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Showing 1–24 of 232 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cognitive Challenge Clear all
Completed No phase listed Observational

Apolipoprotein E (ApoE) and Metabolism

NCT03109561
View directory record Official record
Conditions
Cognitive Function, Healthy
Interventions
Resting State Indirect Calorimetry, ApoE, Metabolism, Cognitive Challenge
Other · Genetic · Diagnostic Test
Lead sponsor
Lance Johnson
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Timeline
2018 – 2020
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 22, 2020 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Wellness Interventions After Transplant Study

NCT00367809
View directory record Official record
Conditions
Organ Transplant
Interventions
Mindfulness-Based Stress Reduction (MSBR), Health Education (HE), Delayed Intervention
Behavioral
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 15, 2008 · Synced Sep 3, 2026, 6:38 AM EDT
Withdrawn Not applicable Interventional

Computerized Cognitive Training for Patients With Epilepsy

NCT03644082
View directory record Official record
Conditions
Epilepsy
Interventions
Luminosity Trial Memory Match, Luminosity Trial Memory Matrix, Luminosity Trial Famliar Faces, Luminosity Trial Brain Shift, Luminosity Trial Star Search, Luminosity Trial Word Bubbles, Luminosity Trial Color Match, Luminosity Trial Ebb and Flow, Luminosity TrialChalk Board Challenge, Luminosiuty Follow that Frog, Luminosity Train of Thought
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Sep 3, 2026, 6:38 AM EDT
Terminated Not applicable Interventional

Reducing Suicide Risk in Older Veterans Using Problem Solving Therapy

NCT04763330
View directory record Official record
Conditions
Suicidal Ideation, Depressive Disorder, Anxiety Disorders, Post Traumatic Stress Disorder
Interventions
Enhanced Usual Care (EUC), Problem Solving Therapy (PST) plus EUC
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
2
States / cities
Palo Alto, California • Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 3, 2026, 6:38 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults

NCT01345864
View directory record Official record
Conditions
Healthy
Interventions
Scopolamine + Donepezil Placebo + PF-04995274 Placebo, Scopolamine + Donepezil 5 mg + PF-04995274 Placebo, Scopolamine + Donepezil 10mg + PF-04995274 Placebo, Scopolamine + Donepezil Placebo + PF-04995274 0.25 mg, Scopolamine + Donepezil Placebo + PF-04995274 15 mg
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 16, 2011 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Effectiveness of Self-Acceptance Group Therapy

NCT02121561
View directory record Official record
Conditions
Shame
Interventions
Self-Acceptance Group Therapy
Behavioral
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jul 1, 2015 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional

Understanding How Cognitive Remediation Works

NCT01683539
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Chronic Mental Disorder, Major Depression, Bipolar Disorder
Interventions
The Thinking Skills for Work Program, The Cognitive Skills for Work Program
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Manchester, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 3, 2026, 6:38 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Gait Adaptation Study

NCT07660601
View directory record Official record
Conditions
Aging
Interventions
Gait Adaptation Training, Basic Physical Training
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 3, 2026, 6:38 AM EDT
Active, not recruiting Early Phase 1 Interventional

Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain

NCT04744883
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Spinal Manipulation Therapy (SMT), Naloxone, Placebo, Mindfulness Based Stress Reduction Therapy (MT)
Other · Drug · Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 3, 2026, 6:38 AM EDT
Active, not recruiting Not applicable Interventional

Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2

NCT06182241
View directory record Official record
Conditions
Cervical Cancer, Hiv
Interventions
Retention in cervical cancer care intervention
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional

Project for Cognitive Advancement in Infants With Neuromotor Disorders

NCT02673658
View directory record Official record
Conditions
Motor Coordination or Function; Developmental Disorder
Interventions
Motor + problem solving, body weight support training
Behavioral
Lead sponsor
Duquesne University
Other
Eligibility
7 Months to 36 Months
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional Results available

RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms

NCT05965752
View directory record Official record
Conditions
Long COVID, Long COVID-19, Long COVID19
Interventions
BrainHQ/Active Comparator Activity, BrainHQ, PASC CoRE, tDCS-active, tDCS-sham
Other · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
328 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
24
States / cities
Phoenix, Arizona • Tucson, Arizona • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Novel Treatment of Emotional Dysfunction in Post Traumatic Stress Disorder (PTSD)

NCT01391832
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Processing Therapy, Repetitive Transcranial Magnet Stimulation (rTMS)
Device · Behavioral
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 60 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2024 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Food Form and Fitness on Appetite and Digestion.

