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ClinicalTrials.gov public records Last synced Sep 30, 2026, 7:35 AM EDT

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Showing 25–48 of 61 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Chlorhexidine - Isopropyl alcohol Clear all
Completed Phase 4 Interventional Results available

Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions

NCT00739583
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
CHG 2% w/v and IPA 70% v/v, Iodophor 0.7% and IPA 74% w/w
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

In Vivo Patient Preoperative Skin Prep Persistence

NCT02447497
View directory record Official record
Conditions
Bacterial Recovery of Skin Flora Post-Product Application
Interventions
3M CHG/IPA Surgical Skin Preparation - Abdominal Region, Normal Saline - Abdominal Region, 3M CHG/IPA Surgical Skin Preparation - Inguinal Region, Normal Saline - Inguinal Region
Drug · Other
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Results available

Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections

NCT00290290
View directory record Official record
Conditions
Postoperative Wound Infection
Interventions
chlorhexidine-alcohol, Povidone-Iodine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
849 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
6
States / cities
West Roxbury, Massachusetts • Durham, North Carolina • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2014 · Synced Sep 30, 2026, 7:35 AM EDT
Not listed Not applicable Interventional

Umbilical Cord Care for the Prevention of Colonization

NCT01893060
View directory record Official record
Conditions
Line Insertion Site, Central Line-associated Bloodstream Infection (CLABSI)
Interventions
Povidone-Iodine, Chlorhexidine gluconate, Pluronic Cream, control
Drug · Other
Lead sponsor
University of Virginia
Other
Eligibility
Up to 7 Days
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 2, 2013 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation

NCT03861780
View directory record Official record
Conditions
Bacteria Microflora Reduction
Interventions
Project X 26ml, Project X 5.1ml, Prevantics Maxi Swabstick
Drug
Lead sponsor
Professional Disposables International, Inc.
Industry
Eligibility
18 Years and older
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Oct 22, 2021 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Preoperative Skin Preparation Evaluation

NCT00636480
View directory record Official record
Conditions
Topical Antisepsis
Interventions
Chlorhexidine gluconate, ChloraPrep One Step, Sterile saline
Drug
Lead sponsor
C. R. Bard
Industry
Eligibility
16 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Surgical Preparation Solutions in Knee Surgery

NCT01857349
View directory record Official record
Conditions
Arthroplasty, Replacement
Interventions
Chlora Prep, Dura Prep
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 89 Years
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2020
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2020 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs

NCT06733506
View directory record Official record
Conditions
Opioid Use Disorder, Injection Drug Use, Skin and Soft Tissue Infections (SSTIs)
Interventions
Chlorhexidine gluconate, Isopropyl Alcohol 70% Topical Application Solution, Skin Prep Before Injecting Recreational/Street Drugs
Drug · Behavioral
Lead sponsor
Gabriel John Culbert
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 3, 2025 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In-vivo Efficacy of Patient Preoperative Prep

NCT02831998
View directory record Official record
Conditions
Surgical Skin Preparation
Interventions
ZuraPrep, ChloraPrep, ZP Vehicle
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Safety of Gebauer's Pain Ease and Gebauer's Ethyl Chloride

NCT04207710
View directory record Official record
Conditions
Spray, Pain, Safety Issues
Interventions
Gebauer's Pain Ease Top Aerosol Mist Spray, Gebauer's Ethyl Chloride
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
Not listed
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Utility of Placental/Umbilical Cord Blood in Early Onset Neonatal Sepsis in Very Low Birth Weight Infants

NCT03694613
View directory record Official record
Conditions
Preterm Infant, Early-Onset Neonatal Sepsis, Umbilical Cord
Interventions
Placental/Umbilical Cord Blood sample
Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
Up to 1 Day
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Sep 30, 2026, 7:35 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)

NCT00896402
View directory record Official record
Conditions
Infection
Interventions
Skin antisepsis with chlorhexidine, povidone-iodine
Drug
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
2
States / cities
Syosset, New York • Valley Stream, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2015 · Synced Sep 30, 2026, 7:35 AM EDT
Completed No phase listed Observational

