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ClinicalTrials.gov public records Last synced Oct 27, 2026, 1:03 PM EDT

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Showing 865–888 of 1,541 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Challenge Clear all
Completed Phase 2Phase 3 Interventional Results available

Efficacy of AC-170 for the Treatment of Allergic Conjunctivitis in the Conjunctival Allergen Challenge (CAC) Model

NCT01332188
View directory record Official record
Conditions
Allergic Conjunctivitis
Interventions
AC-170 0.05%, AC-170 0.1%, AC-170 0.24%, AC-170 0%
Drug
Lead sponsor
Aciex Therapeutics, Inc.
Industry
Eligibility
10 Years and older
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Phase I/II Trial of Modified Vaccinia Virus Ankara (MVA) Vaccine Against Smallpox

NCT00053742
View directory record Official record
Conditions
Healthy
Interventions
Modified Vaccinia Virus Ankara TBC-MVA
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 27, 2026, 1:03 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effectiveness of an eHealth Intervention for Uptake of Cervical Cancer Screening in Hispanic Women

NCT06741241
View directory record Official record
Conditions
Cervical Cancer Screening
Interventions
eHealth Promotora, eHealth Healthy Nutrition
Behavioral
Lead sponsor
Florida A&M University
Other
Eligibility
21 Years to 65 Years · Female only
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Recruiting Not applicable Interventional

Motor-Cognitive Training for Motoric Cognitive Risk Syndrome

NCT07223905
View directory record Official record
Conditions
Motoric Cognitive Risk Syndrome
Interventions
Virtual Reality Treadmill Training, Treadmill Training
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Terminated Phase 2 Interventional Results available

A Phase 2A Study to Evaluate the Safety and Effect on Exercise Challenge Testing of MEDI-528 in Adults With Asthma

NCT00590720
View directory record Official record
Conditions
Asthma
Interventions
MEDI528 50 mg, PLACEBO
Biological · Other
Lead sponsor
MedImmune LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
9
States / cities
San Diego, California • Denver, Colorado • Waterbury, Connecticut + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2014 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 2 Interventional

Evaluation of the Onset and Duration of Action of RX-10045 in Allergic Conjunctivitis

NCT01639846
View directory record Official record
Conditions
Allergic Conjunctivitis
Interventions
RX-10045, Vehicle for RX-10045 arm
Drug
Lead sponsor
C.T. Development America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Andover, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2013 · Synced Oct 27, 2026, 1:03 PM EDT
Recruiting Early Phase 1 Interventional

LYmph Node eXamination in Cat Allergen Immunotherapy

NCT07447869
View directory record Official record
Conditions
Allergy
Interventions
Intradermal cat allergen challenge
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of Three or Five Administrations of GAP3KO Sporozoites

NCT03168854
View directory record Official record
Conditions
Plasmodium Falciparum Infection
Interventions
Genetically-attenuated p52-/p36-/sap1- Plasmodium falciparum parasite (GAP3KO) strain, Malaria challenge
Biological · Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 50 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Oct 27, 2026, 1:03 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Planetary Health and Environmental Justice in Construction Career Education

NCT07315919
View directory record Official record
Conditions
Health Knowledge, Environmental Exposure, Attitude, Practice
Interventions
Community-Centered Design Curriculum with EJT, Traditional Technical Curriculum
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Healthy Motivations for Moms-to-be Study

NCT03063528
View directory record Official record
Conditions
Weight Gain, Pregnancy, Stress, Emotional, Exercise, Nutrition
Interventions
Healthy Eating and Physical Activity, Stress Reduction and Management
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
20 Years to 35 Years · Female only
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 15, 2018 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Not applicable Interventional

Addressing Mental Health Disparities in Refugee Children

NCT03796065
View directory record Official record
Conditions
Family Research
Interventions
FSI-R Treatment
Behavioral
Lead sponsor
Boston College
Other
Eligibility
7 Years and older
Enrollment
354 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
Lewiston, Maine • Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 27, 2026, 1:03 PM EDT
Recruiting No phase listed Observational

Microglia Activation in Asthma

NCT04307667
View directory record Official record
Conditions
Asthma
Interventions
Whole lung antigen challenge (WLAC), [18F]FEPPA
Biological · Radiation
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

HRIPT for Collagen Dressing

NCT06283173
View directory record Official record
Conditions
Skin Sensitisation
Interventions
ColActive Plus Collagen Matrix Dressing
Device
Lead sponsor
Covalon Technologies Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Early Phase 1 Interventional Results available

Study of a Topical Nasal Spray to Ease the Symptoms of Hayfever

NCT01500629
View directory record Official record
Conditions
Rhinitis, Allergic, Seasonal
Interventions
C-1266-7, C-1266-6 (placebo)
Device
Lead sponsor
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Assess the Electrophysiology, Safety, Tolerability, and Pharmacokinetics of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

NCT03771586
View directory record Official record
Conditions
Healthy Volunteer
Interventions
SAGE-718, Placebo
Drug
Lead sponsor
Supernus Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Long Beach, California • Berlin, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2025 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 2 Interventional

Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route

NCT03845231
View directory record Official record
Conditions
Influenza
Interventions
Flucelvax(R), Human Challenge virus
Biological · Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 55 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 10, 2020 · Synced Oct 27, 2026, 1:03 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients

NCT04689477
View directory record Official record
Conditions
COVID-19, Endothelial Function
Interventions
Vascular occlusion test
Device
Lead sponsor
Corporacion Parc Tauli
Other
Eligibility
18 Years and older
Enrollment
612 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Single Dose Texas 2017 (H3N2) Challenge Study

NCT06476275
View directory record Official record
Conditions
Influenza Viral Infections
Interventions
Influenza A/Texas/71/2017 (H3N2), Sham placebo
Biological
Lead sponsor
Duke University
Other
Eligibility
18 Years to 46 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Safety Study of a Human Metapneumovirus Challenge Virus in Healthy Adults

NCT01109329
View directory record Official record
Conditions
Human Metapneumovirus
Interventions
HMPV challenge virus
Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 49 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 3, 2013 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Not applicable Interventional

Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy

NCT05220137
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Modified A-B-C: Working with Events, Thoughts, and Feelings, Challenging Questions, Patterns of Problematic Thinking, Challenging Beliefs, Veteran's choice of Module (Safety/Trust/Power and Control/Esteem/Intimacy)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Ann Arbor, Michigan • Cincinnati, Ohio • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Not applicable Interventional

Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain

NCT05373745
View directory record Official record
Conditions
Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
Interventions
Active Brains 1, Active Brains 2
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 4 Interventional Results available

BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study

NCT05683821
View directory record Official record
Conditions
Quitting Smoking, Smoking Cessation, Smoking, Cigarette
Interventions
Text message smoking treatment, Nicotine replacement therapy sampling, Wisconsin Tobacco QuitLine Referral, Referral to Primary Care Provider, BREATHE 2 Cessation Study, Additional modalities to learn about and request treatment
Behavioral · Drug · Combination Product
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
12,376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Serious Illness Communication Project

NCT01786811
View directory record Official record
Conditions
End of Life Care, Cancer
Interventions
Training
Behavioral
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
994 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Oct 27, 2026, 1:03 PM EDT
Completed Phase 4 Interventional Results available

Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety

NCT02153944
View directory record Official record
Conditions
Anxiety Disorder
Interventions
Propranolol, Methylphenidate, Placebo
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 50 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Oct 27, 2026, 1:03 PM EDT