Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 6, 2026, 1:27 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 208 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Circadin Clear all

Conditions: Autism Spectrum Disorder
Interventions: Melatonin and Donepezil, Placebo; Drug · Other
Lead sponsor: Stony Brook University; Other
Eligibility: 4 Years to 17 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Stony Brook, New York

Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Sleep Disorder
Interventions: Counseling, Methylphenidate Hydrochloride, Phototherapy, Placebo Administration, Quality-of-Life Assessment, Sham Intervention, Therapeutic Melatonin; Other · Drug · Procedure
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2028
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Non-visual Photoreception
Interventions: Visible light; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 30 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Major Depressive Disorder
Interventions: light glasses, sham glasses (placebo); Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 60 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
Interventions: Ramelteon, Placebo; Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Sleep
Interventions: Amber Lenses, Placebo Lenses; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 50 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Sleep Disorders
Interventions: Circadin 2/5/10 mg, Placebo; Drug
Lead sponsor: Neurim Pharmaceuticals Ltd.; Industry
Eligibility: 2 Years to 17 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 18
States / cities: Phoenix, Arizona • Miami Lakes, Florida • Orange City, Florida + 14 more

Conditions: Stress, Mental Stress
Interventions: Melatonin 3 MG Oral Tablet, Placebo Oral Tablet; Dietary Supplement
Lead sponsor: Baylor University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Waco, Texas

Conditions: Insomnia
Interventions: Placebo, Rozerem 8mg, Rozerem 8mg in combination with Multi Component Behavior Therapy; Drug · Other
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 64 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Hypoxic Ischemic Encephalopathy
Interventions: Melatonin, Magnetic Resonance Imaging, Pharmacokinetics, Neurological Outcome Assessment; Drug · Other · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: Up to 6 Hours
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2027
U.S. locations: 2
States / cities: Gainesville, Florida • Orlando, Florida

Conditions: Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
Interventions: light exposure; Procedure
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 55 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hot Flashes
Interventions: melatonin 0.5 mg; Drug
Lead sponsor: Scripps Health; Other
Eligibility: 50 Years to 70 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Sleep, Sleep Disturbance, Sleep Hygiene
Interventions: Beam Organics Dream Powder, Beam Organics Dream Powder Extra Strength, Placebo; Dietary Supplement
Lead sponsor: Beam; Industry
Eligibility: 24 Years to 50 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Sleep Disturbance, Sleep Quality
Interventions: 2 mg THC + 2 mg CBN + 2 mg CBG + 10 mg CBD + 1 mg Melatonin, 10 mg THC + 5 mg CBN + 5 mg CBG + 20 mg CBD, 10 mg THC + 20 mg CBN + 5 mg CBG, Stay Asleep Placebo, Fast Asleep Placebo; Dietary Supplement
Lead sponsor: Cannabis Science Innovations, LLC; Industry
Eligibility: 21 Years to 55 Years
Enrollment: 332 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Sarasota, Florida

Conditions: Glucose, Circadian Rhythm, Melatonin, Genes, Light
Interventions: placebo, melatonin, bright light, dim light; Drug · Dietary Supplement · Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 55 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Delirium
Interventions: Melatonin, Placebo; Dietary Supplement · Other
Lead sponsor: Scripps Health; Other
Eligibility: 65 Years to 100 Years
Enrollment: 94 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Concussion, Mild, Concussion, Brain, Pediatric ALL
Interventions: Melatonin 3 MG, Placebo; Drug · Other
Lead sponsor: Children's National Research Institute; Other
Eligibility: 12 Years to 18 Years
Enrollment: 254 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Heart Failure, Sleep Disorders
Interventions: melatonin, placebo; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 35 Years to 75 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Opioid Use Disorder, Sleep Disturbance
Interventions: Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test, Ecological Momentary Assessments, Actigraphy, DLMO, Melatonin Suppression Test; Other · Behavioral · Device
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 80 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Major Depressive Disorder
Interventions: BCI-024: over-encapsulated Buspirone tablet 15 mg QD and BCI-049: over-encapsulated Melatonin tablet 3 mg QD, BCI-024 (Buspirone), Matching placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 142 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 9
States / cities: Garden Grove, California • San Diego, California • Altanta, Georgia + 6 more

Conditions: Sleep Disorders, Circadian Rhythm
Interventions: Melatonin, Methylxanthine, Light Therapy; Drug · Procedure
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 18 Years to 40 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Sleep Disturbance
Interventions: melatonin; Dietary Supplement
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Egg Harbor, New Jersey

Conditions: Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder, Advanced Sleep Phase Syndrome (ASPS), Delayed Sleep Phase Syndrome, Sleep Wake Disorders, Sleep Disorder
Interventions: dim light melatonin onset (DLMO); Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Metabolic Syndrome
Interventions: Melatonin, Placebo; Drug
Lead sponsor: Emory University; Other
Eligibility: 30 Years to 79 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 2
States / cities: Atlanta, Georgia

Search by objective public record fields.

Pilot Study of Sleep Therapy and Biomarkers in Children With Autism Spectrum Disorders

Cognitive Behavioral Therapy and Multimodal Therapy in Treating Sleep Disturbance in Patients With Cancer

Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep

Neurobiological Effects of Light on MDD

Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia

Seeing the World Through Assorted Glasses

Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities

Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress

Effects of Ramelteon (8mg) Alone and in Combination With Multi-Component Behavioral Therapy on Sleep and Circadian Phase in Patients With Chronic Insomnia

Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia

Light Exposure to Treat Sleep Disruption in Older People

Melatonin Effects on Luteinizing Hormone

An Exploratory Investigation of a Supplement to Enhance Sleep Quality and Quantity

A Double-Blind, Randomized, Placebo-Controlled Study of the Safety and Effects of Various Cannabinoids on Sleep Quality

Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2

Melatonin and Sleep in Preventing Delirium in the Hospital

Acute Concussion and Melatonin

Melatonin Supplementation to Improve Sleep in Patients With Heart Failure

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)

Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders

Sleep Quality and Pain Medication Use Following Arthroscopic Rotator Cuff Repair

Validation of Circadian Biomarkers in Patients With Sleep Disorders

Melatonin and the Metabolic Syndrome