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ClinicalTrials.gov public records Last synced Oct 18, 2026, 3:36 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Clear Aligner Clear all

Conditions: Microplastic Exposure
Interventions: Clear Aligner Treatment; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 10 Years to 75 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2035
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Periodontal Inflammation
Interventions: Not listed
Lead sponsor: University of Nebraska; Other
Eligibility: 14 Years to 35 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Malocclusion
Interventions: VPro5 device, Deviation from Standard Tray Wear Time (14 Days); Device · Other
Lead sponsor: Mani Alikhani; Industry
Eligibility: 18 Years to 45 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017
U.S. locations: 4
States / cities: Hoboken, New Jersey • Brooklyn, New York • San Antonio, Texas

Conditions: Malocclusion
Interventions: OrthoPulse 2.0, OrthoPulse 2.1, Invisalign 3.5 Day Wear, Fixed Orthodontic Appliances (Braces); Device
Lead sponsor: Biolux Research Holdings, Inc.; Industry
Eligibility: 11 Years and older
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 6
States / cities: Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona + 3 more

Conditions: Osteogenesis Imperfecta
Interventions: Invisalign; Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 12 Years to 40 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 2
States / cities: Los Angeles, California • Bethesda, Maryland

Conditions: Orthodontic Aligner, Microbial Colonization
Interventions: Thermoformed clear aligner, 3D printed clear aligner TC-85, 3D printed clear aligner TA-28; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Malocclusion, Misaligned Teeth
Interventions: Clear Aligners with Dental Monitoring, Clear Aligners; Device
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 12 Years to 70 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2029
U.S. locations: 4
States / cities: Antioch, Illinois • Chicago, Illinois • Grayslake, Illinois + 1 more

Conditions: Malocclusion
Interventions: SureSmile® Clear Aligners; Device
Lead sponsor: Dentsply Sirona Implants and Consumables; Industry
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 4
States / cities: Fresno, California • Princeton Junction, New Jersey • Huntersville, North Carolina + 1 more

Conditions: Orthodontic Pathological Resorption of External Root, Complication of Personal Oral Hygiene
Interventions: Appliance; Device
Lead sponsor: UConn Health; Other
Eligibility: 12 Years and older
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Farmington, Connecticut

Conditions: Orthodontic Treatment, Tooth Crowding, Orthodontics
Interventions: Aerodentis system, Invisalign clear aligner system; Device
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 12 Years to 60 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Malocclusion
Interventions: Invisalign; Device
Lead sponsor: Align Technology, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 253 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 13
States / cities: Anthem, Arizona • Napa, California • Oakland, California + 10 more

Conditions: Malocclusion
Interventions: Clear Aligner; Device
Lead sponsor: Solventum Orthodontics Corporation; Industry
Eligibility: 14 Years and older
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 9
States / cities: Denver, Colorado • Kennesaw, Georgia • Catonsville, Maryland + 5 more

Conditions: Maxillary Lateral Incisor Malocclusion
Interventions: Incisally-beveled attachment, Gingivally-beveled attachment, Optimized attachment, Horizontal attachment; Device
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 16 Years and older
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Malocclusion
Interventions: Movement Enhancement Technique, Clear Aligner; Device
Lead sponsor: Align Technology, Inc.; Industry
Eligibility: 16 Years to 46 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: San Jose, California

Conditions: Wear, Restoration, Volume Assessment, Clear Aligner Appliance
Interventions: Composite Aligner Attachment; Device
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Orthodontic Appliance Complication
Interventions: Corresponding treatment order in the prescription with Align Technology, Superimposition of final and initial positions of lateral incisors: Predicted model, Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x3mm aligners, Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x4mm aligners, Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x5mm aligners; Device
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 12 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Richmond, Virginia

Search by objective public record fields.

Microplastic Exposure From Clear Aligner Wear (MPE)

Inflammation in Clear Aligners With and Without Attachments

Effect of VPro5 Therapy on Clear Aligner Therapy

OrthoPulse 2.0 and 2.1 Feasibility Evaluation

Clear Aligners for the Treatment of Dental Malocclusion in OI

Microbial Colonization in Three Dimensional (3D) Printed Orthodontic Clear Aligners

Optimizing Orthodontic Appliances Efficiency With Remote Dental Monitoring and Artificial Intelligence Algorithms

A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.

Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment

Assessment of the Efficacy of the Aerodentis System

Primer Aligner Study

Evaluation of Clear Aligner Trays to Straighten Teeth

Effect of Clear Aligner Attachment Design on Extrusion of Maxillary Lateral Incisors

The Use of Clear Aligners With Movement Enhancement Techniques

Split-Mouth Comparison of Invisalign Attachments

Effect of Clear Aligner Attachment Size on Extrusion of Maxillary Lateral Incisors