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Showing 1–17 of 17 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cigarette Brand Switching Clear all
Completed Not applicable Interventional Accepts healthy volunteers

BAT3221032: A Study to Evaluate the Effects of Switching From Cigarette Smoking to Using One of Five Variants of a Heated Tobacco Product on Biomarkers of Exposure and Biomarkers of Potential Harm in Healthy Subjects

NCT05142436
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A: Non-Combusted Cigarette Variant 42001402 and product use Mode B, Product B: Non-Combusted Cigarette Variant 42001399 and product use Mode B, Product C: Non-Combusted Cigarette Variant 42001401 and product use Mode B, Product D: Non-Combusted Cigarette Variant 40007386 and product use Mode B, Product E: Non-Combusted Cigarette Variant 42001402 and product use Mode A
Other
Lead sponsor
British American Tobacco (Investments) Limited
Industry
Eligibility
26 Years to 55 Years
Enrollment
806 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
18
States / cities
Bentonville, Arkansas • Little Rock, Arkansas • Rogers, Arkansas + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2022 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exploratory Study of Switching From Combustible Cigarettes to the BIDI E-cigarette

NCT05855343
View directory record Official record
Conditions
Smoking Cessation
Interventions
BIDI Stick e-cigarette
Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2024 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Results available

Impact of Switching to Non-Menthol Cigarettes Among Smokers

NCT03075839
View directory record Official record
Conditions
Tobacco Use
Interventions
Cigarette Brand Switching
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

NCT02415270
View directory record Official record
Conditions
Tobacco Smoking Behavior
Interventions
Reduced Nicotine Cigarettes, Reduced ROS/RNS, Control
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting

NCT01989156
View directory record Official record
Conditions
Smoking
Interventions
THS 2.2 Menthol (mTHS 2.2), Menthol Conventional Cigarette (mCC), Smoking Abstinence (SA)
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
22 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Daytona Beach, Florida • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors

NCT02000921
View directory record Official record
Conditions
Tobacco Addiction, Dual Tobacco Use
Interventions
VLNC cigarettes, Combusted Products, Non-combusted products, CN cigarettes
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of Unfiltered Cigarettes Among Committed Smokers

NCT03749876
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Smoking
Interventions
Unfiltered Cigarettes, Filtered Cigarettes
Other
Lead sponsor
San Diego State University
Other
Eligibility
21 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Marcos, California
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching From Usual Brand Cigarettes to a Tobacco-heating Cigarette or Snus

NCT02061917
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Tobacco-Heating Cigarette, Snus (Smokeless Tobacco), Tobacco-Burning Cigarette
Other
Lead sponsor
R.J. Reynolds Tobacco Company
Industry
Eligibility
28 Years to 55 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
5
States / cities
Daytona Beach, Florida • Boise, Idaho • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 16, 2016 · Synced Sep 3, 2026, 3:43 AM EDT
Active, not recruiting Not applicable Interventional

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

NCT07108166
View directory record Official record
Conditions
COPD, Smoking, Tobacco Use
Interventions
Cigarette, THS
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
40 Years and older
Enrollment
290 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
46
States / cities
Clearwater, Florida • Coral Gables, Florida • Davie, Florida + 24 more
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2

NCT02649556
View directory record Official record
Conditions
Smoking
Interventions
THS 2.2, CC
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
30 Years and older
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
19
States / cities
Tempe, Arizona • Clearwater, Florida • Daytona Beach, Florida + 16 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Sep 3, 2026, 3:43 AM EDT
Terminated Not applicable Interventional Results available

Impact of Cigarette and E-cigarette Flavors on Adult Smoking Behavior

NCT04009850
View directory record Official record
Conditions
Tobacco Use
Interventions
Cigarette Brand Switching, E-cigarette Flavor
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes

NCT03856515
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Nicotine Replacement, Questionnaire Administration, Electronic Cigarette
Drug · Other · Device
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years and older
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD231005 Nicotine Pouch Biomarkers of Exposure

NCT06303115
View directory record Official record
Conditions
Tobacco Use, Smoking
Interventions
Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine, Nicotine Pouch P1013218, 10 mg nicotine, Nicotine Pouch P1012919, 12 mg nicotine, Smoking Abstinence, Continued UB cigarette smoking
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems

NCT05423340
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
E-cigarette Flavor, Tobacco Free Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 3, 2026, 3:43 AM EDT
Terminated Not applicable Interventional

Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.

NCT05569005
View directory record Official record
Conditions
COPD, Smoking, Tobacco Use
Interventions
THS use, Cigarette, Smoking Abstinence
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
35 Years to 65 Years
Enrollment
715 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
81
States / cities
Brandon, Florida • Cape Coral, Florida • Clearwater, Florida + 41 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2024 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Phase 2 Interventional

Treatment to Quit Smoking

NCT00018161
View directory record Official record
Conditions
Smoking
Interventions
Mecamylamine, Nicotine Patch, Cigarette brand switching
Drug · Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 3, 2026, 3:43 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS

NCT04107779
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions
Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mint ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Menthol ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mango ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Mango ENDS, Switch to Dual-use of JUUL 5% and UB of Combustible Cigarette, Tobacco/Nicotine Abstention, Usual Brand of cigarettes
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
279 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
5
States / cities
Little Rock, Arkansas • Rogers, Arkansas • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2020 · Synced Sep 3, 2026, 3:43 AM EDT