
Completed Phase 1 Interventional

Sickle Cell Pain: Intervention With Capsaicin Exposure

NCT03899246
View directory record Official record
Conditions
Neuropathic Pain, Sickle Cell Disease
Interventions
Eight Percent Topical Capsaicin
Drug
Lead sponsor
Children's Hospital of Michigan
Other
Eligibility
14 Years to 21 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 17, 2026, 4:04 AM EDT
Not yet recruiting Phase 4 Interventional

High-concentration Capsaicin Patch for the Prevention of Paclitaxel-induced Peripheral Neuropathy

NCT07834281
View directory record Official record
Conditions
Chemotherapy-induced Peripheral Neuropathy, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Interventions
High Concentration Capsaicin Patch (HCCP), Placebo patch
Other
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 17, 2026, 4:04 AM EDT