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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cardiac resynchronization pacing Clear all
Recruiting Not applicable Interventional

Left vs Left Randomized Clinical Trial

NCT05650658
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, AV Block, LBBB, RBBB, Intraventricular Conduction Delay, Pacing-Induced Cardiomyopathy
Interventions
His/LBBP, BiVP
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
2,136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
57
States / cities
Gilbert, Arizona • Tucson, Arizona • Little Rock, Arkansas + 46 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 10, 2026, 3:09 AM EDT
Completed Not applicable Interventional

Attain StarFix™ Model 4195 Left Ventricular Lead

NCT00269230
View directory record Official record
Conditions
Heart Failure
Interventions
Pacing Lead
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
441 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
20
States / cities
Long Beach, California • Palo Alto, California • Newark, Delaware + 17 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2008 · Synced Sep 10, 2026, 3:09 AM EDT
Completed No phase listed Observational Results available

QuickFlex Micro Left Ventricular Lead Post Approval Study

NCT01179477
View directory record Official record
Conditions
Heart Failure
Interventions
Implantation of a QuickFlex® μ Model 1258T LV Lead
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
1,930 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
77
States / cities
Birmingham, Alabama • Huntsville, Alabama • Anchorage, Alaska + 67 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2019 · Synced Sep 10, 2026, 3:09 AM EDT
Completed Not applicable Interventional

InSync III Marquis Model 7279 Cardioverter Defibrillator Cardiac Resynchronization System

NCT00271232
View directory record Official record
Conditions
Heart Failure
Interventions
Cardiac resynchronization therapy
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
34
States / cities
Anchorage, Alaska • Phoenix, Arizona • Los Angeles, California + 31 more
Source: ClinicalTrials.gov public record
Updated Dec 20, 2007 · Synced Sep 10, 2026, 3:09 AM EDT
Recruiting Not applicable Interventional

His-Bundle Corrective Pacing in Heart Failure

NCT05265520
View directory record Official record
Conditions
Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
Interventions
His-CRT implantation, BIV-CRT implantation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
14
States / cities
Phoenix, Arizona • Los Angeles, California • Tampa, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 10, 2026, 3:09 AM EDT
Completed Phase 4 Interventional Results available

Response of Cardiac Resynchronization Therapy Optimization With Ventricle to Ventricle Timing in Heart Failure Patients

NCT00187200
View directory record Official record
Conditions
Heart Failure
Interventions
Simultaneous VV Pacing, Sequential VV Pacing
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
816 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Sep 10, 2026, 3:09 AM EDT
Completed Not applicable Interventional Results available

Cardiac Resynchronization Therapy Efficacy Enhancements

NCT02222818
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Conducted AF Response (CAFR), Conducted AF Response Plus (CAFRPlus)
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
10
States / cities
Boca Raton, Florida • West Des Moines, Iowa • Minneapolis, Minnesota + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 5, 2017 · Synced Sep 10, 2026, 3:09 AM EDT
Completed No phase listed Observational

iBeat Wristwatch Validation Study

NCT03711695
View directory record Official record
Conditions
Arrythmia, Cardiac
Interventions
iBeat wristwatch device
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 85 Years
Enrollment
55 participants
Timeline
2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2019 · Synced Sep 10, 2026, 3:09 AM EDT
Withdrawn Not applicable Interventional

Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response

NCT05884411
View directory record Official record
Conditions
Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction, CRT Non-Response, Left Bundle Branch Area Pacing
Interventions
Left bundle branch area pacing, Cardiac MRI
Device · Diagnostic Test
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Sep 10, 2026, 3:09 AM EDT
Completed No phase listed Observational

Predicting Response to Cardiac Resynchronization Therapy in Heart Failure

NCT00359372
View directory record Official record
Conditions
Heart Failure, Left Ventricular Dysfunction
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
3
States / cities
Baltimore, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated Not applicable Interventional Results available

Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)

NCT01169493
View directory record Official record
Conditions
Heart Failure, Right Bundle-Branch Block
Interventions
VVI-40, RV DDD-40, BiV DDD-40
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 22, 2016 · Synced Sep 10, 2026, 3:09 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Cardiac Resynchronization Therapy in Previously Untreatable and High Risk Upgrade Patients

NCT02922036
View directory record Official record
Conditions
Heart Failure
Interventions
WiSE System
Device
Lead sponsor
EBR Systems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
43
States / cities
Huntsville, Alabama • La Jolla, California • Fort Lauderdale, Florida + 37 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2025 · Synced Sep 10, 2026, 3:09 AM EDT
Completed No phase listed Observational

InSync Implantable Cardioverter Defibrillator Registry: Cardiac Resynchronization Therapy

