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ClinicalTrials.gov public records Last synced Oct 25, 2026, 10:08 AM EDT

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Showing 601–624 of 1,539 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Challenge Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate the Potential of Tazarotene Foam to Cause an Allergic Reaction When Applied to the Skin and Exposed to Light on Healthy Volunteers.

NCT01119651
View directory record Official record
Conditions
Acne Vulgaris
Interventions
Tazarotene (Patch application in Challenge Phase)
Drug
Lead sponsor
Stiefel, a GSK Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Emotion-Diet Interactions in Pregnancy

NCT04430439
View directory record Official record
Conditions
Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy, Emotional Stress, Postprandial Hyperglycemia, Insulin Sensitivity/Resistance
Interventions
Psychosocial stress, Control non-stress
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
Irvine, California • Orange, California
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Dermal Irritation, Sensitization and Cumulative Irritation Potential of 6% Bemotrizinol

NCT05260359
View directory record Official record
Conditions
Sunburn
Interventions
6% Bemotrizinol (BEMT) in a basic sunscreen oil formulation, 6% Bemotrizinol (BEMT) dispersion in petrolatum, Sunscreen oil vehicle with 10% ethanol as penetration enhancer without BEMT, Petrolatum vehicle, 0.9% Saline, Sodium Lauryl Sulfate 0.1% (SLS), Undosed patch
Drug · Other
Lead sponsor
dsm-firmenich Switzerland AG
Industry
Eligibility
18 Years to 75 Years
Enrollment
224 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional Results available

Comprehensive Post-Acute Stroke Services

NCT02588664
View directory record Official record
Conditions
Stroke, Transient Ischemic Attack
Interventions
COMPASS Intervention
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
6,024 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
40
States / cities
Albemarle, North Carolina • Asheville, North Carolina • Chapel Hill, North Carolina + 32 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2021 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional Results available

Continuous Glucose Monitoring for Screening for Diabetes in Pregnancy

NCT05430204
View directory record Official record
Conditions
Gestational Diabetes
Interventions
Group 1: one-hour GCT, Group 2: CGM placement
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
1,628 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Oct 25, 2026, 10:08 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Study to Evaluate the Safety, Pharmacokinetic, and Pharmacodynamic Effects of MY006 in Healthy Volunteers and Patients With Peanut Allergy

NCT07287033
View directory record Official record
Conditions
Peanut Allergies
Interventions
MY006 Low Dose, MY006 Mid Dose, MY006 High Dose, MY006 Selected Dose, Placebo (Vehicle)
Drug
Lead sponsor
Mabylon AG
Industry
Eligibility
12 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
9
States / cities
Little Rock, Arkansas • Aurora, Colorado • Colorado Springs, Colorado + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Phase I Norovirus Challenge Model

NCT04174560
View directory record Official record
Conditions
Gastroenteritis Norovirus
Interventions
Norovirus GII.4 Challenge Pool
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 49 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Oct 25, 2026, 10:08 AM EDT
Withdrawn Phase 4 Interventional

Post-Operative Pain Control in Opioid Tolerant Patients: Fentanyl Challenge Protocol Versus Standard of Care

NCT02324933
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Fentanyl
Drug
Lead sponsor
Bassett Healthcare
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Cooperstown, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2015 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional Results available

Use of Construal Level Theory to Inform Messaging to Increase Vaccination Against COVID-19

NCT04871776
View directory record Official record
Conditions
Covid19, Vaccine Refusal
Interventions
Messaging informed by construal level theory, Usual Care
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
3,671 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 16, 2024 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.

