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ClinicalTrials.gov public records Last synced Nov 7, 2026, 5:01 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 208 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Circadin Clear all

Conditions: Obstructive Sleep Apnea
Interventions: Melatonin, Placebo; Dietary Supplement · Other
Lead sponsor: Naomi Deacon; Other
Eligibility: 30 Years to 60 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: San Diego, California

Conditions: Delirium, Melatonin
Interventions: Melatonin; Drug
Lead sponsor: MICE Trial Group; Other
Eligibility: 65 Years and older
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Pueblo, Colorado

Conditions: Postoperative Pain, Delirium, Confusion, Sleep
Interventions: Melatonin, Placebo; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Obesity, Prediabetic State
Interventions: Melatonin, Placebo; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Disorders of Consciousness
Interventions: melatonin; Dietary Supplement
Lead sponsor: Rockefeller University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 1 participant
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Chromosome Disorders
Interventions: Melatonin, Enviro-light artificial light box; Dietary Supplement · Device
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 3 Years to 85 Years
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1998 – 2009
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Migraine, Migraine With Aura, Migraine Without Aura
Interventions: Ramelteon, Placebo; Drug
Lead sponsor: Swedish Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Pregnancy
Interventions: Lighting1, Lighting2; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 35 Years · Female only
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Sleep Disturbance, Total Joint Arthroplasty
Interventions: melatonin 6mg, Placebo; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: 18 Years to 99 Years
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Healthy
Interventions: melatonin, Placebo; Dietary Supplement · Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 35 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Norman, Oklahoma

Conditions: Delirium
Interventions: Melatonin, Placebo; Drug
Lead sponsor: Loyola University; Other
Eligibility: 65 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Improving Cardiometabolic Outcomes in Adults
Interventions: Melatonin 1 mg, Placebos, Meal Timing, NON Meal Timing; Dietary Supplement · Other
Lead sponsor: Northwestern University; Other
Eligibility: 35 Years to 54 Years
Enrollment: 43 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Breastfeeding
Interventions: Not listed
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older · Female only
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Eau Claire, Wisconsin

Conditions: Cardiovascular Risk Factor
Interventions: Melatonin, Placebo; Dietary Supplement · Other
Lead sponsor: University of Delaware; Other
Eligibility: 18 Years to 45 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Poor Sleep Quality
Interventions: Walnut consumption, HCHS consumption; Other
Lead sponsor: Columbia University; Other
Eligibility: 45 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Chronic Kidney Diseases
Interventions: Melatonin, Placebo; Dietary Supplement
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Overweight Adolescents, Sleep, Insulin Sensitivity
Interventions: Circadian/Sleep (C/S); Behavioral
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 14 Years to 19 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Developmental Delay Disorders, Chromosome Deletion, Mental Retardation, Sleep Disorders, Circadian Rhythm, Self Injurious Behavior
Interventions: dTR Melatonin (NIH CC PDS), Phototherapy (Bright Light), Melatonin CR; Drug · Device
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 3 Years to 45 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2018
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Multiple Sclerosis
Interventions: Melatonin, Placebo; Dietary Supplement
Lead sponsor: University of California, San Francisco; Other
Eligibility: 20 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Absorption, Pharmacokinetic
Interventions: Hydration Multiplier + Energy, Hydration Multiplier + Sleep, Energy Comp, Sleep Comp; Dietary Supplement · Other
Lead sponsor: Liquid I.V.; Other
Eligibility: 18 Years to 55 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Raritan, New Jersey

Conditions: Sleep Disorder, Blindness
Interventions: Melatonin; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 5 Years to 20 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Newborn Hypoxic Ischemic Encephalopathy
Interventions: Melatonin, placebo; Drug
Lead sponsor: St. Louis University; Other
Eligibility: 1 Hour to 8 Hours
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Night-eating Syndrome
Interventions: Melatonin, Placebo; Dietary Supplement · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Osteoporosis, Osteopenia
Interventions: Fiber Pill, Melatonin, Strontium citrate, Vitamins D3 and K2; Dietary Supplement
Lead sponsor: Duquesne University; Other
Eligibility: Female only
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Search by objective public record fields.

Effects of Melatonin in Untreated Obstructive Sleep Apnea

Melatonin Use in the Intensive Care Elderly Population

Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery

Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population.

Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury

Melatonin Levels in Smith Magenis Syndrome (SMS)

A Study of a Melatonin Receptor Agonist to Prevent Migraine

Effects of Light on Melatonin and Contractions in Pregnant Women

Randomized Trial Investigating Melatonin Supplementation vs Placebo on Sleep Disturbance Following Total Joint Arthroplasty

The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation

Melatonin for Prevention of Post- Operative Delirium Pilot Study Protocol

Strengthening Circadian Signals

A Study of Melatonin Concentration During Lactation

Melatonin and Salt on Blood Vessel Function

Mechanistic Effect of Walnut Consumption on Sleep Quality

Renal Effects of Melatonin Trial in Chronic Kidney Disease

Improving Sleep Health and Circadian Timing to Support Cardiometabolic Health in Adolescents

Treatment Strategies for Children With Smith-Magenis Syndrome

Melatonin for Sleep in MS

Clinical Study to Compare the Effect of an Oral Rehydration Solution on the Rate of Absorption of Functional Ingredients

Melatonin Studies of Totally Blind Children

Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy

Melatonin Treatment for Night-Eating Syndrome

Melatonin-Micronutrients for Osteopenia Treatment Study