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Showing 25–39 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cig Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Manipulating E-Cigarette Nicotine to Promote Public Health

NCT06448351
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Biospecimen Collection, Carbon Monoxide Measurement, Vaping session, Survey Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
375 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 6, 2026, 2:56 PM EDT
Recruiting Not applicable Interventional

Harm Reduction for Smokers With Mental Illness

NCT06543407
View directory record Official record
Conditions
Tobacco Dependence
Interventions
SWITCH IT, E-cig Provision Only
Behavioral · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Louisville, Kentucky • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 6, 2026, 2:56 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Impact of Chronic E-Cigarette Usage on Microvascular Health

NCT06860698
View directory record Official record
Conditions
E-Cig Use
Interventions
E-cig use
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 29 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 6, 2026, 2:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

E-Cigarettes: Dynamic Patterns of Use and Health Effects

NCT02527980
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
No intervention: observation only
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Madison, Wisconsin • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Pharmacology of Electronic Cigarettes

NCT02470754
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Tobacco Cigarette, Electronic Cigarette
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH

NCT04449510
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Electronic Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

NCT02323438
View directory record Official record
Conditions
Smoking
Interventions
Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 6, 2026, 2:56 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense

NCT03700892
View directory record Official record
Conditions
Smoking, Healthy
Interventions
Cinnamaldehyde e-liquid, PG/VG e-liquid
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 40 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Sep 6, 2026, 2:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

NCT02730676
View directory record Official record
Conditions
Smoking
Interventions
Electronic Cigarette #1, Electronic Cigarette #2
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

NCT03072628
View directory record Official record
Conditions
Nicotine Dependence
Interventions
e-cig with nicotine, e-cig without nicotine, nicotine inhaler, sham control
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy

NCT02628964
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
e-cigarettes
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

NCT04090879
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 70 Years
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Providence, Rhode Island • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Not applicable Interventional Results available

Changes in Biomarkers Associated With Use of Electronic Cigarettes

NCT03084315
View directory record Official record
Conditions
Biomarkers
Interventions
E-Cig Zero Nicotine, E-Cig 24mg Nicotine
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Sep 6, 2026, 2:56 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Pharmacokinetic Study Comparing Nicotine Delivery From E-cigarettes and a Conventional Cigarette in Healthy Subjects

NCT02474849
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Use electronic cigarette or smoke conventional cigarette
Other
Lead sponsor
British American Tobacco (Investments) Limited
Industry
Eligibility
21 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2015 · Synced Sep 6, 2026, 2:56 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Vaping High vs. Low Nicotine E-Liquid

NCT04047836
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2023 · Synced Sep 6, 2026, 2:56 PM EDT