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Showing 1–16 of 16 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Clear Aligner Clear all
Completed Not applicable Interventional

Effect of Clear Aligner Attachment Size on Extrusion of Maxillary Lateral Incisors

NCT06814262
View directory record Official record
Conditions
Orthodontic Appliance Complication
Interventions
Corresponding treatment order in the prescription with Align Technology, Superimposition of final and initial positions of lateral incisors: Predicted model, Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x3mm aligners, Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x4mm aligners, Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x5mm aligners
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
12 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Clear Aligner Attachment Design on Extrusion of Maxillary Lateral Incisors

NCT04968353
View directory record Official record
Conditions
Maxillary Lateral Incisor Malocclusion
Interventions
Incisally-beveled attachment, Gingivally-beveled attachment, Optimized attachment, Horizontal attachment
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
16 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Primer Aligner Study

NCT02550938
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
13
States / cities
Anthem, Arizona • Napa, California • Oakland, California + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Sep 3, 2026, 1:15 AM EDT
Recruiting Not applicable Interventional

A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.

NCT07290790
View directory record Official record
Conditions
Malocclusion
Interventions
SureSmile® Clear Aligners
Device
Lead sponsor
Dentsply Sirona Implants and Consumables
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Fresno, California • Princeton Junction, New Jersey • Huntersville, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Microbial Colonization in Three Dimensional (3D) Printed Orthodontic Clear Aligners

NCT07143370
View directory record Official record
Conditions
Orthodontic Aligner, Microbial Colonization
Interventions
Thermoformed clear aligner, 3D printed clear aligner TC-85, 3D printed clear aligner TA-28
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 3, 2026, 1:15 AM EDT
Recruiting No phase listed Observational

Inflammation in Clear Aligners With and Without Attachments

NCT07506993
View directory record Official record
Conditions
Periodontal Inflammation
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
14 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 3, 2026, 1:15 AM EDT
Enrolling by invitation Not applicable Interventional

Split-Mouth Comparison of Invisalign Attachments

NCT07215598
View directory record Official record
Conditions
Wear, Restoration, Volume Assessment, Clear Aligner Appliance
Interventions
Composite Aligner Attachment
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of the Efficacy of the Aerodentis System

NCT03421886
View directory record Official record
Conditions
Orthodontic Treatment, Tooth Crowding, Orthodontics
Interventions
Aerodentis system, Invisalign clear aligner system
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Clear Aligner Trays to Straighten Teeth

NCT03141788
View directory record Official record
Conditions
Malocclusion
Interventions
Clear Aligner
Device
Lead sponsor
Solventum Orthodontics Corporation
Industry
Eligibility
14 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
9
States / cities
Denver, Colorado • Kennesaw, Georgia • Catonsville, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 1, 2024 · Synced Sep 3, 2026, 1:15 AM EDT
Recruiting No phase listed Observational

Microplastic Exposure From Clear Aligner Wear (MPE)

NCT06934603
View directory record Official record
Conditions
Microplastic Exposure
Interventions
Clear Aligner Treatment
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
10 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Sep 3, 2026, 1:15 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

OrthoPulse 2.0 and 2.1 Feasibility Evaluation

NCT03683017
View directory record Official record
Conditions
Malocclusion
Interventions
OrthoPulse 2.0, OrthoPulse 2.1, Invisalign 3.5 Day Wear, Fixed Orthodontic Appliances (Braces)
Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
6
States / cities
Chandler, Arizona • Peoria, Arizona • Phoenix, Arizona + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Sep 3, 2026, 1:15 AM EDT
Active, not recruiting Not applicable Interventional

Clear Aligners for the Treatment of Dental Malocclusion in OI

NCT04815564
View directory record Official record
Conditions
Osteogenesis Imperfecta
Interventions
Invisalign
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
12 Years to 40 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Los Angeles, California • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of VPro5 Therapy on Clear Aligner Therapy

NCT03240770
View directory record Official record
Conditions
Malocclusion
Interventions
VPro5 device, Deviation from Standard Tray Wear Time (14 Days)
Device · Other
Lead sponsor
Mani Alikhani
Industry
Eligibility
18 Years to 45 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
4
States / cities
Hoboken, New Jersey • Brooklyn, New York • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 6, 2017 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Use of Clear Aligners With Movement Enhancement Techniques

NCT02087163
View directory record Official record
Conditions
Malocclusion
Interventions
Movement Enhancement Technique, Clear Aligner
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
16 Years to 46 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2020 · Synced Sep 3, 2026, 1:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment

NCT02745626
View directory record Official record
Conditions
Orthodontic Pathological Resorption of External Root, Complication of Personal Oral Hygiene
Interventions
Appliance
Device
Lead sponsor
UConn Health
Other
Eligibility
12 Years and older
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2017 · Synced Sep 3, 2026, 1:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Optimizing Orthodontic Appliances Efficiency With Remote Dental Monitoring and Artificial Intelligence Algorithms

NCT05573308
View directory record Official record
Conditions
Malocclusion, Misaligned Teeth
Interventions
Clear Aligners with Dental Monitoring, Clear Aligners
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
12 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2029
U.S. locations
4
States / cities
Antioch, Illinois • Chicago, Illinois • Grayslake, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 3, 2026, 1:15 AM EDT