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Showing 1–24 of 274 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cognitive behavioral therapy for PTSD Clear all
Completed Not applicable Interventional

Cognitive Behavioral Treatment of Posttraumatic Stress Disorder Enhanced by Virtual Reality for Individuals With PTSD and Substance Abuse

NCT00656344
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Substance Abuse
Interventions
Cognitive behavioral treatment enhanced by virtual reality
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 9, 2013 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Phase 3 Interventional Results available

Pharmacologic Treatment of PTSD in Sexually Abused Children

NCT00078767
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Trauma-Focused Cognitive Behavioral Therapy, Sertraline Pill, Placebo Oral Tablet
Behavioral · Drug
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
10 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

RCT of Brief CBT-I in Primary Care Veterans With Suicidal Thoughts

NCT03603717
View directory record Official record
Conditions
Insomnia, Suicidal Ideation
Interventions
Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
3
States / cities
Buffalo, New York • Canandaigua, New York • Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2024 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk

NCT02736929
View directory record Official record
Conditions
PTSD
Interventions
Cognitive Processing Therapy - Cognitive
Behavioral
Lead sponsor
Duke University
Other
Eligibility
40 Years to 65 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2024 · Synced Sep 23, 2026, 8:40 PM EDT
Recruiting Not applicable Interventional

Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

NCT06429293
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive processing therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Sep 23, 2026, 8:40 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Innovative Methods to Assess Psychotherapy Practices (imAPP)

NCT03479398
View directory record Official record
Conditions
Mobile Application-Based CBT Worksheet Collection, Paper-Based Worksheet Collection
Interventions
Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years and older
Enrollment
439 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
4
States / cities
Palo Alto, California • Boston, Massachusetts • Chelsea, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional

PTSD Mobile App for Cancer Survivors

NCT04058795
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Cancer
Interventions
Cancer Distress Coach (CaDC) App, CaDC + mCoaching, mCBT
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
524 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
New York, New York • Durham, North Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Sep 23, 2026, 8:40 PM EDT
Terminated Phase 2 Interventional Results available

Optimal Treatment of Veterans With PTSD and Comorbid OUD

NCT03605342
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Opiate Use Disorder
Interventions
Buprenorphine, Cognitive Processing Therapy (CPT), Individual Drug Counseling (IDC)
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
2
States / cities
West Haven, Connecticut • Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2024 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Phase 1 Interventional Results available

Exposure Therapy for Veterans With PTSD and Panic Attacks (Phase 1)

NCT01551199
View directory record Official record
Conditions
PTSD, Panic Attacks
Interventions
Multiple Channel Exposure Therapy- Veterans
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 64 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Phase 2Phase 3 Interventional

Paroxetine-CR to Treat Post-Traumatic Stress Disorder (PTSD) Symptomatic After Initial Exposure Therapy

NCT00215163
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Cognitive-behavioral therapy and paroxetine-CR
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
4
States / cities
San Diego, California • Boston, Massachusetts • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

Cognitive-Behavioral Conjoint Therapy (CBCT) Project

NCT02720016
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
CBCT-Home Based (CBCT-HB), CBCT-Office Based (CBCT-OB), PTSD Family Education (PFE)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 6, 2022 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional

Written Versus Verbal Brief Cognitive Behavioral Exposure Therapy

NCT04000217
View directory record Official record
Conditions
Written Exposure Therapy, Imaginal Exposure Therapy
Interventions
Written Exposure Therapy, Imaginal Exposure Therapy
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years to 99 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Phase 2Phase 3 Interventional Results available

D-cycloserine and Virtual Reality Exposure to Treat Iraq War Veterans With PTSD

NCT00356278
View directory record Official record
Conditions
Stress Disorder, Post Traumatic
Interventions
D-Cycloserine, Alprazolam, Virtual Reality Exposure Therapy, Placebo
Drug · Behavioral
Lead sponsor
Emory University
Other
Eligibility
21 Years to 65 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Sep 23, 2026, 8:40 PM EDT
Recruiting Not applicable Interventional

TF-CBT for Autistic Youth Pilot Implementation - Open Pilot

NCT07420478
View directory record Official record
Conditions
Autism Spectrum Disorder, PTSD and Trauma-related Symptoms, Autism, Trauma and Stressor Related Disorders, Mental Health Services
Interventions
Trauma-Focused Cognitive Behavioral Therapy, modified for autistic youth
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
6 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

Trauma Survivors Outcomes and Support Study IV

NCT01625416
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury, Alcohol Use, Drug Use
Interventions
Stepped Care Management
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
14 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Web-Based CBT for Women Veterans With PTSD

NCT02917447
View directory record Official record
Conditions
PTSD
Interventions
DESTRESS-WV, Phone Monitoring
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Female only
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 10, 2020 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Behavioral Treatments for Acute Stress Disorder In Firefighters

NCT00183508
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Cognitive behavioral therapy, Psychoeducation
Behavioral
Lead sponsor
Boston University
Other
Eligibility
21 Years to 65 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Sep 23, 2026, 8:40 PM EDT
Recruiting Not applicable Interventional

Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress

NCT07483333
View directory record Official record
Conditions
Trauma Exposure, Trauma, Trauma and Stressor Related Disorder, Mental Health Functioning, Chronic Medical Conditions, Chronic Medical Condition, Chronic Medical Illness, Posttraumatic Stress Disorder PTSD, Posttraumatic Stress Disorders, Posttraumatic Stress Symptoms, Posttraumatic Stress
Interventions
Structured Psychotherapy for Adolescents Responding to Chronic Stress - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Individual, Structured Psychotherapy for Adolescents Responding to Chronic Stress - Individual
Behavioral
Lead sponsor
Anthony Vesco
Other
Eligibility
8 Years to 18 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 23, 2026, 8:40 PM EDT
Active, not recruiting Not applicable Interventional

Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens

NCT05384223
View directory record Official record
Conditions
Substance Use Disorders, PTSD
Interventions
RRFT (Risk Reduction through Family Therapy), ENCOMPASS (Integrated Treatment for Adolescents and Young Adults)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
13 Years to 75 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 23, 2026, 8:40 PM EDT
Recruiting Not applicable Interventional

Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers

NCT05457985
View directory record Official record
Conditions
PTSD
Interventions
Prolonged Exposure for Primary Care (PE-PC), Full Prolonged Exposure, Clinician Supported PTSD Coach App
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
430 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
13
States / cities
Baldwin, Michigan • Battle Creek, Michigan • Flint, Michigan + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional

Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders

NCT07737652
View directory record Official record
Conditions
Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder
Interventions
Microcurrent Neurofeedback (MCN), Standard Care for Substance Use Disorder
Device · Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
18 Years to 65 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional

Peer-led Trauma Therapy for Re-entry

NCT06019767
View directory record Official record
Conditions
PTSD
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional Results available

Group CBT for Aggression in Veterans

NCT02233517
View directory record Official record
Conditions
Aggression, Anger, Posttraumatic Stress Disorder
Interventions
Cognitive Behavioral Therapy, Present Centered Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Sep 23, 2026, 8:40 PM EDT
Completed Not applicable Interventional

Effects of Mindfulness on PTSD

NCT03484390
View directory record Official record
Conditions
Mindfulness, Stress Disorder, Posttraumatic
Interventions
Mindfulness-based stress reduction, Wellness Group
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 1, 2018 · Synced Sep 23, 2026, 8:40 PM EDT