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Showing 1–18 of 18 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD) Clear all
Not yet recruiting Not applicable Interventional

Senyo Health App - Comorbid Alcohol Use Disorder Treatment in Individuals With Bipolar Disorder Using a Telehealth Collaborative Care Platform

NCT07556861
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Senyo Health App
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 29, 2026, 2:13 PM EDT
Active, not recruiting Not applicable Interventional

Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens

NCT05384223
View directory record Official record
Conditions
Substance Use Disorders, PTSD
Interventions
RRFT (Risk Reduction through Family Therapy), ENCOMPASS (Integrated Treatment for Adolescents and Young Adults)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
13 Years to 75 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional Results available

SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)

NCT00265564
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional

Present- Versus Past-focused Therapy for PTSD and Substance Use Disorder

NCT01274741
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Use Disorder, Alcohol Use Disorder
Interventions
Creating Change (CC), Seeking Safety (SS)
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Phase 2 Interventional Results available

The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use

NCT04925570
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Substance Use Disorders
Interventions
W-SUDs, Digitally-delivered Psychoeducation
Device · Other
Lead sponsor
Woebot Health
Industry
Eligibility
18 Years to 65 Years
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional Results available

Pilot: Digital Therapeutic vs Education for the Management of Problematic Substance Use

NCT04974645
View directory record Official record
Conditions
Alcohol Use Disorder (AUD), Substance Use Disorders
Interventions
W-SUDs, Digitally-delivered Psychoeducation
Device · Other
Lead sponsor
Woebot Health
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Palo Alto, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Sep 29, 2026, 2:13 PM EDT
Active, not recruiting Not applicable Interventional

Integrated CBT to Improve Functioning in Veterans With Anxiety and Substance Use

NCT04871100
View directory record Official record
Conditions
Anxiety Disorder, Posttraumatic Stress Disorder, Hazardous Drinking
Interventions
Unified Protocol- Alcohol, Usual care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional

Delivery of Anxiety Disorder Treatment in Addictions Centers

NCT01764698
View directory record Official record
Conditions
Anxiety Disorders, Substance Use Disorders
Interventions
CALM-SUD, Treatment as usual
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Phase 2 Interventional Results available

NAC for Treating Comorbid PTSD and SUD

NCT02911285
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), Substance Use Disorder (SUD)
Interventions
N-acetylcysteine, Placebo, Cognitive behavioral therapy
Drug · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2021 · Synced Sep 29, 2026, 2:13 PM EDT
Enrolling by invitation Not applicable Interventional

Senyo Health With Substance Use Disorder (SUD) in Primary Care

NCT06743282
View directory record Official record
Conditions
Substance Use Disorders, Substance Abuse
Interventions
Senyo App, Follow-up
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional

Evaluating Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD)

NCT05536908
View directory record Official record
Conditions
PTSD, Substance Use Disorders
Interventions
Residential Written Exposure Therapy, Treatment as Usual
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Salem, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder

NCT00399763
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Substance Abuse
Interventions
Atomoxetine, Placebo
Drug
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
12 Years to 19 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 7, 2015 · Synced Sep 29, 2026, 2:13 PM EDT
Active, not recruiting Not applicable Interventional

Examining Feasibility and Acceptability of Telemedicine for Substance Use Disorder (SUD)

NCT04768920
View directory record Official record
Conditions
Substance Use Disorders, Substance Use, Substance Dependence
Interventions
MI-CBT Teletx
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 29, 2026, 2:13 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

NCT07141394
View directory record Official record
Conditions
Homelessness, Substance Use Disorder (SUD)
Interventions
Medication for Addiction Treatment (MAT), Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
7,908 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 29, 2026, 2:13 PM EDT
Recruiting Not applicable Interventional

Combining a Smartphone App With Medications to Manage Heavy Drinking

NCT06303778
View directory record Official record
Conditions
Alcohol Use Disorder (AUD)
Interventions
Stand Down mobile app, Standard Care
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
15
States / cities
Phoenix, Arizona • Fayetteville, Arkansas • Washington D.C., District of Columbia + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2025 · Synced Sep 29, 2026, 2:13 PM EDT
Completed No phase listed Observational

Mindfulness and Meditation-Based Relapse Prevention for Substance Use Disorders

NCT07417579
View directory record Official record
Conditions
Substance Use Disorders, Behavioral Health, Addiction Psychological, Addiction Disorders, Meditation, Mindfulness Based Stress Reduction, Prevention
Interventions
Mindfulness and Meditation-Based Relapse Prevention Program
Behavioral
Lead sponsor
Bout Me Healing
Industry
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional

Affective Management Training for Cannabis Misuse

NCT03432013
View directory record Official record
Conditions
Cannabis Use Disorder
Interventions
CUD-AMT, SUD-CBT
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 25 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 16, 2022 · Synced Sep 29, 2026, 2:13 PM EDT
Completed Not applicable Interventional

CPT for Offenders With SUD

NCT01277939
View directory record Official record
Conditions
Computer-assisted, Evidence-based Psychosocial Intervention, for Substance Abuse Treatment
Interventions
Therapeutic Education System (TES), Standard Care
Behavioral
Lead sponsor
National Development and Research Institutes, Inc.
Other
Eligibility
18 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
10
States / cities
Cañon City, Colorado • Denver, Colorado • Model, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 1, 2013 · Synced Sep 29, 2026, 2:13 PM EDT