NCT03389750
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Intravenous Challenge Drug
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
Lexington, Kentucky • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Oct 25, 2026, 10:08 AM EDT
Recruiting Not applicable Interventional

Resilience in Reentry: Cognitive-Behavioral Resilience Training for Parolees With Adjustment Challenges

NCT07167719
View directory record Official record
Conditions
Adjustment
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 25, 2026, 10:08 AM EDT
Not yet recruiting Not applicable Interventional

Feasibility of Addressing Sexual Dysfunction in Women with Breast and Gynecologic Cancers with a Novel Mobile Application

NCT06694142
View directory record Official record
Conditions
Sexual Dysfunction
Interventions
Rosy app
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Frontal Cortex and Gait Freezing in Parkinson's Disease: Rehabilitation Impact

NCT02236286
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Exercise
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
50 Years to 90 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional

Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury

NCT03307070
View directory record Official record
Conditions
Major Depressive Disorder, Traumatic Brain Injury
Interventions
Cognitive Behavioral Therapy for individuals with TBI, Waitlist Control
Behavioral · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 10, 2023 · Synced Oct 25, 2026, 10:08 AM EDT
Recruiting Not applicable Interventional

Infant Formula in Infants and Children With Cow's Milk Allergy

NCT06456541
View directory record Official record
Conditions
Cow's Milk Allergy
Interventions
Experimental Extensively Hydrolyzed Formula, Placebo Extensively Hydrolyzed Formula
Other
Lead sponsor
Abbott Nutrition
Industry
Eligibility
3 Months to 12 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
9
States / cities
Phoenix, Arizona • Aurora, Colorado • Chicago, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 25, 2026, 10:08 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cannabis Tolerance Break Resource Study: T-Break Guide

NCT05382273
View directory record Official record
Conditions
Cannabis Use, Tolerance, Cannabis Withdrawal
Interventions
T-Break Guide
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 19, 2022 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional

DOD Regulating Together Intervention

NCT05803369
View directory record Official record
Conditions
Autism Spectrum Disorder, Emotion Regulation
Interventions
Regulating Together (RT), Achieving Independence and Mastery in School (AIMS)
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years to 12 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional

Early Intervention Foster Care: A Prevention Trial

NCT00701194
View directory record Official record
Conditions
School Readiness, Developmental Delays
Interventions
Early Intervention Foster Care (EIFC)
Behavioral
Lead sponsor
Oregon Social Learning Center
Other
Eligibility
3 Years to 6 Years
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2011
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Phase 1 Interventional

Influenza A H3N2 Human Challenge Study in Healthy Adult Volunteers

NCT02594189
View directory record Official record
Conditions
Determine Minimally to Moderately Infective Dose (MMID) of Influenza A H3N2
Interventions
Live recombinantly derived A/Bethesda/MM1/H3N2 virus
Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Can Mental Health Apps Work in the Real World? A Feasibility Pilot Study.

NCT01808976
View directory record Official record
Conditions
MDD
Interventions
Problem Solving Therapy, Evolution, Basic health push app
Other · Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 4, 2017 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Norovirus Challenge Study

NCT05212168
View directory record Official record
Conditions
Norovirus Infections
Interventions
VXA-G1.1-NN, Placebo Tablets, Norovirus GI.1 Norwalk Virus Inoculum
Biological · Other
Lead sponsor
Vaxart
Industry
Eligibility
18 Years to 49 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Cypress, California
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Phase 2 Interventional Results available

Interpretation Training to Reduce Anxiety: Evaluating Technology-based Delivery Models and Methods to Reduce Attrition

NCT03498651
View directory record Official record
Conditions
Anxiety
Interventions
Cognitive Bias Modification - Interpretation training, Coaching, Online psychoeducation about anxiety
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
1,748 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Tryptophan MRI in People With Schizophrenia and Healthy Controls

NCT02067975
View directory record Official record
Conditions
Schizophrenia
Interventions
Tryptophan, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 55 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 25, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Scalable Model for Promoting Functioning and Well-Being Among Veterans With a History of Mental Health Challenges Via Meaningful Social Interactions: Project V-SPEAK!

NCT05506839
View directory record Official record
Conditions
Depression, Anxiety, PTSD
Interventions
Intervention (videoconferencing)
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 8, 2023 · Synced Oct 25, 2026, 10:08 AM EDT