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ClinicalTrials.gov public records Last synced Oct 23, 2026, 10:15 PM EDT

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Showing 385–408 of 479 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Cognitive performance Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans

NCT02360371
View directory record Official record
Conditions
Opioid Sensitivity, Individual Difference, Abuse Opioids
Interventions
Within-subject test of blinded study medication
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Oct 23, 2026, 10:15 PM EDT
Not listed Not applicable Interventional

Rehabilitation of Visual Attention Following mTBI

NCT02719964
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Visual Attention Program (UCR Games), Speech Pathologist-Directed Therapy, General Cognitive Rehabilitation Games (Lumosity)
Other
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 13, 2019 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Cognition in Older Adults With Intermittent Hypoxia and Cognitive Training

NCT03957213
View directory record Official record
Conditions
Aging
Interventions
Acute Intermittent Hypoxia, Computerized Cognitive Training
Device · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 89 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 4, 2022 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Red Spinach Extract Supplementation on Isometric Strength, Resistance Exercise and Cognitive Performance

NCT04292106
View directory record Official record
Conditions
Sports
Interventions
Red Spinach Extract (RSE), Placebo
Dietary Supplement
Lead sponsor
Lipscomb University
Other
Eligibility
18 Years to 34 Years · Male only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 14, 2022 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dose Effect of a Plant Extract on Fatigue

NCT03870126
View directory record Official record
Conditions
Mental Energy, Physical Performance
Interventions
Flavored beverage
Other
Lead sponsor
PepsiCo Global R&D
Industry
Eligibility
18 Years to 49 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Thinking, Walking Outcomes by Type of Exercise

NCT01635348
View directory record Official record
Conditions
Gait Disorder, Sensorimotor, Cognitive Disorder
Interventions
motor skill gait exercise, aerobic gait intervention
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
65 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 23, 2026, 10:15 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neuromodulation of Memory in Aging

NCT05460468
View directory record Official record
Conditions
Mild Cognitive Impairment, MCI
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional

Individualized Cognitive Training in HIV

NCT03122288
View directory record Official record
Conditions
HIV-Associated Cognitive Motor Complex, Aging, Cognitive Impairment, Cognitive Decline, Attention Impaired, Processing, Visual Spatial, Cognitive Deficit in Attention, Cognitive Disorder in Remission
Interventions
Individualized Cognitive Training, No-Contact Control
Behavioral · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
40 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Soy Isoflavone Tablets: Effects on Sleep, Quality of Life, Symptoms and Cognitive Function in Menopausal Women

NCT01401946
View directory record Official record
Conditions
Hot Flashes
Interventions
soy isoflavones, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Female only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2001
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 26, 2011 · Synced Oct 23, 2026, 10:15 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency During NREM Sleep

NCT02945501
View directory record Official record
Conditions
Sleep Deprivation, Mental Competency
Interventions
NeuroConn DC Stimulator PLUS, SHAM TES
Device
Lead sponsor
U.S. Army Medical Research and Development Command
Federal
Eligibility
18 Years to 39 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Phase 2 Interventional Results available

Image Parkinson's Disease Progression Study

NCT02789020
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Rasagiline, Placebo, Magnetic Resonance Imaging, functional Magnetic Resonance Imaging, Physical Function Performance Test
Drug · Other · Device
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 77 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Investigation of How Morning Nutrition Influences Cognitive Performance

NCT03169283
View directory record Official record
Conditions
Cognitive Performance
Interventions
Cereal with B glucan, Cereal without B glucan
Other
Lead sponsor
PepsiCo Global R&D
Industry
Eligibility
18 Years to 44 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional

Feasibility Testing of Cognitive Strategy Training in Post-Concussive Syndrome

NCT04681742
View directory record Official record
Conditions
Brain Concussion, Post-Concussion Syndrome
Interventions
CO-OP Group
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 10, 2023 · Synced Oct 23, 2026, 10:15 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Adaptango Performance PRocess for Older Adults Community reHabilitation

NCT07824128
View directory record Official record
Conditions
Parkinson Disease, Mild Cognitive Impairment, Old Age; Dementia
Interventions
Adaptango Performance Process (APP) program
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional

Training Dual-Task Walking After Stroke

NCT01568957
View directory record Official record
Conditions
Stroke
Interventions
Gait training
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Consumption of 4D Dietary Supplement on Perceptual-Cognitive and Visual-Motor Performance

NCT04988919
View directory record Official record
Conditions
Dietary Supplementation
Interventions
4D, placebo
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 8, 2021 · Synced Oct 23, 2026, 10:15 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

NCT07225400
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
Spatial Navigation training
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Manhattan, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Phase 1 Interventional

Effects of Sage on Memory and Mental Performance in Alzheimer's Disease Patients

NCT00110552
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Salvia officinalis (sage)
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
50 Years to 90 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 29, 2014 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Impact of High Theacrine Doses on Hemodynamic Measures

NCT07376564
View directory record Official record
Conditions
Hemodynamic Measure, Cognitive Performance in Healthy Volunteers
Interventions
Maltodextrin (Placebo), Low dose theacrine, Medium dose theacrine, High dose theacrine
Dietary Supplement
Lead sponsor
Titch Madzima
Other
Eligibility
18 Years to 40 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Elon, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Slow-wave Enhancement in Adults Aged 30-49

NCT04611828
View directory record Official record
Conditions
Sleep
Interventions
Philips SmartSleep
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
30 Years to 49 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Memantine Augmentation of Targeted Cognitive Training in Schizophrenia

NCT04857983
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Memantine, Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 23, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Inspiring Seniors Toward Exercise Promotion

NCT06364189
View directory record Official record
Conditions
Cognitively Normal Older Adults
Interventions
Music, Exercise
Behavioral
Lead sponsor
University of North Carolina, Greensboro
Other
Eligibility
65 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Atlanta, Georgia • Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 23, 2026, 10:15 PM EDT
Terminated Not applicable Interventional

tDCS and Metacognitive Strategy Training in Stroke

NCT05248178
View directory record Official record
Conditions
Chronic Stroke
Interventions
CO-OP Procedures, tDCS, Computer Cognitive Training Procedures, sham tDCS group
Behavioral · Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 85 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 23, 2026, 10:15 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Dual-Task Cost in Bilateral Hearing Loss

NCT05540535
View directory record Official record
Conditions
Bilateral Hearing Loss, Healthy Aging
Interventions
Gait assessment, Cognitive assessment
Other
Lead sponsor
New York University
Other
Eligibility
40 Years and older
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Oct 23, 2026, 10:15 PM EDT