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ClinicalTrials.gov public records Last synced Nov 2, 2026, 9:55 AM EST

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Showing 1–24 of 68 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Cold Pressor Clear all
Completed No phase listed Observational Accepts healthy volunteers Results available

Genetic Variation in Platelet Aggregation

NCT01576536
View directory record Official record
Conditions
Myocardial Infarction
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 45 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 5, 2019 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Stationary Bike Use During Ice Bath and Virtual Reality

NCT05297838
View directory record Official record
Conditions
Pain
Interventions
Stationary Bike, Virtual Reality (VR) Headset, Ice Bath
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 6, 2023 · Synced Nov 2, 2026, 9:55 AM EST
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

L-citrulline Supplementation, Cold Exposure, & Post-Exercise Muscle Ischemia

NCT02104375
View directory record Official record
Conditions
Hypertension
Interventions
L-citrulline
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Mar 10, 2015 · Synced Nov 2, 2026, 9:55 AM EST
Recruiting Phase 3 Interventional Accepts healthy volunteers

Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome

NCT07238465
View directory record Official record
Conditions
Down Syndrome, Autonomic Dysfunction
Interventions
Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia, Head-up Tilt Table Test
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Completed Phase 2 Interventional

Non-Pharmacologic Therapy for Neurocardiogenic Syncope

NCT00096902
View directory record Official record
Conditions
Syncope
Interventions
Tilt table test
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Nov 2, 2026, 9:55 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

NCT05699200
View directory record Official record
Conditions
Spontaneous Coronary Artery Dissection, Healthy
Interventions
Arterial Tonometry, Echocardiogram, Carotid Ultrasounds, Elastography, Ankle-Brachial Index, Microneurography with sympathoexcitatory maneuvers
Other · Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Neural Control of Kidney Blood Flow During Exercise in African American Adults

NCT03981640
View directory record Official record
Conditions
Healthy
Interventions
Acute exercise, Cold pressor test, Mental stress test
Other
Lead sponsor
University of Massachusetts, Boston
Other
Eligibility
18 Years to 35 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Variability in Adrenergic Response

NCT00838695
View directory record Official record
Conditions
Vascular Reaction to Medications
Interventions
Phenylephrine
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 40 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 26, 2018 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Prophylactic Massage Therapy on Pain Tolerance and Threshold

NCT04625335
View directory record Official record
Conditions
Pain
Interventions
No Massage Protocol, Prophylactic Therapeutic Massage
Other
Lead sponsor
Kyle Knight
Other
Eligibility
18 Years to 45 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 12, 2020 · Synced Nov 2, 2026, 9:55 AM EST
Not listed No phase listed Observational Accepts healthy volunteers

Cardiac Magnetic Resonance Imaging for Detecting Endothelial Dysfunction

NCT00808535
View directory record Official record
Conditions
Endothelial Dysfunction, Myocardial Perfusion Abnormalities, Cardiac MRI Perfusion With Vasomotor Stress, Diabetes
Interventions
Cardiac Perfusion MRI w Vasomotor Stress
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2009 · Synced Nov 2, 2026, 9:55 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Endothelin Receptor Function and Acute Stress

NCT02116335
View directory record Official record
Conditions
Hypertension
Interventions
Bosentan, Placebo
Drug
Lead sponsor
Augusta University
Other
Eligibility
18 Years to 50 Years
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Nov 2, 2026, 9:55 AM EST
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Non-Invasive Bioelectronic Analytics

NCT04100486
View directory record Official record
Conditions
Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
Interventions
Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Other · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Influence of Stress on Encoding and Prediction

NCT05920161
View directory record Official record
Conditions
Stress, Learning, Spatial
Interventions
Socially Evaluated Cold Pressor Test, Control
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Results available

Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology

NCT06445712
View directory record Official record
Conditions
Child Development
Interventions
Parental Support Cold Pressor Task
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
6 Years to 9 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

NCT07069478
View directory record Official record
Conditions
CBD, Cannabidiol, Stress, Acute Stress Reaction
Interventions
Stress Intervention
Other
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 70 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Acute Plasma Abeta Responses to Stress

NCT05521919
View directory record Official record
Conditions
Stress Reaction, Stress Physiology
Interventions
Sympathetic Nervous System Activation, No-stress
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Nov 2, 2026, 9:55 AM EST
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

NCT06417177
View directory record Official record
Conditions
Aging, Menopause, Hypoxia, Vasodilation
Interventions
Placebo, Propranolol, Gemtesa
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 70 Years · Female only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

NCT07429292
View directory record Official record
Conditions
Healthy Volunteers, Sympathetic Activity
Interventions
Lidocaine 2%
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes

NCT04858178
View directory record Official record
Conditions
Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic; Hypotension, Neurogenic
Interventions
Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia, Transcutaneous spinal cord stimulation
Diagnostic Test · Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 14, 2023 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Appetite Hormones in Binge Eating Disorder

NCT01552759
View directory record Official record
Conditions
Binge Eating Disorder
Interventions
Postprandial responses, Cold pressor test, Test meal
Procedure · Behavioral
Lead sponsor
New York Obesity and Nutrition Research Center
Other
Eligibility
18 Years to 50 Years
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 11, 2013 · Synced Nov 2, 2026, 9:55 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Noninvasive Measurement of Sympathetic Nerve Activity in Healthy Volunteers

NCT02264262
View directory record Official record
Conditions
Sympathetic Nerve Activity
Interventions
Physiologic maneuvers
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 45 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2020 · Synced Nov 2, 2026, 9:55 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Deciphering Preserved Autonomic Function After Multiple Sclerosis

NCT07012135
View directory record Official record
Conditions
Multiple Sclerosis, Control Subjects, Autonomic Dysreflexia
Interventions
Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

NCT07210411
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Tests of sympathetic inhibition, Tests of above level sympathetic activation, Testing of below level sympathetic activation, Epidural stimulation, Transcutaneous stimulation
Diagnostic Test · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 50 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Nov 2, 2026, 9:55 AM EST
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy

NCT01048125
View directory record Official record
Conditions
Cardiomyopathy
Interventions
Sympathetic Nerve Activity, Mental Stress Test (Color Word Test), The Modified Oxford Technique for Baroreflex Sensitivity, Cold Pressor Test, Echocardiographic evaluation
Device · Behavioral · Drug + 1 more
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
21 Years to 90 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 23, 2016 · Synced Nov 2, 2026, 9:55 AM EST