NCT00289302
View directory record Official record
Conditions
Heart Failure, Cardiomyopathy
Interventions
Cardiac resynchronization therapy device
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
51
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 48 more
Source: ClinicalTrials.gov public record
Updated Oct 4, 2007 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated Not applicable Interventional Results available

Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure (The SPARK Trial)

NCT02441101
View directory record Official record
Conditions
Right Bundle-Branch Block, Heart Failure
Interventions
RV DDD(R)-60 with AV optimization, RV DDD(R)-60
Device
Lead sponsor
Barry London
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated Not applicable Interventional Results available

Survey of QRS Frequency at Various Left Ventricular Pacing Sites for Cardiac Resynchronization

NCT03253809
View directory record Official record
Conditions
Cardiomyopathies, Congestive Heart Failure
Interventions
Biotronik Vision Guidewire
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 8, 2022 · Synced Sep 10, 2026, 3:09 AM EDT
Completed Not applicable Interventional

Comparison of Epicardial Versus Conventional Lead Placement in Cardiac Resynchronization Therapy

NCT01302470
View directory record Official record
Conditions
Cardiac Resynchronization Therapy, Heart Failure
Interventions
Primary epicardial placement of left ventricular lead, Transvenous placement of left ventricular lead
Procedure
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 18, 2015 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated Not applicable Interventional

Adaptive Cardiac Resynchronization Therapy in Patients With RBBB

NCT05936294
View directory record Official record
Conditions
Right Bundle-Branch Block
Interventions
Optimization of CRT Device
Diagnostic Test
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
2
States / cities
Little Rock, Arkansas • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 6, 2023 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Optimized Biventricular Pacing Allograft Recipients

NCT01290822
View directory record Official record
Conditions
Dilated Cardiomyopathy, Ischemic Cardiomyopathy
Interventions
BiVP, AAI Pacing
Device
Lead sponsor
Henry M. Spotnitz
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2016 · Synced Sep 10, 2026, 3:09 AM EDT
Completed Not applicable Interventional Results available

REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)

NCT00271154
View directory record Official record
Conditions
Heart Failure
Interventions
Cardiac Resynchronization Therapy (CRT) Device or Implantable Cardioverter Defibrillator (ICD) with CRT
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
684 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
34
States / cities
Huntsville, Alabama • Anchorage, Alaska • Redwood City, California + 31 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2012 · Synced Sep 10, 2026, 3:09 AM EDT
Not listed Not applicable Interventional

Optimal Pacing Rate for Cardiac Resynchronization Therapy

NCT06445439
View directory record Official record
Conditions
Atrial Fibrillation, Persistent
Interventions
Pacing rate of 80 bpm, Pacing rate of 60 bpm
Device
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
5
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland • Clinton, Maryland + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated No phase listed Observational Results available

OMNI Study--Assessing Therapies in Medtronic Pacemaker, Defibrillator, and Cardiac Resynchronization Therapy Devices.

NCT00277524
View directory record Official record
Conditions
Tachycardia, Ventricular, Heart Failure, Congestive, Ventricular Fibrillation, Ventricular Dysfunction, Bradycardia
Interventions
Not listed
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
3,032 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
113
States / cities
Tucson, Arizona • Little Rock, Arkansas • Fresno, California + 107 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2013 · Synced Sep 10, 2026, 3:09 AM EDT
Completed Not applicable Interventional Results available

Evaluation of ACUITY™ X4 Quadripolar Coronary Venous Leads and RELIANCE™ 4-FRONT Defibrillation Leads

NCT02071173
View directory record Official record
Conditions
Cardiac Resynchronization Therapy
Interventions
ACUITY X4 quadripolar coronary venous lead and RELIANCE 4-FRONT defibrillation lead
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
2,244 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
96
States / cities
Birmingham, Alabama • Huntsville, Alabama • Anchorage, Alaska + 85 more
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Echocardiography Guided Cardiac Resynchronization Therapy (EchoCRT)

NCT00683696
View directory record Official record
Conditions
Heart Failure, Ventricular Dyssynchrony
Interventions
Implantable Cardioverter Defibrillator with Cardiac Resynchronization Therapy (BIOTRONIK Lumax HF-T CRT-D)
Device
Lead sponsor
Biotronik, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,680 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
62
States / cities
Concord, California • Los Angeles, California • Rancho Mirage, California + 46 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2018 · Synced Sep 10, 2026, 3:09 AM EDT
Terminated Not applicable Interventional

Effect of Cardiac Resynchronization Therapy (CRT) on Left Ventricular Assist Device (LVAD) Function

NCT04153786
View directory record Official record
Conditions
LVAD (Left Ventricular Assist Device) Driveline Infection
Interventions
Temporary changes in an already-implanted medical device (biventricular pacemaker)
Other
Lead sponsor
University of California, Davis
Other
Eligibility
Not listed
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 6, 2024 · Synced Sep 10, 2026, 3:09 AM EDT