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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cocaine HCl Clear all
Completed Phase 2 Interventional Results available

Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1

NCT00218387
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Modafinil, Matching Placebo
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional

Dextroamphetamine as an Adjunct in Cocaine Treatment - 1

NCT00000304
View directory record Official record
Conditions
Cocaine-Related Disorders, Substance-Related Disorders
Interventions
Dextroamphetamine, D-Amphetamine, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Not applicable Interventional Results available

Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1

NCT00249496
View directory record Official record
Conditions
Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
Interventions
Contingency management, Employment Only
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 17, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

FMRI of Stress and Addictive Disorders

NCT01558973
View directory record Official record
Conditions
Cocaine Dependence, Opioid Dependence, Alcoholism, Pathological Gamblers, Adolescents
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
13 Years to 50 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 29, 2016 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Not applicable Interventional

Prize Contingency Management for Cocaine-Dependent Methadone Patients

NCT01401270
View directory record Official record
Conditions
Cocaine Abuse
Interventions
prize contingency management
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional

IV Cocaine Abuse: A Laboratory Model - 1

NCT00000212
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Desipramine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1987 – 1988
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 30, 2015 · Synced Sep 27, 2026, 1:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Leveraging Psychological Autopsies to Accelerate Research Into Stimulant Overdose Mortality

NCT06076564
View directory record Official record
Conditions
Stimulant Overdose, Overdose Accidental, Overdose Cocaine, Overdose Methamphetamine
Interventions
Not listed
Lead sponsor
San Francisco Department of Public Health
Government
Eligibility
18 Years and older
Enrollment
176 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Early Phase 1 Interventional Results available

Imaging the Neurochemistry of Drug Addiction With PET

NCT02817698
View directory record Official record
Conditions
Smoking, Cannabis
Interventions
cannabis
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
3
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

CBT With Disulfiram and Contingency Management

NCT00350870
View directory record Official record
Conditions
Cocaine Abuse
Interventions
disulfiram, Placebo, Placebo plus Contingency Management, Disulfiram plus Contingency Management
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional

Methylphendidate Treatment of Cocaine Dependent Patients With Attention Deficit Hyperactivity Disorder - 3

NCT00015054
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Methylphenidate
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 1999
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Contingency Management Plus Deep Transcranial Magnetic Stimulation for the Treatment of Cocaine Use Disorder

NCT07490600
View directory record Official record
Conditions
Cocaine Use Disorder (CUD)
Interventions
Contingency Management (CM), Transcranial Magnetic Stimulation (TMS) Sham, Transcranial Magnetic Stimulation (TMS) experimental
Behavioral · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional

Risperidone for the Treatment of Cocaine Dependence - 7

NCT00000342
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Risperidone
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1997
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Not listed Not applicable Interventional

Pharmacotherapy for HIV+ Stimulant Dependent Individuals

NCT00599573
View directory record Official record
Conditions
HIV Infections, Cocaine Dependence
Interventions
ondansetron
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 13, 2010 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 1 Interventional Results available

Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder

NCT02537873
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Lorcaserin, Cocaine Intravenous (IV), Placebo comparator
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 59 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional

Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention

NCT04843046
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Cognitive Behavioral Therapy (CBT), Pioglitazone, Placebo
Behavioral · Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 27, 2026, 1:28 PM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1

NCT00100113
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
GBR 12909
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

First in Humans Study of JDTic

NCT01431586
View directory record Official record
Conditions
Cocaine Dependence
Interventions
JDtic
Drug
Lead sponsor
RTI International
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated May 9, 2012 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Combined Treatment for Cocaine-Alcohol Dependence - 1

NCT00218569
View directory record Official record
Conditions
Alcohol Dependence, Cocaine Dependence
Interventions
Naltrexone, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 60 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 26, 2016 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional Results available

Mirtazapine for Treating Cocaine Dependent Individuals Who Also Suffer From Depression

NCT00249444
View directory record Official record
Conditions
Cocaine Dependence, Depression
Interventions
Mirtazapine, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Completed No phase listed Observational

Relapse Patterns in Female Cocaine Users - 4

NCT00000287
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 60 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional

Efficacy and Safety of TV-1380 as Treatment for Facilitation of Abstinence in Cocaine-Dependent Subjects

NCT01887366
View directory record Official record
Conditions
Cocaine Addiction
Interventions
TV-1380 150 mg, TV-1380 300 mg, Placebo
Drug
Lead sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
14
States / cities
Los Angeles, California • Oceanside, California • San Francisco, California + 11 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2015 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Phase 2 Interventional

Serotonin, Impulsivity, and Cocaine Dependence Treatment

NCT00297505
View directory record Official record
Conditions
Cocaine Dependence
Interventions
citalopram
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 27, 2026, 1:28 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Behavioral Effects of Drugs: Inpatient (35)

NCT03519022
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Cocaine, Placebo oral capsule, Methylphenidate
Drug
Lead sponsor
Craig Rush
Other
Eligibility
18 Years to 55 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Sep 27, 2026, 1:28 PM EDT
Recruiting Phase 1Phase 2 Interventional

The Impact of Cobenfy Maintenance on Cocaine's Effects

NCT07624227
View directory record Official record
Conditions
Cocaine Use Disorder (CUD)
Interventions
Cobenfy, Placebo
Drug
Lead sponsor
Joshua A. Lile, Ph.D.
Other
Eligibility
18 Years to 60 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 27, 2026, 1:28 PM EDT