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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cold Packs Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Cold Therapy Implementation on Multi-modal Postoperative Pain Management

NCT03129464
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Cold therapy via reusable cold gel pack
Device
Lead sponsor
Cleveland Clinic Florida
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Weston, Florida
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Sep 2, 2026, 10:31 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Functional Near-Infrared Spectroscopy and Virtual Reality Relaxation Programs for Pain Management in Patients With Cancer

NCT06456411
View directory record Official record
Conditions
Breast Carcinoma, Kidney Carcinoma, Carcinoma
Interventions
Functional Near-Infrared Spectroscopy, Questionnaire Administration, Virtual Technology Intervention, Cold Stimulation
Procedure · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting Not applicable Interventional

Cold and Compression After Rotator Cuff Repair (RCR)

NCT07516327
View directory record Official record
Conditions
High-grade Partial or Full Thickness Rotator Cuff Tears
Interventions
SOC (Standard of care), Cold and Compression
Other · Device
Lead sponsor
Ochsner Health System
Other
Eligibility
35 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Kenner, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Not applicable Interventional

The Efficacy of Cryotherapy in Pregnancy Related Pelvic Girdle Pain

NCT04469192
View directory record Official record
Conditions
Pelvic Girdle Pain
Interventions
Cryotherapy, Education
Other
Lead sponsor
Loyola University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 9, 2025 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting Not applicable Interventional

External Therapy for Tinnitus Management

NCT07017998
View directory record Official record
Conditions
Tinnitus, Tinnitus, Subjective
Interventions
Cold pack-delivered mild therapeutic hypothermia, Sham (No Treatment)
Device
Lead sponsor
Restorear Devices LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss

NCT06729632
View directory record Official record
Conditions
Noise Exposure, Noise-induced Hearing Loss, Noise; Adverse Effect, Mild Therapeutic Hypothermia, Cooling, Occupational Exposure, Occupational Health, Hidden Hearing Loss
Interventions
Cold pack-delivered mild therapeutic hypothermia
Device
Lead sponsor
Restorear Devices LLC
Industry
Eligibility
18 Years to 55 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Cold Therapy for Pain Control Following Caesarean Section

NCT03711994
View directory record Official record
Conditions
Post Operative Pain
Interventions
Alkantis
Other
Lead sponsor
University of Tennessee
Other
Eligibility
16 Years to 43 Years · Female only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 1, 2022 · Synced Sep 2, 2026, 10:31 PM EDT
Terminated Not applicable Interventional

Cryotherapy in Preventing Peripheral Neuropathy and Nail Toxicity in Patients With Breast Cancer Who Are Receiving Paclitaxel

NCT01243541
View directory record Official record
Conditions
Chemotherapeutic Agent Toxicity, Pain, Peripheral Neuropathy, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer, Therapy-related Toxicity
Interventions
cryotherapy, questionnaire administration, quality-of-life assessment, management of therapy complications, assessment of therapy complications
Procedure · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Vibrating, Cold Device for Pediatric Intravenous (IV) Cannulation Pain Relief

NCT01394250
View directory record Official record
Conditions
Pain, Anxiety
Interventions
Buzzy, Topical Lidocaine 4% Cream
Device · Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
4 Years to 18 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Phase 2Phase 3 Interventional

Chiropractic and Exercise for Low Back Pain in Adolescents

NCT01096628
View directory record Official record
Conditions
Low Back Pain
Interventions
Chiropractic + Exercise, Exercise
Other
Lead sponsor
Northwestern Health Sciences University
Other
Eligibility
12 Years to 18 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Bloomington, Minnesota • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 30, 2014 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Chemical Ice Packs for Cooling Hyperthermic Patients

NCT01694290
View directory record Official record
Conditions
Heat Stroke, Heat Exhaustion
Interventions
Chemical Cold Pack
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years · Male only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 25, 2018 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Not applicable Interventional

Cold Compress for Pain Associated With Intrauterine Device Insertion

NCT02898831
View directory record Official record
Conditions
Intrauterine Device, Cold Compress
Interventions
Cold Compress
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older · Female only
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 17, 2019 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fermented Vegetables and Gut Microbiome Pilot Study

NCT06883994
View directory record Official record
Conditions
Fermented Vegetable Intake, Fermented Vegetable Acceptability, Gut Health, Gut Microbiome, Gastrointestinal Immune Function, Microbiome
Interventions
Fermented vegetable intervention
Other
Lead sponsor
USDA, Western Human Nutrition Research Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Not applicable Interventional

Reduction of Pain Caused by Biologic Drugs in Psoriasis

NCT02168244
View directory record Official record
Conditions
Psoriasis, Pain
Interventions
Heating Pack, Ice pack
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
Not listed
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effectiveness of Emergency Room Protocols for Treating Hyperthermia

NCT07433036
View directory record Official record
Conditions
Hyperthermia
Interventions
Passive cooling, Cooling packs, Ice sheets, Body bag cooling, Cold water immersion
Procedure
Lead sponsor
University of Colorado, Colorado Springs
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)

NCT06456268
View directory record Official record
Conditions
ACL, Opioid Use, Cryotherapy Effect, Vibration; Exposure, Pain, Postoperative
Interventions
VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs
Device
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite

NCT04677712
View directory record Official record
Conditions
Edematous Fibrosclerotic Panniculopathy (EFP), Cellulite
Interventions
CCH-aaes, Compression, Cold Packs, Arnica Gel, INhance®, PDL
Drug · Other
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
8
States / cities
Scottsdale, Arizona • Sacramento, California • San Diego, California + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Not applicable Interventional Results available

Buzzy Versus Vapocoolant Spray: Pediatric Needle Pain Relief

NCT00919100
View directory record Official record
Conditions
Pain
Interventions
Buzzy, vapocoolant
Device · Other
Lead sponsor
Georgia State University
Other
Eligibility
4 Years to 18 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

NCT06293638
View directory record Official record
Conditions
Essential Tremor
Interventions
Alcohol, Alprazolam, Cold Therapy, Peripheral Nerve Stimulation
Drug · Device · Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
30 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury

NCT06841198
View directory record Official record
Conditions
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
Interventions
spinal cord transcutaneous stimulation, Ice testing
Device · Procedure
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Recruiting Not applicable Interventional

Noninvasive Therapy for Tinnitus

NCT07071480
View directory record Official record
Conditions
Tinnitus, Tinnitus, Subjective
Interventions
Cold pack-delivered mild therapeutic hypothermia, Sham device
Device
Lead sponsor
Restorear Devices LLC
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Terminated Not applicable Interventional

Therapeutic Hypothermia After the Return of Spontaneous Circulation

NCT01617291
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Induced therapeutic hypothermia
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2014 · Synced Sep 2, 2026, 10:31 PM EDT
Not yet recruiting Not applicable Interventional

Study of Shunt Flow Under Different Valve Settings Using a Wireless Sensor

NCT07679035
View directory record Official record
Conditions
Hydrocephalus
Interventions
Rhaeos Shunt Monitoring System (RSMS), ShuntCheck III
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
Not listed
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 2, 2026, 10:31 PM EDT
Completed Not applicable Interventional Results available

Pain Rehabilitation Virtual Reality (PRVR): Innovations to Enhance Mobility in the Presence of Pain

NCT04636177
View directory record Official record
Conditions
Chronic Pain, Musculoskeletal Pain, Fibromyalgia, Virtual Reality
Interventions
Pain Rehabilitation Virtual Reality (PRVR), Standard Physiotherapy Rehabilitation (SPR)
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
10 Years to 17 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Menlo Park, California • Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Sep 2, 2026, 10:31 PM EDT