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Showing 1–24 of 64 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cognitive Processing Therapy in-person Clear all
Terminated Phase 2 Interventional Results available

Optimal Treatment of Veterans With PTSD and Comorbid OUD

NCT03605342
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Opiate Use Disorder
Interventions
Buprenorphine, Cognitive Processing Therapy (CPT), Individual Drug Counseling (IDC)
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
West Haven, Connecticut • Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Sep 22, 2026, 5:14 AM EDT
Active, not recruiting Not applicable Interventional

EPI-MINN: Targeting Cognition and Motivation - National

NCT05877716
View directory record Official record
Conditions
Psychosis, Psychosis Nos/Other, Schizophrenia, Schizo Affective Disorder, Schizoaffective Disorder, Prodromal Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Schizophreniform Disorders, Major Depression With Psychotic Features, Unspecified Psychosis, Bipolar Disorder
Interventions
Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care
Device · Behavioral · Other
Lead sponsor
University of Minnesota
Other
Eligibility
15 Years to 40 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans

NCT06217575
View directory record Official record
Conditions
Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
Interventions
Alpha neurofeedback training, Visual Attention Training
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
50 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Recruiting Not applicable Interventional

Cognitive Processing Therapy (CPT) Memory Support (MS) Study

NCT05310097
View directory record Official record
Conditions
PTSD
Interventions
CPT, MS
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Jamaica Plain, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness Research in Veterans With PTSD

NCT01928732
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Cognitive Processing Therapy (CPT), Prolonged Exposure (PE)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
916 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
18
States / cities
Tuscaloosa, Alabama • Phoenix, Arizona • Long Beach, California + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2022 · Synced Sep 22, 2026, 5:14 AM EDT
Recruiting Not applicable Interventional

Psychotherapy Effects on Reward Processing in PTSD

NCT06096740
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Diminished Pleasure, Anhedonia, PTSD, Chronic PTSD, Chronic Post-Traumatic Stress Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Behavioral Therapy for the Prevention of Paranoia in Adolescents at High Risk

NCT01923701
View directory record Official record
Conditions
ARMS, APS, Prodromal Symptoms
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
12 Years to 25 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Sep 22, 2026, 5:14 AM EDT
Active, not recruiting Not applicable Interventional

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

NCT06872164
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Opioid Use Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Terminated Not applicable Interventional

Trial of Art Therapy During Cognitive Processing Therapy for PTSD

NCT02610049
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Stress Disorder, Post-Traumatic
Interventions
Cognitive Processing therapy, Art + CPT, CPT + Art Therapy
Behavioral
Lead sponsor
Hampton VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Hampton, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 8, 2017 · Synced Sep 22, 2026, 5:14 AM EDT
Completed No phase listed Observational

Mechanisms of Emotion Regulation Underlying Successful CBT in Depression

NCT04328103
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Cognitive Behavior Therapy (CBT), Nonspecific Supportive Therapy (PBO)
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional

The Effects of Safety Seeking Behaviors During Exposure Therapy for Adults With Spider Phobia

NCT03233113
View directory record Official record
Conditions
Specific Phobia
Interventions
Exposure therapy
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Sep 22, 2026, 5:14 AM EDT
Recruiting Phase 2 Interventional

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

NCT05959434
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Alcohol Use Disorder
Interventions
Cognitive Processing Therapy + Relapse Prevention, Relapse Prevention
Behavioral
Lead sponsor
Texas A&M University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Charleston, South Carolina • College Station, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional Results available

Pilot of Mindfulness Oriented Recovery Enhancement in MethadoneTreatment

NCT03894501
View directory record Official record
Conditions
Opioid Use, Chronic Pain
Interventions
Mindfulness Oriented Recovery Enhancement, Methadone program behavioral treatment as usual
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional

Massed Cognitive Processing Therapy for Combat-related PTSD

NCT03808727
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
VA Boston Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Fort Belvoir, Virginia
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Sep 22, 2026, 5:14 AM EDT
Active, not recruiting Not applicable Interventional

Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis

NCT04518657
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Behavioral Intervention for Physical Activity in MS (BIPAMS), Wellness for MS (WellMS)
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Enrolling by invitation Not applicable Interventional

Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails

NCT07490717
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder, Stimulant Use & Co-occuring Opioid Use Disorders, Co-occurring Mental and Substance Use Disorders, Medications for Opioid Use Disorder
Interventions
Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years and older
Enrollment
338 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Enrolling by invitation Not applicable Interventional

To Drill or Not to Drill: Do Memory Drills Help Train the Ability to "Remember to Remember" in Veterans

NCT06656637
View directory record Official record
Conditions
Memory Deficit
Interventions
Memory Drilling, Compensatory Strategies, Cognitive Processing Therapy
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Sep 22, 2026, 5:14 AM EDT
Recruiting Not applicable Interventional

Multicontext Approach for Cognitive Function in Parkinson Disease

NCT07190404
View directory record Official record
Conditions
PARKINSON DISEASE (Disorder)
Interventions
A metacognitive strategy for cognitive rehabilitation called the Multicontext Approach., Cognitive (Process) Training, MC Approach Booster Session
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
50 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Not listed Not applicable Interventional

The SEMS Project: Staying Employed With MS

NCT03647904
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
SEMS Project
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional

Managing Sleep Symptoms and Modifying Mechanisms of Traumatic Stress

NCT01743339
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Depression, Sleep
Interventions
Cognitive Behavioral Therapy, Control
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 64 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 26, 2017 · Synced Sep 22, 2026, 5:14 AM EDT
Recruiting No phase listed Observational

Computer-based Neurocognitive Assessment in Children With Central Nervous System Tumors Receiving Proton Beam Radiation Therapy

NCT02559752
View directory record Official record
Conditions
Central Nervous System
Interventions
NIH Toolbox Cognitive Battery
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
4 Years to 21 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2032
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional

Group vs. Individual Cognitive Processing Therapy for Combat-related PTSD

NCT02173561
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Group Cognitive Processing Therapy-Cognitive Only, Individual Cognitive Processing Therapy-Cognitive Only
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Fort Hood, Texas
Source: ClinicalTrials.gov public record
Updated Mar 26, 2017 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional Results available

Intensive Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)

NCT01120067
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Intensive Treatment, Treatment as Usual
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
West Haven, Connecticut • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Sep 22, 2026, 5:14 AM EDT
Completed Not applicable Interventional

Cognitive Processing Therapy Versus Its Individual Components in the Treatment of Post-Traumatic Stress Disorder and Depression in Women Who Have Been Sexually Abused

NCT00245232
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Cognitive Therapy, Cognitive Processing Therapy, Written Exposure
Behavioral
Lead sponsor
University of Missouri, St. Louis
Other
Eligibility
18 Years and older · Female only
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 30, 2015 · Synced Sep 22, 2026, 5:14 AM EDT