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ClinicalTrials.gov public records Last synced Oct 26, 2026, 6:38 AM EDT

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Showing 625–648 of 1,539 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Challenge Clear all
Completed Phase 4 Interventional Results available

Phase 3/4 Study of a Recombinant Protein-Free Factor VIII (rAHF-PFM): Comparison of Continuous Infusion Versus Intermittent Bolus Infusion in Hemophilia A Subjects Undergoing Major Orthopedic Surgery

NCT00357656
View directory record Official record
Conditions
Hemophilia A
Interventions
Recombinant Protein-Free Factor VIII (rAHF-PFM)
Drug
Lead sponsor
Baxalta now part of Shire
Industry
Eligibility
18 Years to 70 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
10
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Chicago, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 4 Interventional Results available

Evaluation of the Efficacy of Topical Ophthalmic Steroids in a Modified Conjunctival Allergen Challenge (CAC) Model

NCT01534195
View directory record Official record
Conditions
Allergic Conjunctivitis
Interventions
Prednisolone Sodium Phosphate Ophthalmic Solution 1%, Tears Naturale II Ophthalmic Solution
Drug
Lead sponsor
ORA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 26, 2019 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Caloric Content and Timing of Meal on Postprandial Substrate Oxidation and Pulse Wave Analysis

NCT07122765
View directory record Official record
Conditions
Feeding, Metabolism, Indirect Calorimetry, Blood Flow Velocity, Pulse Wave Analysis, Pulse Wave Velocity, Carbohydrate Metabolism, Fatty Acid Metabolism, Healthy Participants
Interventions
Mixed Meal Feeding Challenge
Other
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Recruiting Phase 2 Interventional

Evaluation of TL-925 for the Treatment of Allergic Conjunctivitis

NCT06686472
View directory record Official record
Conditions
Allergic Conjunctivitis
Interventions
TL-925, Placebo
Drug
Lead sponsor
Telios Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Oct 26, 2026, 6:38 AM EDT
Recruiting Not applicable Interventional

BID LTM Digital Intervention in Aging

NCT06916221
View directory record Official record
Conditions
Long-Term Memory, Inhibitory Control, Mild Cognitive Impairment
Interventions
Long Term Memory, Worder
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years to 85 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of TT301 on Cytokine Levels Post Endotoxin Challenge

NCT01357421
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
TT301, Placebo
Drug
Lead sponsor
OPKO Health, Inc.
Industry
Eligibility
18 Years to 40 Years · Male only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 6, 2013 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using Self-Motivating Messages to Encourage People to Exercise More

NCT02903849
View directory record Official record
Conditions
Physical Activity
Interventions
Drafting Motivational Messages, Control Reminders, Treatment Reminders
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
324 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Oct 26, 2026, 6:38 AM EDT
Active, not recruiting Not applicable Interventional

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

NCT06872164
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Opioid Use Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Homologous Re-infection With Dengue 1 or Dengue 3

NCT05967455
View directory record Official record
Conditions
Dengue
Interventions
Dengue virus 1 Live Virus Human Challenge (DENV-1-LVHC), Dengue virus 3 Live Virus Human Challenge (DENV-3-LVHC)
Biological
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
18 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Oct 26, 2026, 6:38 AM EDT
Terminated Not applicable Interventional

Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)

NCT02742974
View directory record Official record
Conditions
Critical Illness, Trauma
Interventions
Device: FloTrac™ and EV1000™, Volume Challenge, Vasopressor Therapy, Inotropic Therapy
Device · Other · Drug
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Factors Involved in Dymista's Superior Clinical Efficacy in the Treatment of Seasonal Allergic Rhinitis

NCT02402465
View directory record Official record
Conditions
Allergic Rhinitis
Interventions
Placebo, Fluticasone propionate, Fluticasone/Azelastine nasal spray, Nasal Allergen Challenge
Drug · Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 55 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 1 Interventional

Experimental PfSPZ Vaccine in Adults Without Malaria

NCT01441167
View directory record Official record
Conditions
Malaria, Prevention and Control, Acquired Immunity
Interventions
PfSPZ
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 45 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Research Evaluating Sleep & Trends for Universal Prevention

NCT04783519
View directory record Official record
Conditions
Insomnia, Alcohol Use, Unspecified, Marijuana Use
Interventions
Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 24 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 7, 2024 · Synced Oct 26, 2026, 6:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching

NCT07766811
View directory record Official record
Conditions
Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
Interventions
Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment
Behavioral
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional Results available

Managing Asthma Patients With AMAZE™: A Novel Disease Management Platform

NCT04868500
View directory record Official record
Conditions
Asthma
Interventions
AMAZE™ Application, AMAZE™ Dashboard
Device
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional

Self-Acceptance and Supportive Accountability for Active Living Among Adults Receiving Chemotherapy

NCT07819045
View directory record Official record
Conditions
Invasive Breast Carcinoma, Gynecologic Malignancies
Interventions
Acceptance- and Mindfulness-Based Intervention
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 99 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 21, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Changes in Pediatric OSA

NCT05368077
View directory record Official record
Conditions
Pediatric Obstructive Sleep Apnea
Interventions
Adenotonsillectomy
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
7 Years to 12 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 29, 2024 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Behavioral Activation in Orthopaedic Trauma Patients: A Pilot Study

NCT04426981
View directory record Official record
Conditions
Fractures, Bone
Interventions
Behavioral Activation
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Oct 26, 2026, 6:38 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Stress Phenotypes and Preterm Birth

NCT05229666
View directory record Official record
Conditions
Preterm Birth, Inflammation, Stress, Mental Health Issue
Interventions
Cognitive Challenge
Other
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Not yet recruiting Phase 4 Interventional

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

NCT07786896
View directory record Official record
Conditions
E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions
Nicotine Replacement Therapies, Brief Behavioral Counseling
Drug · Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Greenville, North Carolina • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

CampETEC Hyperimmune Bovine Colostrum (HBC)

NCT06122870
View directory record Official record
Conditions
Healthy Volunteer
Interventions
CampETEC HBC product, ProMilk 85, C. jejuni CG8421 Challenge strain
Biological
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 22, 2025 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes

NCT00835861
View directory record Official record
Conditions
Non Insulin Dependent Diabetes, Pregnancy
Interventions
Metformin, Insulin
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older · Female only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 25, 2017 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Not applicable Interventional

The Community United to Challenge Asthma

NCT01061424
View directory record Official record
Conditions
Asthma
Interventions
community health worker, mailed information
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
5 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 15, 2012 · Synced Oct 26, 2026, 6:38 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

CP-481,715 Nickel Allergy Study.

NCT00141180
View directory record Official record
Conditions
Dermatitis, Allergic Contact
Interventions
CP-481,715
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
4
States / cities
Ann Arbor, Michigan • New York, New York • Austin, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2006 · Synced Oct 26, 2026, 6:38 AM EDT