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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cognitive remediation Clear all
Completed Phase 1 Interventional

Computer-Based Therapy for Mild Cognitive Impairment

NCT00319943
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Computer-based training for Mild Cognitive Impairment (MCI)
Procedure
Lead sponsor
Posit Science Corporation
Industry
Eligibility
65 Years to 90 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2006 · Synced Sep 26, 2026, 5:34 AM EDT
Terminated Phase 2 Interventional

Cognitive REmediation After Trauma Exposure Trial = CREATE Trial

NCT01416948
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Traumatic Brain Injury
Interventions
Methylphenidate Hydrochloride 20 mg, Placebo Capsule, Galantamine 12 mg
Drug
Lead sponsor
INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
7
States / cities
San Diego, California • Boston, Massachusetts • Manchester, New Hampshire + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Sep 26, 2026, 5:34 AM EDT
Recruiting Phase 2 Interventional

Cognitive Remediation Intervention to Prepare for Transition of Care

NCT05336201
View directory record Official record
Conditions
Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy, Health-Related Behavior, Coping Skills
Interventions
CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
10 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 26, 2026, 5:34 AM EDT
Suspended Not applicable Interventional

Cognitive Remediation for Coordinated Specialty Care

NCT03930251
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Clinic-Based Cognitive Remediation, Partial-Remote Cognitive Remediation
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 30 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
9
States / cities
Brooklyn, New York • New York, New York • Queens, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional

Can Cognitive Training Decrease Reactive Aggression?

NCT03623477
View directory record Official record
Conditions
Schizophrenia, Cognitive Deficits, Impulsive Aggression, Emotion, Impulsivity
Interventions
Cognitive Remediation (CRT), CRT+ Social Cognition Training
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 60 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
New York, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Sep 26, 2026, 5:34 AM EDT
Not listed Not applicable Interventional

Cognitive Remediation in Supported Employment at Human Service Center (HSC)

NCT00138021
View directory record Official record
Conditions
Vocational Rehabilitation, Schizophrenia, Mental Disorders, Cognitive Symptoms
Interventions
Computerized cognitive training program
Device
Lead sponsor
Human Service Center, Illinois
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 1, 2007 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional Results available

Specialized Treatment Early in Psychosis (STEP)

NCT00309452
View directory record Official record
Conditions
Schizophrenia and Disorders With Psychotic Features
Interventions
Cognitive Behavioral Group Therapy, Cognitive remediation, Medications, MFG, Assertive case management, Treatment as Usual in the community
Behavioral · Drug · Other
Lead sponsor
Yale University
Other
Eligibility
16 Years to 45 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 7, 2017 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional

Brain-Training Treatment for Long COVID in Older Adults

NCT05705193
View directory record Official record
Conditions
Post-Acute COVID-19 Syndrome
Interventions
NeuroFlex (computerized gamified tasks)
Other
Lead sponsor
UConn Health
Other
Eligibility
60 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional

Confirmatory Efficacy Trial of Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder

NCT03170453
View directory record Official record
Conditions
Autistic Disorder, Autism Spectrum Disorder, Asperger Syndrome, Pervasive Developmental Disorder
Interventions
Cognitive Enhancement Therapy, Enriched Supportive Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
16 Years to 45 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Sep 26, 2026, 5:34 AM EDT
Not listed Not applicable Interventional

Relation of Catechol-O-methyltransferase (COMT) Genotype and Response to Cognitive Remediation Schizophrenia

NCT00664274
View directory record Official record
Conditions
Chronic Schizophrenia
Interventions
Cognitive remediation therapy, COMT Genotyping
Behavioral · Genetic
Lead sponsor
Manhattan Psychiatric Center
Other
Eligibility
18 Years to 55 Years
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Wards Island, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Sep 26, 2026, 5:34 AM EDT
Active, not recruiting Not applicable Interventional

Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)

