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ClinicalTrials.gov public records Last synced Nov 7, 2026, 2:43 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 208 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Circadin Clear all

Conditions: Bipolar Disorder, Circadian Rhythm, Depressive Disorder
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Female only
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1991 – 2000
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Ulcerative Colitis
Interventions: Melatonin, Placebo; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 69 Years
Enrollment: 3 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 2
States / cities: Atlanta, Georgia

Conditions: Bipolar Disorder, Delayed Sleep-Wake Phase Disorder
Interventions: Melatonin, Placebo, Behavioral sleep intervention, Behavioral sleep control; Drug · Other · Behavioral
Lead sponsor: Leslie Swanson; Other
Eligibility: 18 Years to 60 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Sleep Disorders
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1996 – 2000
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Obesity, Metabolic Syndrome
Interventions: olanzapine and melatonin; Drug
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2024
U.S. locations: 1
States / cities: Tacoma, Washington

Conditions: Hypertension
Interventions: Melatonin, Placebo; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Sleep Disorder
Interventions: Natrol; Drug
Lead sponsor: University of Nebraska; Other
Eligibility: 4 Years to 8 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Amyotrophic Lateral Sclerosis ALS
Interventions: Astaxanthin, Protandim, Melatonin, MitoQ; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 2
States / cities: Durham, North Carolina • Philadelphia, Pennsylvania

Conditions: Chronobiology Disorders, Circadian Rhythm Disorders, Sleep Disorders, Circadian Rhythm
Interventions: light exposure; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 21 Years to 30 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Sleep
Interventions: Melatonin sleep lotion, Placebo control lotion; Other
Lead sponsor: University of Redlands; Other
Eligibility: 18 Years to 24 Years
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Redlands, California

Conditions: Burns
Interventions: Melatonin, placebo; Drug · Other
Lead sponsor: Shriners Hospitals for Children; Other
Eligibility: 5 Years to 22 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Jet Lag
Interventions: Hydrocortisone, Melatonin, Placebo; Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Primary Insomnia
Interventions: Neu-P11; Drug
Lead sponsor: Neurim Pharmaceuticals Ltd.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 137 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 9
States / cities: San Diego, California • Hallandale, Florida • South Miami, Florida + 6 more

Conditions: Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
Interventions: melatonin, placebo; Dietary Supplement · Other
Lead sponsor: Natalie Denburg; Other
Eligibility: 56 Years to 85 Years
Enrollment: 230 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2028
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Poor Sleep Quality, Leg Cramps, Nocturnal, Melatonin, Magnesium, Muscle Cramps
Interventions: Magnesium and melatonin based multi-ingredient dietary supplementation, Placebo; Dietary Supplement · Other
Lead sponsor: StudySetGo; Network
Eligibility: 40 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 7
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Palm Beach Gardens, Florida + 4 more

Conditions: Advanced Cancer, Cachexia
Interventions: Graded Resistance Training, Aerobic Exercise, Melatonin, Juven, Atenolol, Ibuprofen; Behavioral · Drug · Dietary Supplement
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2014
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Epilepsy
Interventions: Melatonin, Placebos; Drug
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 6 Years to 11 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Rapid Eye Movement Sleep Behavior Disorder, Parkinson Disease
Interventions: Immediate Release Melatonin, Extended Release Melatonin; Dietary Supplement
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Intraventricular Hemorrhage of Prematurity
Interventions: MLT+EPO, Placebo; Combination Product · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 12 Hours to 2 Months
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: St. Petersburg, Florida • Baltimore, Maryland

Conditions: Cell Migration, Cell Invasion, Exercise Recovery
Interventions: Melatonin, Placebo; Dietary Supplement
Lead sponsor: University of Central Florida; Other
Eligibility: 18 Years to 40 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Unipolar Depression
Interventions: Triple Therapy; Other
Lead sponsor: New York State Psychiatric Institute; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New York, New York

Conditions: Glucose Intolerance, Sleep Deprivation, Sleep
Interventions: Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 20 Years to 40 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: End Stage Renal Disease, Chronic Kidney Disease, Sleep Disorder
Interventions: Melatonin; Drug
Lead sponsor: Southeast Renal Research Institute; Other
Eligibility: 18 Years to 85 Years
Enrollment: 53 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Chattanooga, Tennessee

Conditions: Sleep Problems
Interventions: Not listed
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 4 Years to 9 Years
Enrollment: 58 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 3
States / cities: New York, New York • Portland, Oregon • Houston, Texas

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Effects of Sex Hormones on Circadian Rhythm in Men and Women

Melatonin and Ulcerative Colitis: A Pilot Clinical Trial

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

Circadian Regulation of Sleep in Habitual Short Sleepers and Long Sleepers

Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine

Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study

Melatonin CR for the Treatment of Impaired Sleep Maintenance in 4-8 Year Old Children With Autism Spectrum Disorders

ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments

Light Sensitization Study

Impact of Commercial "Sleep Lotion" on Salivary Melatonin Levels and Sleep Quality in Undergraduates

Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

Sleep Laboratory Study to Investigate the Safety and Efficacy of Neu-P11 in Primary Insomnia Patients

Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps

Multimodal Treatment Strategy for Cancer Cachexia

Pilot Study of Melatonin and Epilepsy

Extended-Release Melatonin in Patients With Rapid Eye Movement Sleep Behavior Disorder

Safety of Erythropoietin and Melatonin for Very Preterm Infants With Intraventricular Hemorrhage

This Repeated Measures Parallel-group Investigation Will Examine the Influence of Short-term Melatonin Supplementation (5mg, 3 x Day for 72 Hours) on Cellular Responses, Functional Performance and Recovery Following an Acute Bout of Dynamic Resistance Exercise in Resistance Trained Men and Women

Out-patient Wake Therapy, Light Therapy and Sleep Phase Advance for Depression

Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction

Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders

Understanding Sleep Problems in Children With Autism Spectrum Disorder