Surgical Prep in Hand Surgery

NCT01676051
View directory record Official record
Conditions
Surgical Scrubbing, Disinfection
Interventions
Skin culture
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 89 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 31, 2017 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In-vivo Efficacy of Patient Preoperative Prep, ZuraPrep (ZP)

NCT03782103
View directory record Official record
Conditions
Surgical Skin Preparation
Interventions
ZuraPrep Clear Solution, ChloraPrep, ZuraPrep Vehicle
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics

NCT00692484
View directory record Official record
Conditions
Healthy
Interventions
Chlorhexidine gluconate, Povidone iodine
Drug
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years to 90 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Nov 26, 2025 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Blue Light Therapy of C. Acnes

NCT04300010
View directory record Official record
Conditions
Acne
Interventions
5% Topical Benzoyl Peroxide Gel, Blue Light Therapy
Drug · Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Not applicable Interventional

Efficacy of Surgical Preparations in Lumbar Spine Surgery

NCT01105195
View directory record Official record
Conditions
Infection
Interventions
DuraPrep, ChloraPrep
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 17, 2010 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Test for Pre Operative Skin Preparations

NCT00799812
View directory record Official record
Conditions
Topical Antisepsis
Interventions
CHG 2% w/v & IPA 70% v/v, swabstick (3 @ once)., CHG 2% w/v & IPA 70% v/v swab applied sequentially, Aqueous CHG 4% w/v applied according to mfr's directions, Sterile swabstick with sterile water (3 @ once), Sterile swabstick with sterile water (one-at-a-time)
Drug · Other
Lead sponsor
C. R. Bard
Industry
Eligibility
16 Years and older
Enrollment
335 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Not applicable Interventional Results available

Retrospective Independent Safety Review of Closed Irrisept Study

NCT05359666
View directory record Official record
Conditions
Adverse Events
Interventions
Irrisept, Standard of Care
Device
Lead sponsor
Irrimax Corporation
Industry
Eligibility
Not listed
Enrollment
592 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
17
States / cities
Tucson, Arizona • Los Angeles, California • Denver, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Sep 30, 2026, 7:35 AM EDT
Terminated Phase 4 Interventional

ChloraPrep Versus Betadine for Elective Knee Replacement Surgery

NCT01184196
View directory record Official record
Conditions
Arthroplasty, Knee Replacement, Replacement, Total Knee, Total Knee Replacement
Interventions
Swab area with Betadine, Swab area with ChloraPrep
Drug
Lead sponsor
Central DuPage Hospital
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 16, 2013 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Results available

Efficacy of TAP Block in Cesarean Section Patients

NCT03493828
View directory record Official record
Conditions
Pain Control
Interventions
TAP block using Bupivacaine 0.5%, TAP block using Bupivacaine 0.25%, TAP block using Normal Saline
Procedure
Lead sponsor
New York Presbyterian Brooklyn Methodist Hospital
Other
Eligibility
Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Perioperative Patient Skin Antiseptic Preparation Evaluation

NCT04756804
View directory record Official record
Conditions
Surgical Site Infection
Interventions
70% v/v Isopropyl Alcohol Surgical Solution, 2%w/v Chlorhexidine Gluconate / 70% v/v Isopropyl Alcohol
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Sep 30, 2026, 7:35 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections

NCT05920122
View directory record Official record
Conditions
Surgical Site Infection, Cesarean Section; Infection
Interventions
2% Chlorhexidine gluconate with 70% alcohol, 4% Chlorhexidine Gluconate aqueous solution
Drug
Lead sponsor
Hyagriv Simhan
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
1,398 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 30, 2026, 7:35 AM EDT
Not listed Not applicable Interventional

Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With Hip OA Compared to Intra-articular Steroid Injections

NCT04329884
View directory record Official record
Conditions
Osteoarthritis, Hip
Interventions
Cooled RFA treatment with COOLIEF* device, intra-articular corticosteroid injection
Procedure · Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 1, 2020 · Synced Sep 30, 2026, 7:35 AM EDT