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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Chocolate Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Black Forest Cocoa Flavanol Supplementation and Health Trial

NCT07747714
View directory record Official record
Conditions
Endothelial Function, Oxidative Stress, Inflamation, Vascular Health
Interventions
Cocoa Flavanol Supplement, Low-Flavanol Control Powder
Dietary Supplement
Lead sponsor
The Black Forest LLC
Industry
Eligibility
30 Years to 75 Years · Male only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional

Flavanol-Rich Cocoa and Cerebral Blood Flow

NCT00825695
View directory record Official record
Conditions
Hypertension, Diabetes
Interventions
cocoa
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 29, 2014 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flavonoid Effect on Activation and Stimulation of Thrombocytes, hsCRP and Lipid Profile

NCT00559663
View directory record Official record
Conditions
Healthy
Interventions
Green tea, 70% dark chocolate
Dietary Supplement
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2007 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function

NCT01671514
View directory record Official record
Conditions
Heart Failure, Type 2 Diabetes
Interventions
Epicatechin-enriched dark chocolate, Low-epicatechin dark chocolate
Dietary Supplement · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
40 Years to 70 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 2, 2015 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Food Matrix Effect on Flavanol Absorption, Metabolism and Excretion: Methylxanthines

NCT03526107
View directory record Official record
Conditions
Healthy
Interventions
CF Control, CF-Theobromine, CF-Caffeine
Other
Lead sponsor
University of California, Davis
Other
Eligibility
25 Years to 60 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
2
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2022 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Validating the "Foods for Health" Portfolio of Functional Food Products

NCT02341924
View directory record Official record
Conditions
Hypercholesterolemia
Interventions
Portfolio of functional foods, Control foods
Other
Lead sponsor
University of Manitoba
Other
Eligibility
21 Years to 64 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 19, 2023 · Synced Sep 10, 2026, 3:17 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain's Response to Chocolate

NCT03364413
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Chocolate
Other
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Dec 7, 2023 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Xoçai Antioxidant Supplements on Atherosclerosis Risk Factors

NCT00666250
View directory record Official record
Conditions
Hypertension, Dyslipidemia, Hyperglycemia
Interventions
Xocai Activ drink
Dietary Supplement
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 95 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional

Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Obesity and HFpEF

NCT03966755
View directory record Official record
Conditions
Obesity, Heart Failure With Normal Ejection Fraction
Interventions
UFA dietary recommendations
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Effect of Funk It Cycle Bites on PMS

NCT05900024
View directory record Official record
Conditions
Premenstrual Syndrome
Interventions
Funk It Cycle Bites
Other
Lead sponsor
Funk It Wellness
Industry
Eligibility
18 Years to 40 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Phase 2 Interventional Results available

CHOCOlate MeLatonin for AdolescenT MigrainE

NCT03597529
View directory record Official record
Conditions
Migraine
Interventions
Melatonin
Drug
Lead sponsor
Amy Gelfand
Other
Eligibility
3 Years to 17 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Protein Source on Appetite Control, Satiety, and Subsequent Food Intake: A Clinical Screening Study

NCT03595436
View directory record Official record
Conditions
Appetitive Behavior
Interventions
Pea Protein-20g, Pea Protein-30g, Pea Protein-40g, Whey Protein-20g, Carbohydrate Control
Dietary Supplement
Lead sponsor
Purdue University
Other
Eligibility
20 Years to 40 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Sep 10, 2026, 3:17 PM EDT
Not listed Not applicable Interventional

Metabolomics Initiative: Mediterranean-amplified vs Habitual Western Diet on Food Signatures, Health, and Microbiome

NCT05500976
View directory record Official record
Conditions
Dietary Habits
Interventions
Semi-controlled dietary intervention - Western, Semi-controlled dietary intervention - MiniMed
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
30 Years to 69 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 26, 2024 · Synced Sep 10, 2026, 3:17 PM EDT
Terminated Not applicable Interventional Results available

Flavanol Augmentation for Antidepressant Non-Responsive Late Life Depression

NCT02943096
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
CocoaVia, Placebo
Dietary Supplement · Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2019 · Synced Sep 10, 2026, 3:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Peanut Butter on Gut and Metabolic Health

NCT06916936
View directory record Official record
Conditions
Dysbiosis
Interventions
Creamy Richards 100% Peanuts! Creamy Natural Peanut Butter, Cadbury Milk Chocolate Spread
Other
Lead sponsor
Florida State University
Other
Eligibility
6 Years to 13 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity

NCT02490527
View directory record Official record
Conditions
Statin Intolerance
Interventions
Pure epicatechin capsules (50mg), Simvastatin (40mg), Placebo
Dietary Supplement · Drug · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
30 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 10, 2026, 3:17 PM EDT
Not yet recruiting Not applicable Interventional

Elucidating the Effect of Dietary Stearic Acid on the Regional Heterogeneity of the Gut Microbiome and Metabolome: Focus on Bile Acid Metabolism (SAMPill Study)

NCT07766915
View directory record Official record
Conditions
CVD Risk
Interventions
High Palmitic Acid Diet, High Stearic Acid Diet
Other
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 10, 2026, 3:17 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Craving & Decision-Making

NCT06440577
View directory record Official record
Conditions
Decision Making
Interventions
Audio-visual stimuli (Neutral-Relaxing), Audio-visual stimuli (Drug), Audio-visual stimuli (Non-Food), Audio-visual stimuli (Food)
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

COcoa Supplement and Multivitamin Outcomes Study

NCT02422745
View directory record Official record
Conditions
Cardiovascular Disease, Cancer
Interventions
Cocoa extract, Multivitamin, Cocoa extract placebo, Multivitamin placebo
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
60 Years and older
Enrollment
21,442 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional

Effects of Polyphenolic-rich Dark Chocolate/Cocoa and Almonds on Cardiovascular Disease Risk Factors

NCT01882881
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
Healthy American Control Diet, Dark Chocolate/Cocoa Diet, Almond Diet, Dark Chocolate/Cocoa + Almond Diet
Other
Lead sponsor
Penn State University
Other
Eligibility
30 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interaction of Salivary Proteins and Polyphenols

NCT03501238
View directory record Official record
Conditions
Diet Habit, Diet Modification, Taste, Altered, Saliva Altered
Interventions
Chocolate Milk, Chocolate milk substitute, Chocolate milk substitute with gelatin
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 45 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Sep 10, 2026, 3:17 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Beef Versus Whey Protein: The Gut Showdown Self-Experiment

NCT07477223
View directory record Official record
Conditions
Digestion
Interventions
Beef protein, Chocolate whey protein
Dietary Supplement
Lead sponsor
Efforia, Inc
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 10, 2026, 3:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Cocoa Shot on the Human Brain

NCT01924481
View directory record Official record
Conditions
Caffeine, Flavonoids
Interventions
High Caffeine, Low caffeine, High theobromine, low theobromine, No theobromine
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 38 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Sep 10, 2026, 3:17 PM EDT
Recruiting Not applicable Interventional

Cocoa Extract for Migraine Trial

NCT06808230
View directory record Official record
Conditions
Migraine
Interventions
Cocoa extract, Cocoa extract placebo
Dietary Supplement
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 10, 2026, 3:17 PM EDT