NCT04143126
View directory record Official record
Conditions
Schizophrenia
Interventions
Cognitive Enhancement Therapy, Enriched Supportive Therapy
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 60 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional

Cognitive Remediation for HIV-associated Neurocognitive Dysfunction

NCT02671526
View directory record Official record
Conditions
HIV-associated Neurocognitive Dysfunction
Interventions
Computerized plasticity-based adaptive cognitive training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
25 Years to 60 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 22, 2016 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional Results available

Hoarding Older Adults

NCT01227057
View directory record Official record
Conditions
Compulsive Hoarding
Interventions
Cognitive Rehabilitation and Exposure Therapy for Compulsive Hoarding, Case Management
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 85 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional Results available

Treatment to Enhance Cognition in Bipolar Disorder

NCT01470781
View directory record Official record
Conditions
Bipolar Disorder, Psychosis
Interventions
BrainWorks, Computer Control
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional

Neuroplasticity-Based Cognitive Remediation for Chemotherapy-Related Cognitive Impairment

NCT04230863
View directory record Official record
Conditions
Cancer Survivors, Chemotherapy-related Cognitive Impairment
Interventions
Neuroplasticity-based Computerized Cognitive Remediation
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
35 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimizing Cognitive Remediation Outcomes in Schizophrenia

NCT02105779
View directory record Official record
Conditions
Schizophrenia, Psychosis
Interventions
Targeted Cognitive Training, Social Cognitive Training
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional

Cognitive Training to Enhance VA Work Program Outcomes

NCT00829400
View directory record Official record
Conditions
Mental Illness, Schizophrenia, Depression, PTSD, Bipolar Disorder
Interventions
Cognitive Remediation, Nintendo Brain Age
Behavioral
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 19, 2018 · Synced Sep 26, 2026, 5:34 AM EDT
Withdrawn Not applicable Interventional

Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Interictal Dysfunction in Epilepsy

NCT02950506
View directory record Official record
Conditions
Epilepsy
Interventions
transcranial direct current stimulation, Cognitive Remediation Therapy
Device · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Saint Louis Park, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 17, 2022 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Phase 3 Interventional

Multicenter Evaluation of Memory Remediation After TBI With Donepezil

NCT02255799
View directory record Official record
Conditions
Traumatic Brain Injury, Memory Deficits
Interventions
Donepezil, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2024
U.S. locations
4
States / cities
Indianapolis, Indiana • Charlestown, Massachusetts • Elkins Park, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional Results available

Nicotinic Enhancement of Cognitive Remediation Training in Schizophrenia

NCT02069392
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
Cognitive remediation training, Nicotine polacrilex lozenge
Behavioral · Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 60 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Sep 26, 2026, 5:34 AM EDT
Terminated Not applicable Interventional

Impact of Individual Cognitive Remediation for Parkinson's Disease

NCT03622840
View directory record Official record
Conditions
Cognitive Impairment, Parkinson Disease
Interventions
Cognitive Remediation
Behavioral
Lead sponsor
New York Institute of Technology
Other
Eligibility
40 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jun 19, 2019 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional

Cognitive Remediation for Schizophrenia

NCT00295048
View directory record Official record
Conditions
Schizophrenia
Interventions
Computer Assisted Cognitive Remediation (CACR)
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
3
States / cities
Baltimore, Maryland • Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 20, 2021 · Synced Sep 26, 2026, 5:34 AM EDT
Completed No phase listed Observational Results available

Optimizing Cognitive Remediation

NCT04395157
View directory record Official record
Conditions
Schizophrenia, Stress Disorders, Post-Traumatic, Generalized Anxiety Disorder, Mood Disorders
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 26, 2026, 5:34 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

GAME Veterans With PTSD Using Computer-Based Cognitive Training

NCT01087775
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Cognitive Training
Behavioral
Lead sponsor
Karen Seal
Federal
Eligibility
18 Years to 40 Years · Male only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 22, 2019 · Synced Sep 26, 2026, 5:34 AM EDT