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Showing 1–24 of 35 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Stickler Syndrome Type 1, Stickler Syndrome Type 2
Interventions
Prophylactic (non-invasive) Laser Retinopexy
Procedure
Lead sponsor
Helen Keller Eye Research Foundation
Other
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
5
States / cities
Birmingham, Alabama • Royal Oak, Michigan • Minneapolis, Minnesota + 2 more
Terminated Not applicable Interventional

Cerclage for Short Cervix in Twins

NCT02912390
Conditions
Short Cervix, Twins
Interventions
Cerclage, Expectant management
Procedure · Other
Lead sponsor
St. Louis University
Other
Eligibility
14 Years to 45 Years · Female only
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
St Louis, Missouri
Conditions
Sternotomy
Interventions
Stainless Steel Wire Cerclage
Device
Lead sponsor
Arthrex, Inc.
Industry
Eligibility
18 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Fort Myers, Florida
Completed Not applicable Interventional Accepts healthy volunteers Results available

Endoscopic Surgery for Bariatric Revision After Weight Loss Failure

NCT01871896
Conditions
Morbid Obesity, Weight Loss
Interventions
Endoscopic Suturing to Create Early Satiety
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2022
U.S. locations
1
States / cities
San Francisco, California
Recruiting Not applicable Interventional

Sternal Plating High Risk

NCT06660186
Conditions
Heart Diseases
Interventions
Rigid Sternal Fixation, Wire Cerclage
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Not listed Not applicable Interventional Accepts healthy volunteers

Single Versus Double Suture Cervical Cerclage to Prevent Preterm Birth

NCT04742647
Conditions
The Primary Outcome is Preterm Delivery Before 28 Weeks Gestational Age Compared to Women With One vs Two Cerclages Placed
Interventions
Double cerclage, Single cerclage
Procedure
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older · Female only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Stony Brook, New York
Conditions
Labor, Premature
Interventions
cervical cerclage
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
16 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Birmingham, Alabama
Conditions
Twin Pregnancy With Antenatal Problem, Preterm Birth, Short Cervix
Interventions
Cervical cerclage
Procedure
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Philadelphia, Pennsylvania • Austin, Texas
Conditions
Mid Trimester Cervical Shortening
Interventions
McDonald cerclage placement, 17 hydroxyprogesterone caproate
Procedure · Drug
Lead sponsor
Lehigh Valley Hospital
Other
Eligibility
Female only
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Allentown, Pennsylvania
Not listed No phase listed Observational Accepts healthy volunteers

fFN Clinical Evaluation in Asymptomatic Women at High Risk for Preterm Birth

NCT01955148
Conditions
Pre-term Birth
Interventions
Not listed
Lead sponsor
Hologic, Inc.
Industry
Eligibility
18 Years to 65 Years · Female only
Enrollment
1,210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
16
States / cities
Birmingham, Alabama • San Diego, California • Newark, Delaware + 13 more
Conditions
Functional Mitral Regurgitation
Interventions
Transmural Systems Transcatheter Mitral Cerclage Annuloplasty (TMCA)
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Atlanta, Georgia • Roanoke, Virginia
Completed No phase listed Observational Accepts healthy volunteers

Cervical Stiffness Measurement in Cervical Insufficiency

NCT04158401
Conditions
Pregnancy Related, Cervical Insufficiency, Preterm Birth
Interventions
Pregnolia
Device
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Preterm Birth, Obstetric Labor, Premature, Obstetric Labor Complications, Pregnancy Complications, Physiological Effects of Drugs, Uterine Cervical Incompetence, Anti-Bacterial Agents, Azithromycin, Cefazolin
Interventions
Azithromycin 1 gram IV, Cefazolin and indomethacin
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • New Brunswick, New Jersey
Conditions
Preterm Birth
Interventions
Physical Exam Indicated Cerclage
Procedure
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Albany, New York
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs

NCT04301518
Conditions
Preterm Labor, Preterm Birth
Interventions
Multimodal intervention strategy
Other
Lead sponsor
Sera Prognostics, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
6,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
18
States / cities
San Diego, California • New Haven, Connecticut • Newark, Delaware + 15 more
Conditions
Functional Mitral Regurgitation, Heart Failure
Interventions
Mitral Loop Cerclage Annuloplasty
Device
Lead sponsor
Tau-MEDICAL Co., Ltd.
Industry
Eligibility
20 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Retrospective Review, Cerclage, Pain Management
Interventions
Montage or Montage CT
Device
Lead sponsor
Abyrx, Inc.
Industry
Eligibility
19 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Naples, Florida • St Louis, Missouri
Completed No phase listed Observational Accepts healthy volunteers

The Impact of Vaginal and IM Progestins on the Cervix

NCT01954095
Conditions
Preterm Birth, Short Cervical Length
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
4
States / cities
Indianapolis, Indiana • Pittsburgh, Pennsylvania • Galveston, Texas + 1 more
Not yet recruiting Phase 4 Interventional

Azithromycin for Cerclage Prophylaxis

NCT07608562
Conditions
Cervical Insufficiency
Interventions
Azithromycin Prophylaxis, Azithromycin Placebo, Cefazolin, Progesterone
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Oak Lawn, Illinois • Park Ridge, Illinois
Conditions
Fetal Membranes, Premature Rupture
Interventions
Retention of Cerclage, Removal of Cerclage, Removal vs. Retention of Cervical Cerclage
Procedure
Lead sponsor
Obstetrix Medical Group
Industry
Eligibility
18 Years to 60 Years · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2014
U.S. locations
23
States / cities
Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 18 more
Conditions
Premature Birth
Interventions
Arabin Pessary
Device
Lead sponsor
Gene Lee, MD
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
Kansas City, Kansas • Charleston, South Carolina
Conditions
Cervical Incompetence
Interventions
Chloroprocaine, Bupivacaine
Drug
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Terminated Not applicable Interventional Accepts healthy volunteers

Ibuprofen Versus Indomethacin Following Emergent Cerclage Placement

NCT04726085
Conditions
Preterm Labor
Interventions
Indomethacin 150mg, Ibuprofen 2400mg
Drug
Lead sponsor
Woman's
Other
Eligibility
18 Years and older · Female only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Recruiting Not applicable Interventional Accepts healthy volunteers

LATe Cerclage in High-risk Pregnancies (LATCH)

NCT06036446
Conditions
Premature Birth
Interventions
Cervical cerclage, Vaginal Suppository Progesterone
Procedure · Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
329 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
2
States / cities
Charlotte, North Carolina • Philadelphia, Pennsylvania