NCT01070199
View directory record Official record
Conditions
High and Increasing Contribution of Energy From Beverages in the Diet May Enhance Positive Energy Balance and Weight Gain
Interventions
liquid to liquid, liquid to solid, solid to liquid, solid to solid
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 24, 2011 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional

Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder

NCT00595387
View directory record Official record
Conditions
Bipolar Disorder, Depression
Interventions
Supportive Psychotherapy, Cognitive Behavioral Therapy (CBT)
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional

Evaluating Process of Change in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for Depression

NCT06245096
View directory record Official record
Conditions
Depression
Interventions
Cognitive Behavioral Therapy, Acceptance and Commitment Therapy
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Life Steps for PrEP for Youth

NCT03805451
View directory record Official record
Conditions
HIV, Pre-exposure Prophylaxis, Medication Adherence
Interventions
Life Steps for PrEP for Youth
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
16 Years to 24 Years · Male only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
3
States / cities
Atlanta, Georgia • Chicago, Illinois • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional

Treatment for Relationships and Safety Together

NCT04816149
View directory record Official record
Conditions
Suicide, Interpersonal Relations
Interventions
VA Standard Suicide Intervention, Treatment for Relationships and Safety Together (TR&ST)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional Results available

CBT-I for Psychosis: Guidelines, Preliminary Efficacy, and Functional Outcomes

NCT02535923
View directory record Official record
Conditions
Insomnia, Psychosis
Interventions
Cognitive Behavioral Therapy-Insomnia, Health and Wellness
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RHBS Brain and Balance Study of Older Adults

NCT04796870
View directory record Official record
Conditions
Cognitive Performance, Balance
Interventions
Online Brain and Balance Training Program
Other
Lead sponsor
George Mason University
Other
Eligibility
55 Years to 80 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 24, 2021 · Synced Sep 3, 2026, 6:38 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Mental Ability Challenge Study in Adults With and Without HIV

NCT03244488
View directory record Official record
Conditions
HIV-1-infection, Aging, Premature, Cognitive Impairment, Memory Impairment, HIV-Associated Cognitive Motor Complex
Interventions
Scopolamine Injectable Product, Mecamylamine Pill
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
35 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 24, 2019 · Synced Sep 3, 2026, 6:38 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Efficacy of the Expectancy Challenge Alcohol Literacy Curriculum on Reducing College Student Alcohol Use and Harms

NCT05616247
View directory record Official record
Conditions
Alcohol Use, Underage, Harmful; Use, Alcohol
Interventions
ECALC, ECALC Plus Weekly Boosters
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 3, 2026, 6:38 AM EDT
Recruiting Not applicable Interventional

Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)

NCT06413173
View directory record Official record
Conditions
Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment, Post Concussive Symptoms
Interventions
Active tDCS and Cognitive Training Intervention, Sham tDCS and Cognitive Training Intervention
Combination Product
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 60 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
San Diego, California • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 3, 2026, 6:38 AM EDT
Completed Phase 2 Interventional Results available

Interpretation Training to Reduce Anxiety: Evaluating Technology-based Delivery Models and Methods to Reduce Attrition

NCT03498651
View directory record Official record
Conditions
Anxiety
Interventions
Cognitive Bias Modification - Interpretation training, Coaching, Online psychoeducation about anxiety
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
1,748 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 18, 2025 · Synced Sep 3, 2026, 6:38 AM EDT