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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cognitive Processing Therapy - PTSD Clear all
Completed Phase 2 Interventional Results available

Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence

NCT01847469
View directory record Official record
Conditions
Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD)
Interventions
Enhanced-Cognitive Processing Therapy-C (E-CPT-C), Zonisamide, Placebo
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 15, 2020 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Phase 3 Interventional Results available

Telemental Health and Cognitive Processing Therapy for Rural Combat Veterans With Posttraumatic Stress Disorder

NCT00879255
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive Processing Therapy Group Videoteleconference, Cognitive Processing Therapy Group In-Person
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older · Male only
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated May 11, 2015 · Synced Sep 25, 2026, 4:35 AM EDT
Completed No phase listed Observational Results available

Cognition and Psychotherapy in PTSD

NCT03641924
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Sep 25, 2026, 4:35 AM EDT
Not listed Not applicable Interventional

Sleep-directed Hypnosis As A Complement To Cognitive Processing Therapy (CPT) In Treating Posttraumatic Stress Disorder (PTSD)

NCT00725192
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive Processing Therapy, Hypnosis
Behavioral
Lead sponsor
Center for Trauma Recovery, St Louis
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 6, 2011 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional

Brief Cognitive Behavioral Treatment of Deployment-Related PTSD Symptoms in Primary Care Settings

NCT02290639
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Brief Cognitive Behavioral Treatment, Minimal Contact
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Lackland Air Force Base, Texas • Randolph Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2016 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional

Group vs. Individual Cognitive Processing Therapy for Combat-related PTSD

NCT02173561
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Group Cognitive Processing Therapy-Cognitive Only, Individual Cognitive Processing Therapy-Cognitive Only
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Mar 26, 2017 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Written Exposure Therapy for Posttraumatic Stress Disorder

NCT01800773
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Written Exposure Therapy, Cognitive Processing Therapy
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Sep 25, 2026, 4:35 AM EDT
Recruiting Not applicable Interventional

Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

NCT06923423
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, PTSD and Alcohol Use Disorder, PTSD and Trauma-related Symptoms, Substance Use Disorder (SUD), Depression, Mental Health, Trauma, Trauma Exposure, Traumatic Stress Disorder, Traumatic Stress, Post Traumatic Stress Symptoms
Interventions
Group Cognitive Processing Therapy (CPT), Control Group Individual trauma focused self-help via workbook
Behavioral
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
640 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
Little Rock, Arkansas • Osceola, Arkansas • Texarkana, Arkansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional

Massed Cognitive Processing Therapy for Combat-related PTSD

NCT03808727
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional

Client-directed Cognitive Processing Therapy

NCT02684994
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
University of Indianapolis
Other
Eligibility
18 Years and older · Female only
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Phase 2Phase 3 Interventional

Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence

NCT00639288
View directory record Official record
Conditions
Alcohol Dependence, PTSD
Interventions
modified CPT-C
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 20, 2016 · Synced Sep 25, 2026, 4:35 AM EDT
Terminated Not applicable Interventional

The Nightmare Augmented Protocol for Treatment of Nightmares in Veterans With PTSD

NCT05120674
View directory record Official record
Conditions
PTSD
Interventions
NAP, CPT, ERRT, Cognitive Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
VA Eastern Kansas
Federal
Eligibility
18 Years to 99 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Leavenworth, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 14, 2021 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional

HIV Prevention and Trauma Treatment in Men Who Have Sex With Men and Who Have a History of Sexual Abuse

NCT00797654
View directory record Official record
Conditions
Risk Reduction
Interventions
Information-motivation-behavior skills and cognitive processing therapy, Pre and Post HIV-Test Counseling
Behavioral
Lead sponsor
Fenway Community Health
Other
Eligibility
18 Years and older · Male only
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 8, 2016 · Synced Sep 25, 2026, 4:35 AM EDT
Recruiting Not applicable Interventional

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

NCT07176273
View directory record Official record
Conditions
Posttraumatic Stress Disorder, PTSD
Interventions
Modular Cognitive Processing Therapy, Modular Prolonged Exposure Therapy, Step Down Treatment, Digital Interventions, Cognitive Processing Therapy (CPT), Prolonged Exposure (PE)
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Augusta, Georgia • Ann Arbor, Michigan • Battle Creek, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 25, 2026, 4:35 AM EDT
Enrolling by invitation Not applicable Interventional

To Drill or Not to Drill: Do Memory Drills Help Train the Ability to "Remember to Remember" in Veterans

NCT06656637
View directory record Official record
Conditions
Memory Deficit
Interventions
Memory Drilling, Compensatory Strategies, Cognitive Processing Therapy
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional Results available

Improving Treatment Outcomes for Suicidal Veterans With PTSD

NCT04690582
View directory record Official record
Conditions
Suicidal Ideation, Suicide, Attempted, Ptsd
Interventions
Cognitive Processing Therapy (CPT), Crisis Response Plan (CRP), Safety Planning Intervention (SPI), Narrative Assessment
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 19, 2024 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional Results available

Enhancement of PTSD Treatment With Computerized Executive Function Training

NCT03260127
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Computerized executive function training plus CPT (CEFT-CPT), Word game training plus CPT (WT-CPT)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 55 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2024 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional

Improving Effectiveness: Treatment Outcome Research

NCT00630578
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
Center for Trauma Recovery, St Louis
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 6, 2011 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional Results available

PTSD Treatment for Incarcerated Men and Women: NIMH

NCT05168267
View directory record Official record
Conditions
PTSD
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 25, 2026, 4:35 AM EDT
Recruiting Not applicable Interventional

Treatment for PTSD and Tinnitus

NCT07106593
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, Posttraumatic Stress Disorder (PTSD), Tinnitus
Interventions
Cognitive Processing Therapy, CBT-t
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional

Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence

NCT02461732
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Dependence
Interventions
Treatment for Integrated Posttraumatic Stress and Substance Use (TIPSS), Cognitive-Behavioral Therapy for Substance Dependence
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Phase 3 Interventional

Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder

NCT02336971
View directory record Official record
Conditions
PTSD, Marital Relationship
Interventions
CBCT for PTSD, Prolonged Exposure
Behavioral
Lead sponsor
Toronto Metropolitan University
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
3
States / cities
Fort Hood, Texas • Fort Sam Houston, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Sep 25, 2026, 4:35 AM EDT
Enrolling by invitation Not applicable Interventional

SMART-CPT for PTSD/Concussion Implementation

NCT06995612
View directory record Official record
Conditions
PTSD, Concussion, Mild
Interventions
SMART-CPT, CPT
Behavioral
Lead sponsor
San Diego Veterans Healthcare System
Federal
Eligibility
18 Years to 55 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2025 · Synced Sep 25, 2026, 4:35 AM EDT
Completed Not applicable Interventional Results available

Cognitive-Behavior Therapy for Posttraumatic Headache

NCT02419131
View directory record Official record
Conditions
Post-traumatic Headache, PTSD
Interventions
Behavioral Headache Therapy, Cognitive Processing Therapy, Treatment as Usual
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 70 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 12, 2024 · Synced Sep 25, 2026, 4:35 AM EDT