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ClinicalTrials.gov public records Last synced Oct 7, 2026, 11:21 AM EDT

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Showing 25–48 of 65 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Chlorhexidine gluconate (CHG) Clear all
Completed Phase 4 Interventional Accepts healthy volunteers

Evaluation of Chlorhexidine Gluconate Concentration on Skin of Human Subjects Following Multiple Application Times

NCT04235985
View directory record Official record
Conditions
General Skin Cleansing
Interventions
Chlorhexidine Gluconate with HUBS
Combination Product
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Irritation and Sensitization of Chlorhexidine Gluconate (CHG) Cloth

NCT02224625
View directory record Official record
Conditions
Surgery
Interventions
2% CHG Cloth solution, Vehicle Cloth, Active Comparator, Saline, SLS
Drug · Device · Other
Lead sponsor
Medline Industries
Industry
Eligibility
16 Years and older
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Butte, Montana
Source: ClinicalTrials.gov public record
Updated Mar 9, 2017 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of Peripheral Nerve Catheter Securement Techniques at the Insertion Site in Healthy Volunteers

NCT03375190
View directory record Official record
Conditions
Regional Anesthesia Morbidity
Interventions
Dressing, Dressing + adhesive, Experimental: Dressing + adhesive + strips (parallel), Experimental: Dressing + adhesive + strips (perpend), Experimental: Dressing + adhesive + strips + benzoin, Experimental: Dressing + adhesive + strips + spray
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 14, 2018 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 4 Interventional Results available

Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions

NCT00739583
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip
Interventions
CHG 2% w/v and IPA 70% v/v, Iodophor 0.7% and IPA 74% w/w
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 10, 2013 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Not applicable Interventional Results available

Retrospective Independent Safety Review of Closed Irrisept Study

NCT05359666
View directory record Official record
Conditions
Adverse Events
Interventions
Irrisept, Standard of Care
Device
Lead sponsor
Irrimax Corporation
Industry
Eligibility
Not listed
Enrollment
592 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
17
States / cities
Tucson, Arizona • Los Angeles, California • Denver, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Not applicable Interventional Results available

Active Bathing to Eliminate Infection (ABATE Infection) Trial

NCT02063867
View directory record Official record
Conditions
Healthcare Associated Infections, Methicillin Resistant Staphylococcus Aureus, Multi Drug Resistant Organisms
Interventions
Arm 2: Decolonization
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
12 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
52
States / cities
West Hills, California • Thornton, Colorado • Bradenton, Florida + 42 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2019 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In-vivo Efficacy of Patient Preoperative Prep

NCT02831998
View directory record Official record
Conditions
Surgical Skin Preparation
Interventions
ZuraPrep, ChloraPrep, ZP Vehicle
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
440 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Not applicable Interventional Results available

Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections

NCT00779246
View directory record Official record
Conditions
Staphylococcal Infections
Interventions
Nasal swabs for MRSA culture, Chlorhexidine gluconate, Contact isolation
Other · Drug
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years and older
Enrollment
1,518 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Trial of Drain Antisepsis After Tissue Expander Breast Reconstruction

NCT01286168
View directory record Official record
Conditions
Nonmalignant Breast Conditions, Breast Cancer
Interventions
Sodium hypochlorite (Dakin's Solution), Chlorhexidine gluconate disk, Control, Occlusive Adhesive Dressing
Device · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
2
States / cities
San Francisco, California • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Patient Preoperative Prep

NCT02831816
View directory record Official record
Conditions
Surgical Skin Preparation
Interventions
ZuraPrep, ChloraPrep, ZP Vehicle
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
640 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Jul 16, 2021 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 4 Interventional Results available

Project PROTECT: Protecting Nursing Homes From Infections and Hospitalization

NCT03118232
View directory record Official record
Conditions
Hospitalization, Infection
Interventions
Chlorhexidine gluconate (CHG), Iodophor (10% povidone-iodine)
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
13,952 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
28
States / cities
Anaheim, California • Bellflower, California • Capistrano Beach, California + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2023 · Synced Oct 7, 2026, 11:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Impact of Irrisept in Reducing Urinary Tract Infection During Urethral Catheter Removal.

