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Showing 1–24 of 75 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cervical Spine Manipulation Clear all
Not listed Not applicable Interventional

Osteopathic Manipulation in Breastfed Newborns

NCT03945474
View directory record Official record
Conditions
Osteopathic Medicine, Breast Feeding
Interventions
Sham, Osteopathic Manipulation, OMT
Other
Lead sponsor
Methodist Medical Center of Illinois
Other
Eligibility
20 Hours to 2 Weeks
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
2
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated May 9, 2019 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Spinal Manipulation and Dry Needling Versus Conventional Physical Therapy in Patients With Cervicogenic Headache

NCT02373605
View directory record Official record
Conditions
Cervicogenic Headaches
Interventions
Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
18 Years to 65 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Montgomery, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Sep 1, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional

Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

NCT06906107
View directory record Official record
Conditions
Neck Pain Musculoskeletal, Neck Pain Treatment, Cervicalgia
Interventions
Cervical Manipulation, Exercise, Mobilization
Procedure
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 70 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Rochester, Minnesota • Syracuse, New York • Waco, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 1, 2026, 7:48 PM EDT
Not listed Not applicable Interventional

Effects of Osteopathic Manipulative Treatment (OMT) on Gait Biomechanics in Parkinson's Disease

NCT03616145
View directory record Official record
Conditions
Parkinson Disease
Interventions
Osteopathic Manipulative Treatment (OMT), Light Touch
Procedure · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2023 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Integrating Chiropractic Care and Mind-Body Training for the Treatment of Nonspecific Chronic Neck Pain

NCT06523036
View directory record Official record
Conditions
Neck Pain, Nurse-Patient Relations
Interventions
Combined chiropractic care and Tai Chi
Procedure
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Using fMRI to Determine if Cerebral Hemodynamic Responses to Pain Change Following Thoracic Spine Manipulation in Individuals With Mechanical Neck Pain

NCT01862705
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spine manipulation
Other
Lead sponsor
OSF Healthcare System
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Sep 1, 2026, 7:48 PM EDT
Not listed Not applicable Interventional

Cardiovascular Response to Two Manual Techniques for Neck Pain

NCT02198677
View directory record Official record
Conditions
Neck Pain
Interventions
Anterior to posterior pressures, Lateral glide
Procedure
Lead sponsor
Azusa Pacific University
Other
Eligibility
18 Years to 50 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Azusa, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2016 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Objective Kinematic Correlates of Palpatory Diagnosis

NCT00728247
View directory record Official record
Conditions
Cervical Spine
Interventions
Manual Therapy Techniques
Procedure
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 19, 2010 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain

NCT02245425
View directory record Official record
Conditions
Neck Pain
Interventions
Supine Thoracic Spine Manipulation, Prone Thoracic Spine Manipulation
Other
Lead sponsor
A.T. Still University of Health Sciences
Other
Eligibility
22 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 8, 2018 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sacroiliac Orthopedic Blocking and Cervical Spine Function

NCT00523822
View directory record Official record
Conditions
Musculoskeletal Diseases
Interventions
Spinal Manipulative Therapy
Other
Lead sponsor
Logan College of Chiropractic
Other
Eligibility
20 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Chesterfield, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 4, 2008 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Short-Term Response of Thoracic Spine Manipulation With or Without Trigger Point Dry Needling for Mechanical Neck Pain

NCT02415660
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic spinal manipulation, Trigger point dry needling, Cervical range of motion exercises, Posterior neck muscle activation exercise, Trigger point dry needling sham, Seirin J-type stainless steel needles, 0-2-0.3 x 40-50 mm
Procedure · Behavioral · Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2021 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Cervical Spine Manipulation on Gait

NCT02287324
View directory record Official record
Conditions
Cervicalgia
Interventions
Manipulation, Manual Contact
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Nov 9, 2014 · Synced Sep 1, 2026, 7:48 PM EDT
Recruiting Not applicable Interventional

Normalizing Cervical Intersegmental Kinematics With Spinal Manipulative Therapy

NCT06312696
View directory record Official record
Conditions
Neck Pain
Interventions
SMT, Light Massage
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 39 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 1, 2026, 7:48 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Treatment and Migraine Headaches

NCT04976985
View directory record Official record
Conditions
Chronic Migraine, Migraine Disorders, Headache Disorders, Headache, Migraine
Interventions
Osteopathic Manipulative Therapy (OMT), Standard of care
Procedure · Other
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years to 50 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Sep 1, 2026, 7:48 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Osteopathic Manipulative Medicine and Kinetics

NCT01376687
View directory record Official record
Conditions
Cervical Spine
Interventions
Not listed
Lead sponsor
Michigan State University
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 30, 2011 · Synced Sep 1, 2026, 7:48 PM EDT
Suspended Not applicable Interventional

A Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain

NCT02972710
View directory record Official record
Conditions
Neck Pain
Interventions
Supine thoracic spine thrust manipulation, Seated thoracic spine thrust manipulation
Other
Lead sponsor
Northern Arizona University
Other
Eligibility
20 Years to 50 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Flagstaff, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional Results available

Manual Cervical Distraction: Measuring Chiropractic Delivery for Neck Pain Clinical Trial

NCT01765751
View directory record Official record
Conditions
Neck Pain, Pain in Arm, Unspecified
Interventions
Manual Cervical Distraction
Procedure
Lead sponsor
Palmer College of Chiropractic
Other
Eligibility
18 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 3, 2018 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Comparison of Two Thoracic Manipulation Techniques to Improve Neck Pain in Dentistry Students

NCT01962090
View directory record Official record
Conditions
Neck Pain
Interventions
Thoracic Spine Thrust in Seated Position, Thoracic Spine Thrust in Supine Position
Other
Lead sponsor
A.T. Still University of Health Sciences
Other
Eligibility
22 Years to 45 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Mesa, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Patient Perceptions Following a Single Session of Simulated or Genuine HVLA Manual Chiropractic Adjustments

NCT06153290
View directory record Official record
Conditions
Subluxation
Interventions
Chiropractic adjustment, Sham adjustment
Procedure
Lead sponsor
Life University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Sep 1, 2026, 7:48 PM EDT
Terminated Phase 1 Interventional

Pilot Study of Spinal Manipulation for Chronic Neck Pain

NCT00030004
View directory record Official record
Conditions
Neck Pain
Interventions
spinal manipulation, midazolam
Procedure · Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2001
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 17, 2006 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Mobilization Versus Manipulation for the Treatment of Cervicogenic Headaches

NCT03919630
View directory record Official record
Conditions
Cervicogenic Headache
Interventions
Thrust Mobilization, Non-Thrust Mobilizations
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Havertown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of OMT on Gait Kinematics and Postural Control in Parkinson Disease

NCT04946760
View directory record Official record
Conditions
Parkinson Disease
Interventions
Sham Manipulation
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
50 Years and older
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cervical Spine Manipulation Affects on Balance and Proprioception

NCT01745705
View directory record Official record
Conditions
Neck Pain, Headache
Interventions
Cervical Spine Manipulation, Manual Contact
Other
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Sep 1, 2026, 7:48 PM EDT
Completed Not applicable Interventional

Effects of Cervical Manipulation on Cervical Rotation Motion and Shoulder Rotational Motion and Strength in Overhead Athletes

NCT06903793
View directory record Official record
Conditions
Cervical Spine, Manipulation, Spinal, Shoulder, Overhead Athlete
Interventions
cervical manipulation
Other
Lead sponsor
Sacred Heart University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Fairfield, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Sep 1, 2026, 7:48 PM EDT