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Showing 1–24 of 117 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Coffee Clear all
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Fresh, Frozen or Lyophilized Fecal Microbiota Transplantation for Multiple Recurrent C. Difficile Associated Diarrhea

NCT02318992
View directory record Official record
Conditions
Recurrent C. Difficile Associated Diarrhea
Interventions
Fecal Microbiota
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Sep 2, 2026, 2:06 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Caffeine on Chess Performance and Cognitive Function in Professional Chess Players

NCT07641335
View directory record Official record
Conditions
Cognitive Performance, Attention, Reaction Time, Caffeine
Interventions
Caffeinated Coffee, Decaffeinated Coffee Placebo
Dietary Supplement
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 50 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimizing Chronic Pain Treatment With Enhanced Neuroplastic Responsiveness

NCT02681081
View directory record Official record
Conditions
Pain, Osteoarthritis
Interventions
Glucose Administration, Intermittent Fasting, Control
Other
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 85 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 14, 2019 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Whole Coffee Cherry Study

NCT04986956
View directory record Official record
Conditions
Effect of Drug
Interventions
Whole coffee cherry extract, Placebo
Dietary Supplement
Lead sponsor
Auburn University
Other
Eligibility
40 Years to 65 Years
Enrollment
323 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Caffeine on Heart Function

NCT02401776
View directory record Official record
Conditions
Fatigue, Tachycardia
Interventions
Monster Energy Drink, Coffee
Dietary Supplement
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 35 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 17, 2016 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional

The Effect of Coffee Consumption in Enhancing Recovery of Bowel Function Following Colorectal Surgery.

NCT02639728
View directory record Official record
Conditions
Postoperative Ileus
Interventions
Regular Coffee, Decaffeinated coffee, Warm water
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of Time-restricted Eating on Weight Loss.

NCT03393195
View directory record Official record
Conditions
Obesity, Insulin Resistance
Interventions
Time-restricted Eating plan, Consistent Meal timing plan
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 64 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 2, 2020 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

NCT05119153
View directory record Official record
Conditions
Hyperglycemia
Interventions
Placebo Comparator, Light Roasted Coffee, Medium Roasted Coffee, Dark Roasted Coffee
Dietary Supplement
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 11, 2021 · Synced Sep 2, 2026, 2:06 AM EDT
Active, not recruiting Not applicable Interventional

A Study of Time Restricted Eating in Obese Adults

NCT05660291
View directory record Official record
Conditions
Overweight
Interventions
Early time-restricted eating, Late time-restricted eating
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 64 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Sep 2, 2026, 2:06 AM EDT
Not listed Not applicable Interventional

The Effects of Specialty Coffee on Cognitive Function in People With Type 2 Diabetes

NCT05709847
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Coffee
Other
Lead sponsor
University of Reading
Other
Eligibility
55 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Caffeine- and Protein-Containing Coffee Beverage on Metabolism and Muscular Performance

NCT04180787
View directory record Official record
Conditions
Exercise Performance, Metabolism
Interventions
Beverage Consumption
Dietary Supplement
Lead sponsor
Texas Tech University
Other
Eligibility
18 Years to 40 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acute Effects of Coffee Beverage on Postprandial Inflammation and Oxidative Stress - A Pilot Study

NCT02174640
View directory record Official record
Conditions
Overweight, Obese, Healthy
Interventions
Coffee, Water
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 45 Years · Female only
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Phase 2 Interventional Results available

Evaluation of Coffee Therapy for Improvement of Renal Oxygenation

NCT03878277
View directory record Official record
Conditions
Type1diabetes, Type1 Diabetes Mellitus, Diabetic Kidney Disease, Juvenile Diabetes, Diabetic Nephropathies, Diabetes Complications, Diabetes, Autoimmune
Interventions
Starbucks® Cold brew - 325ml bottle
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 21 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Single-Arm, Virtual Clinical Trial to Evaluate the Effects of a Sleep Supporting Beverage and Two Coffee Substitute Products

NCT06146517
View directory record Official record
Conditions
Sleep, Mood, Caffeine Withdrawal, Anxiety, Productivity
Interventions
Clevr Sleeptime, Clevr Matcha, Clevr Chai
Other
Lead sponsor
Clevr Blends
Industry
Eligibility
28 Years to 42 Years · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Coffee and Real-time Atrial and Ventricular Ectopy

NCT03671759
View directory record Official record
Conditions
Premature Atrial Contractions, Premature Ventricular Contractions
Interventions
Start: On Caffeine, Start: Off Caffeine
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional

Intermittent Fasting for the Treatment of Type 2 Diabetes Mellitus

NCT05860413
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Intermittent energy restriction (IER), Time Restricted Eating (TRE)
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Phase 2 Interventional Results available

Energy Metabolism in Thyroidectomized Patients

NCT04782856
View directory record Official record
Conditions
Thyroid Goiter, Hypothyroidism, Thyroid Cancer
Interventions
Levothyroxine, Liothyronine, Placebo
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 89 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Sep 2, 2026, 2:06 AM EDT
Active, not recruiting Not applicable Interventional

Time Restricted Eating to Mitigate Obesity in Veterans With Spinal Cord Injury

NCT05921487
View directory record Official record
Conditions
Spinal Cord Injury, Obesity
Interventions
Time Restricted Eating
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 89 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 2, 2026, 2:06 AM EDT
Recruiting No phase listed Observational

Observational Study of Bone Complications in People With Post-menopausal Breast Cancer Who Have Stopped Treatment With Denosumab and Aromatase Inhibitors

NCT05590949
View directory record Official record
Conditions
Breast Cancer
Interventions
Physical Evaluation, Dual-energy X-ray absorptiometry scans, Trabecular Bone Score
Other · Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Phase 2 Interventional Results available

Impact of Periodontal Therapy on Patients With Diabetes

NCT04830969
View directory record Official record
Conditions
Diabetes Mellitus, Type II, Periodontitis
Interventions
Chlorhexidine gluconate oral rinse, Scaling & Root Planing, Soft Picks
Drug · Procedure · Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
25 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Sep 2, 2026, 2:06 AM EDT
Recruiting Phase 1Phase 2 Interventional

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

NCT05692024
View directory record Official record
Conditions
Colorectal Cancer, Coffee, Gastrointestinal Microbiome, Stenosis, Fibrosis, Liver, Ultrasound Elastography, Proton Magnetic Resonance Spectroscopy
Interventions
Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule., Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Fuel and Rhythm (FAR) Phase 2 Study

NCT05482711
View directory record Official record
Conditions
Aging
Interventions
Time Restricted Eating Intervention
Other
Lead sponsor
University of Florida
Other
Eligibility
65 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 2, 2026, 2:06 AM EDT
Recruiting Not applicable Interventional

Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults

NCT06733636
View directory record Official record
Conditions
Olfactory Dysfunction, Smell Loss, Anosmia, Hyposmia
Interventions
Sudoku Puzzles, ScentCare (Olfactory Training Device)
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 2, 2026, 2:06 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)

NCT05413382
View directory record Official record
Conditions
Halitosis
Interventions
Biofresh® 4plus, Placebo
Dietary Supplement
Lead sponsor
Novozymes A/S
Industry
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 9, 2022 · Synced Sep 2, 2026, 2:06 AM EDT