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ClinicalTrials.gov public records Last synced Nov 13, 2026, 7:44 PM EST

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Showing 1–24 of 73 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Citrulline Clear all

Conditions: Bronchopulmonary Dysplasia, Bronchopulmonary Dysplasia Associated Pulmonary Hypertension, Pulmonary Hypertension, Premature Birth, Chronic Lung Disease of Prematurity
Interventions: Enteral L-citrulline; Dietary Supplement
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: Up to 30 Weeks
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Sickle Cell Disease
Interventions: L-citrulline tablets, 1000 mg; Drug
Lead sponsor: Angiogenix; Industry
Eligibility: 10 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Sickle Cell Disease
Interventions: Intravenous citrulline; Drug
Lead sponsor: University of Mississippi Medical Center; Other
Eligibility: 6 Years to 50 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Aging, Endothelial Dysfunction, Senescence
Interventions: COMP-4; Dietary Supplement
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 39 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Exercise Physiology, Nutritional Supplementation
Interventions: Caffeine, L-Citrulline, Exogenous Ketone (Beta-Hydroxybutyrate), placebo beverage; Dietary Supplement · Other
Lead sponsor: St. Louis University; Other
Eligibility: 18 Years to 35 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Menopause, Hypertension
Interventions: L-Citrulline, Placebo; Dietary Supplement
Lead sponsor: Texas Tech University; Other
Eligibility: 50 Years to 70 Years · Female only
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Prehabilitation
Interventions: Prehabilitation Program; Combination Product
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 90 Years
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Austin, Texas

Conditions: MELAS Syndrome
Interventions: L-Citrulline; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Aging
Interventions: L-Citrulline, capsule; Drug
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 90 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Chronic Heart Failure, Pulmonary Disorder, Chronic Obstructive
Interventions: sip feeding with stable isotope infusion; Other
Lead sponsor: Texas A&M University; Other
Eligibility: 20 Years and older
Enrollment: 74 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: College Station, Texas

Conditions: MELAS Syndrome
Interventions: Arginine and citrulline supplementations; Dietary Supplement
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 3 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Asthma, Obesity
Interventions: L-ctirulline, Matching Placebo; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Infant,Premature, Bronchopulmonary Dysplasia, Pulmonary Hypertension
Interventions: L-Citrulline; Drug
Lead sponsor: University of Utah; Other
Eligibility: 14 Days to 3 Months
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Libido, Intimacy, Gastrointestinal Issues
Interventions: Reset, Stay Ready Fiber, Libido, Testosterone supplement; Dietary Supplement
Lead sponsor: 906 CMVI Holdings; Industry
Eligibility: 18 Years to 44 Years · Male only
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Sickle Cell Disease
Interventions: Intravenous (IV) citrulline; Drug
Lead sponsor: Suvankar Majumdar; Other
Eligibility: 18 Years to 25 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Cancer
Interventions: Citrulline, Placebo; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 13 Years to 65 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2007
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Sickle Cell Disease
Interventions: L-citrulline, Placebo; Drug · Other
Lead sponsor: Asklepion Pharmaceuticals, LLC; Industry
Eligibility: 6 Years to 21 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 6
States / cities: Washington D.C., District of Columbia • Coral Gables, Florida • Atlanta, Georgia + 3 more

Conditions: Menopause, Cardiovascular Risk Factor
Interventions: L-Citrulline, Placebo, Glutathione; Dietary Supplement
Lead sponsor: Texas Tech University; Other
Eligibility: 50 Years to 79 Years · Female only
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Premature Newborn, Necrotizing Enterocolitis
Interventions: Citrulline samples; Diagnostic Test
Lead sponsor: University of Miami; Other
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2017
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Bioavailability and AUC
Interventions: Removal from study. In case of adverse event, subject treated for the AE., removal from study; Other
Lead sponsor: Vireo Systems, Inc.; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Raritan, New Jersey

Conditions: Aging, Endothelial Dysfunction, Senescence
Interventions: Supplement with ginger extract, L-citrulline, Paullinia cupana, and muira puama; Dietary Supplement
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 2
States / cities: Los Angeles, California • Santa Monica, California

Conditions: Safety Issues, Tolerance
Interventions: Treatment 1, Treatment 2, Placebo; Dietary Supplement
Lead sponsor: USANA Health Sciences; Industry
Eligibility: 18 Years to 50 Years
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Urea Cycle Disorder
Interventions: Not listed
Lead sponsor: Amgen; Industry
Eligibility: Not listed
Enrollment: 203 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Blue Bell, Pennsylvania

Conditions: Metabolic Syndrome, Menopause
Interventions: L-Citrulline supplementation, Placebo; Dietary Supplement
Lead sponsor: Texas Tech University; Other
Eligibility: 45 Years to 79 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Lubbock, Texas

Search by objective public record fields.

Enteral L Citrulline Supplementation in Preterm Infants - Safety, Efficacy and Dosing

PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease

A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome

COMP-4 Supplementation and Brachial Artery FMD

Effects of Pre-Run Nutritional Supplements During a Fixed-Pace 5 km Treadmill Run

2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension

Application of Ergogenic Aids to the Prehabilitation of Abdominal Cancer Patients Undergoing Cancer Surgery

L-Citrulline Dose Finding Safety Study in MELAS

L-Citrulline and Endothelial Function

Method To Measure Protein Digestion & Absorption

Nitric Oxide Production in MELAS Syndrome

Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia

A Clinical Study to Evaluate the Efficacy of Four Supplements on Improving Readiness for Intimacy

A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell Disease

Chemotherapy Toxicity Reduction Via Urea Cycle Support

A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis

Effect of 4 Weeks of Citrulline and Glutathione Supplementation on Arterial Function

Defining Normal Citrulline Levels as a Diagnostic Tool for Screening of Gastrointestinal Disease in Premature Infants

The Objective of This Study Was to Compare and Quantify the Bioavailability of Citrulline Byproducts in Blood Samples and in Urine Samples After a Single Dose of the Assigned Dietary Supplement. The Treatment Arms Containing the Following Molecules: Citrulline HCL and L-Citrulline,

Effect of a Daily Supplement on Plasma PAI-1 Levels

Safety and Tolerability of 2 Dietary Supplement Beverages Designed to Maintain Healthy Blood Pressure.

Observational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs)

Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome