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ClinicalTrials.gov public records Last synced Oct 23, 2026, 5:52 AM EDT

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Showing 193–216 of 479 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Cognitive performance Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight

NCT03786016
View directory record Official record
Conditions
Resilience, Mood, Performance, Stress, Psychological
Interventions
8-Days in an Isolation, Confinement Unit
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 23, 2026, 5:52 AM EDT
Recruiting No phase listed Observational

Integrating Brain, Neurocognitive, and Computational Tools in OUD

NCT06136247
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Neurocognitive battery, fNIRS
Diagnostic Test
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Enrollment
192 participants
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Phase 1 Interventional

Computerized Attention Training for Individuals With Acquired Brain Injury

NCT01641432
View directory record Official record
Conditions
Acquired Brain Injury, Stroke, Hemispatial Neglect
Interventions
Tonic and Phasic Attention Training, Active Comparator
Behavioral
Lead sponsor
Posit Science Corporation
Industry
Eligibility
21 Years to 80 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 22, 2014 · Synced Oct 23, 2026, 5:52 AM EDT
Not listed Phase 2 Interventional

Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder

NCT01466205
View directory record Official record
Conditions
Cognitive Impairments, Schizotypal Personality Disorder
Interventions
DAR-0100A, Placebo
Drug
Lead sponsor
Larry J. Siever
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 20, 2012 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional

Improving Thinking in Everyday Life After Covid-19

NCT04644172
View directory record Official record
Conditions
Covid-19, Cognitive Impairment
Interventions
Speed of Processing Training, Instrumental Activities of Daily Living Shaping, Transfer Package from CI Therapy, Usual Care
Behavioral · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Oct 23, 2026, 5:52 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia

NCT07284290
View directory record Official record
Conditions
Dementia With Lewy Bodies, Parkinson Disease Dementia, Healthy Controls
Interventions
Syn-One skin biopsy, Multi modal MRI, Assessment of dynamic EEG features over 48-hour periods across all study aims, Plasma biomarkers, Galantamine HBr extended-release 8mg capsules (8mg ER).
Procedure · Diagnostic Test · Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
50 Years to 89 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 6, 2026 · Synced Oct 23, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Normative Database and Test-Retest Reliability for BrainCheck Assessments

NCT05497427
View directory record Official record
Conditions
Cognitive Change, Cognitive Decline, Cognitive Deterioration, Neurocognitive Deficit
Interventions
BrainCheck Assessment
Device
Lead sponsor
BrainCheck, Inc.
Other
Eligibility
50 Years and older
Enrollment
1,300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
5
States / cities
Palo Alto, California • Multiple Locations, Connecticut • Austin, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 2, 2026 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Complex, Partnered Martial Arts-based Intervention on Cognitive Processing.

NCT05530148
View directory record Official record
Conditions
Cognitive Change, Processing, Visual Spatial
Interventions
Martial Arts Training Group, Flexing, Toning and Balance
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 45 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2023 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Cognitive Markers in Prodromal MS

NCT05543915
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
Active tDCS
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
23 Years to 59 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Oct 23, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Brain Stimulation Effects on Cognitive Task Performance

NCT05556655
View directory record Official record
Conditions
Cognitive Function
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CAMCI: Advancing the Use of Computerized Screening in Healthcare

NCT03512301
View directory record Official record
Conditions
Cognitive Dysfunction, Cognitive Impairment, Cognitive Decline, Cognitive Change
Interventions
CAMCI, MoCA, Clinical Adjudication
Device · Diagnostic Test
Lead sponsor
Psychology Software Tools, Inc.
Industry
Eligibility
60 Years to 95 Years
Enrollment
773 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
4
States / cities
Indianapolis, Indiana • Sharpsburg, Pennsylvania • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Oct 23, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Active Versus Passive Sitting, Cognition and Energy

NCT07699848
View directory record Official record
Conditions
Electromyography, Pressure Injury of Back
Interventions
Chaircise, Chaircise + Dynamic Leg Exercise, Chaircise + Static Leg Exercise
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 23, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional

iTBS to Enhance Social Cognition in People With Psychosis

NCT06118268
View directory record Official record
Conditions
Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders, Psychosis Nos/Other
Interventions
iTBS (Active), iTBS (Sham)
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 39 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Glen Oaks, New York
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Optimum Omega-3 (003) Diet Study

NCT01642368
View directory record Official record
Conditions
Stress, Physiological
Interventions
The Optimum Omega-3 Fatty Acid Feeding Study
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
18 Years to 40 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 23, 2026, 5:52 AM EDT
Completed No phase listed Observational

Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery

NCT06988176
View directory record Official record
Conditions
Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength, Post Operative Complications, Nutrition Assessment, Risk Assessment, Elderly (People Aged 65 or More), Hand Strength
Interventions
Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
Diagnostic Test
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional

Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia

NCT02488031
View directory record Official record
Conditions
Spinocerebellar Ataxia
Interventions
Error-reduction, International Cooperative Ataxia Rating Scale, Scale for the Assessment and Rating of Ataxia, Beck Depression Inventory, 2nd Ed, Stroop, Purdue Pegboard, Brief Test of Attention, 6-minute Walk, Hand Grip Dynamometer, Montreal Cognitive Assessment, Physical Performance Function, Biomechanical Assessments of Dysmetria, Neurophysiological assessment of brain activity, Biomechanical gait analysis
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 85 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated May 13, 2019 · Synced Oct 23, 2026, 5:52 AM EDT
Not listed No phase listed Observational

Follow-up of MTBI Patients Discharged from the ED Using Standard Clinical Triage Including BrainScope One

NCT04279431
View directory record Official record
Conditions
TBI (Traumatic Brain Injury), Concussion, Brain, MTBI - Mild Traumatic Brain Injury, Closed Head Injury
Interventions
EEG Recording, Neurocognitive Tests, Clinician Evaluation, 22-item CSI
Device · Other
Lead sponsor
BrainScope Company, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
660 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
7
States / cities
Detroit, Michigan • Royal Oak, Michigan • Troy, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing an Online Mindfulness-based Intervention to Reduce Minority Stress and HIV Risk Among Young Adult MSM

NCT05540652
View directory record Official record
Conditions
HIV, Minority Stress, Mental Health Wellness 1
Interventions
Mindfulness-Based Queer Resilience (MBQR)
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 34 Years · Male only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 23, 2026, 5:52 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study

NCT06995638
View directory record Official record
Conditions
Healthy Aging, Alzheimer's Disease (AD)
Interventions
Web-based Cognitive Training (with strategy), Web-based Cognitive Training (without strategy)
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
60 Years to 75 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

NCT03204526
View directory record Official record
Conditions
Parkinson Disease, Cognitive Impairment
Interventions
deep brain stimulation
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Oct 23, 2026, 5:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)

NCT02488863
View directory record Official record
Conditions
Musculoskeletal Pain, Pain, Chronic
Interventions
MRI Neuroimaging, Quantitative Sensory Testing, Questionnaires, Physical and Cognitive Function Testing
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
4
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Phase 1 Interventional

Effects of Sage on Memory and Mental Performance in Alzheimer's Disease Patients

NCT00110552
View directory record Official record
Conditions
Alzheimer Disease
Interventions
Salvia officinalis (sage)
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
50 Years to 90 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 29, 2014 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Results available

Evaluating Two Types of Cognitive Training in Veterans With Schizophrenia

NCT01891721
View directory record Official record
Conditions
Schizophrenia
Interventions
Brain Fitness Program (BFP), Cognitive Package (Cogpack), Commercial Computer Games (Sporcle)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
25 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Los Angeles, California • West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Oct 23, 2026, 5:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family-Based Drug Services for Young Disaster Victims

NCT01859000
View directory record Official record
Conditions
Substance Abuse, Families, Trauma
Interventions
Multidimensional Family Therapy, Group CBT
Other
Lead sponsor
University of Miami
Other
Eligibility
13 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
2
States / cities
Miami, Florida • Luling, Louisiana
Source: ClinicalTrials.gov public record
Updated May 21, 2013 · Synced Oct 23, 2026, 5:52 AM EDT