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ClinicalTrials.gov public records Last synced Nov 15, 2026, 2:08 AM EST

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Showing 49–72 of 73 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Citrulline Clear all

Conditions: Citrullinemia
Interventions: stable isotope infusion; Other
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Hypertension
Interventions: L-citrulline; Dietary Supplement
Lead sponsor: Florida State University; Other
Eligibility: 18 Years to 35 Years · Male only
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Blood Pressure
Interventions: L-citrulline, Placebo; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 14 Years to 40 Years · Female only
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Menopause
Interventions: L-Citrulline, Placebo; Dietary Supplement
Lead sponsor: Texas Tech University; Other
Eligibility: 50 Years to 79 Years · Female only
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Aging
Interventions: Resistance Exercise, 14 g Whey protein, 6.6 g Whey protein + 1.25 g leucine, 4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides, 6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline, Water control; Behavioral · Dietary Supplement · Other
Lead sponsor: University of Illinois at Urbana-Champaign; Other
Eligibility: 20 Years to 79 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Urbana, Illinois

Conditions: Obesity and Overweight, Dysbiosis
Interventions: Watermelon, Belvita Breakfast Sandwich + 12 oz Water; Other
Lead sponsor: Florida State University; Other
Eligibility: 18 Years to 30 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Ketosis Prone Diabetes
Interventions: Citrulline, Alanine; Dietary Supplement
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 20 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Obstructive Pulmonary Disease, Exacerbation Copd
Interventions: Stable isotope infusion, Protein and Fish Oil, Protein and Olive Oil, Carbohydrate and Olive Oil; Other · Dietary Supplement
Lead sponsor: Texas A&M University; Other
Eligibility: 45 Years and older
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Obesity, Pre-hypertension, Hypertension
Interventions: L-citrulline supplementation, Whole Body Vibration Training; Dietary Supplement · Other
Lead sponsor: Florida State University; Other
Eligibility: 50 Years to 70 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Acute Vaso Occlusive Crisis (VOC)
Interventions: L-citrulline, D5 1/2NS; Drug · Other
Lead sponsor: Asklepion Pharmaceuticals, LLC; Industry
Eligibility: 6 Years to 21 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Jackson, Mississippi

Conditions: Hypertension
Interventions: L-citrulline; Dietary Supplement
Lead sponsor: Florida State University; Other
Eligibility: 18 Years to 35 Years · Male only
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Tallahassee, Florida

Conditions: Nutritional Deficiency
Interventions: citrulline, Lemonade; Other
Lead sponsor: Société des Produits Nestlé (SPN); Industry
Eligibility: 18 Years and older
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
Interventions: L-citrulline, Plasmalyte A; Drug
Lead sponsor: Asklepion Pharmaceuticals, LLC; Industry
Eligibility: Up to 18 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 10
States / cities: Birmingham, Alabama • Aurora, Colorado • Chicago, Illinois + 7 more

Conditions: Cardiovascular Diseases, Heart Diseases, Heart Defects, Congenital
Interventions: Citrulline; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: Up to 18 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Bronchopulmonary Dysplasia
Interventions: Intravenous L-Citrulline; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 2 Days to 14 Days
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Excessive Physical Exercise, Unspecified
Interventions: Arginine antioxidant supplements, Placebo; Dietary Supplement
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 50 Years to 75 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Healthy
Interventions: Setria performance blend, Placebo; Dietary Supplement
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 20 Years to 30 Years · Male only
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Postmenopausal, Overweight and Obesity
Interventions: Watermelon; Dietary Supplement
Lead sponsor: Appalachian State University; Other
Eligibility: 50 Years to 75 Years · Female only
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Boone, North Carolina

Conditions: Hypertension, Menopause
Interventions: L-Citrulline, Placebo; Dietary Supplement
Lead sponsor: Texas Tech University; Other
Eligibility: 50 Years to 75 Years · Female only
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Obesity, Surgery
Interventions: Stable isotope infusion; Other
Lead sponsor: Texas A&M University; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Obesity, Very Low Calorie Diet
Interventions: Stable isotope amino acid infusion; Other
Lead sponsor: Texas A&M University; Other
Eligibility: 30 Years and older
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: College Station, Texas

Conditions: Atrial Septal Defect, Ventricular Septal Defect, Atrioventricular Septal Defect
Interventions: Intravenous L-Citrulline, Placebo of Intravenous L-Citrulline; Drug
Lead sponsor: Asklepion Pharmaceuticals, LLC; Industry
Eligibility: Up to 6 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 2
States / cities: St Louis, Missouri • Cincinnati, Ohio

Conditions: Asthma
Interventions: L-Citrulline; Dietary Supplement
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 18 Years to 70 Years
Enrollment: 41 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: Aurora, Colorado • Durham, North Carolina

Conditions: Asthma
Interventions: L-citrulline; Dietary Supplement
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 75 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Search by objective public record fields.

Nitric Oxide Flux and Ureagenesis in Argininosuccinate Synthetase Deficiency (ASSD)(Citrullinemia I)

L-citrulline Supplementation & Cold Exposure

Oral L-Citrulline and ADMA in Pregnancy

Citrulline Supplementation On Vascular Responsiveness and Function in Postmenopausal Women

Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women

Effect of Watermelon on Gut and Cardiometabolic Health

Study of Arginine and Nitric Oxide in Patients With Diabetes

AECOPD and Nutritional Supplementation in COPD

Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition

L-citrulline Injection in Patients Aged 6-21 Years Old with Sickle Cell Disease Presenting with Vaso-Occlusive Crisis (VOC)

L-citrulline Supplementation, Cold Exposure, & Post-Exercise Muscle Ischemia

Dose-response Enteral Citrulline for Normal Healthy Volunteers and Surgery Patients

A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects

Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery

Phase 1 Intravenous Citrulline for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants

The Effects of a Dietary Supplement on Exercise Performance in Healthy Older Adults"

Setria Performance Blend Supplementation

Markers of Atherosclerosis in Overweight, Postmenopausal Women Following Daily Watermelon Consumption

8 Weeks of L-CIT Supplementation and LIRET on Vascular Function in Hypertensive Postmenopausal Women

Omics Profiling of Weight Loss With Bariatric Surgery

Very Low Calorie Diet Weight Loss

Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol

Asthma L-Citrulline Pilot Study

L-Citrulline Supplementation Pilot Study for Overweight Late Onset Asthmatics