NCT07239219
View directory record Official record
Conditions
Urinary Tract Infection, Antibiotic, Catheter Infection
Interventions
0.05% Chlorhexidine Gluconate, Normal Saline
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Human Repeat Insult Patch Test of Wound Dressings

NCT01368146
View directory record Official record
Conditions
Skin Sensitization
Interventions
IV Clear™, Tegaderm CHG™, Silicone Vehicle Control Dressing
Device
Lead sponsor
Covalon Technologies Inc.
Industry
Eligibility
18 Years to 100 Years
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Oct 7, 2026, 11:21 AM EDT
Recruiting Not applicable Interventional

Wound Irrigation With Saline Versus Hypodilute-chlorhexidine After Cesarean Section (WISHES Study)

NCT06339203
View directory record Official record
Conditions
Cesarean Section Complications, Cesarean Section; Infection
Interventions
Irrisept, Normal Saline
Device · Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older · Female only
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Not applicable Interventional

Bacterial Decolonization Within Dyads

NCT06541145
View directory record Official record
Conditions
Bacterial Colonization
Interventions
Mupirocin, Chlorhexidine baths
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Antimicrobial Activity of IV Clear™ Dressing - Prevention of Antimicrobial Regrowth

NCT01368120
View directory record Official record
Conditions
Skin Flora Infection
Interventions
IV Clear™ Dressing, Tegaderm CHG™, Silicone Vehicle Control Dressing
Device
Lead sponsor
Covalon Technologies Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Miamiville, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In-vivo Efficacy of Patient Preoperative Prep, ZuraPrep (ZP)

NCT03782103
View directory record Official record
Conditions
Surgical Skin Preparation
Interventions
ZuraPrep Clear Solution, ChloraPrep, ZuraPrep Vehicle
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Sterling, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Oct 7, 2026, 11:21 AM EDT
Withdrawn Not applicable Interventional

The Efficacy of Chlorhexidine Gluconate Gel Dressing in Preventing Surgical Drain Site Infection

NCT04656145
View directory record Official record
Conditions
Drain Site Complication
Interventions
3M™ Tegaderm™ CHG Chlorhexidine Gluconate I.V. Securement Dressing
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 6, 2023 · Synced Oct 7, 2026, 11:21 AM EDT
Terminated Phase 4 Interventional Results available

Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients

NCT03401749
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Chlorhexidine Gluconate 2% Wipe, Theraworx Bath Wipes
Drug · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 64 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 2, 2022 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In Vivo Efficacy Study of Patient Preoperative Preps

NCT02203591
View directory record Official record
Conditions
Bacterial Reduction Post-product Application
Interventions
3M CHG/IPA Prep C, 3M CHG/IPA Prep CH, ChloraPrep, Normal Saline
Drug
Lead sponsor
3M
Industry
Eligibility
18 Years and older
Enrollment
738 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Oct 7, 2026, 11:21 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers

Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™

NCT02221232
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Chloraprep, ZuraPrep, ZuraPrep Vehicle
Drug
Lead sponsor
Zurex Pharma, Inc.
Industry
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Jul 18, 2016 · Synced Oct 7, 2026, 11:21 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

CHG Dressings in Children With Central Lines

NCT01955226
View directory record Official record
Conditions
Children With Central Venous Access
Interventions
Tegaderm CHG clear dressing, Standard clear Tegaderm dressing
Other
Lead sponsor
Yale University
Other
Eligibility
2 Months to 18 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 13, 2016 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation

NCT03861780
View directory record Official record
Conditions
Bacteria Microflora Reduction
Interventions
Project X 26ml, Project X 5.1ml, Prevantics Maxi Swabstick
Drug
Lead sponsor
Professional Disposables International, Inc.
Industry
Eligibility
18 Years and older
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Oct 22, 2021 · Synced Oct 7, 2026, 11:21 AM EDT
Completed Not applicable Interventional Results available

Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation

NCT02395614
View directory record Official record
Conditions
Breast Cancer
Interventions
Chlorhexidine irrigation, triple antibiotic irrigation
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 81 Years · Female only
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 26, 2022 · Synced Oct 7, 2026, 11:21 AM EDT