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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Cold Water Immersion Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Cold Water Exposure and Immune Function Study

NCT06667479
View directory record Official record
Conditions
Cold Water Immersion, Immune Function, Muscular Strength, Mental Health
Interventions
Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS), Control Group (CO)
Other
Lead sponsor
University of Northern Colorado
Other
Eligibility
18 Years to 45 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Greeley, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wearable Focused Ultrasound Stimulation for Peripheral Nerve Pain Management

NCT07160049
View directory record Official record
Conditions
Pain Management, Peripheral Neuropathic Pain
Interventions
Cold Pressor Task - Upper Limb, Algometry Pain Tests in the Upper Limb, Algometry Pain Tests in the Lower Limb
Device
Lead sponsor
Evan (Huiliang) Wang
Other
Eligibility
20 Years to 40 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cooling Strategies for Older Adults in the Heat

NCT06349616
View directory record Official record
Conditions
Aging
Interventions
Intermittent cold-water hand and forearm immersion, No intermittent cold-water hand and forearm immersion
Other
Lead sponsor
Penn State University
Other
Eligibility
65 Years to 100 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Sep 2, 2026, 4:43 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Cold Water Exposure's Effects on Physical and Mental Health

NCT06667193
View directory record Official record
Conditions
Cold Exposure
Interventions
Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS)
Other
Lead sponsor
University of Northern Colorado
Other
Eligibility
18 Years to 45 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Greeley, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Sep 2, 2026, 4:43 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress

NCT04060966
View directory record Official record
Conditions
Healthy
Interventions
Cold-Pressor Task (CPT), Control CPT, fMRI
Behavioral · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 64 Years
Enrollment
397 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Results available

A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)

NCT03687970
View directory record Official record
Conditions
Chemotherapy-induced Peripheral Neuropathy
Interventions
Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory, Diode Laser fiber type Selective Stimulator, Quantitative sensory testing, Conditioned pain modulation efficiency, Spontaneous pain at baseline on 0-10 Numerical Rating Scale (NRS)
Other · Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 18, 2021 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Pre-exercise Beta-hydroxy-beta-methylbutyrate Free Acid (HMB-FA) and Cold Water Therapy for the Attenuation of Muscle Damage and Soreness

NCT01793779
View directory record Official record
Conditions
Muscle Damage
Interventions
cold water immersion, beta-hydroxy-beta-methylbutyrate free acid (HMB-FA), Placebo
Procedure · Dietary Supplement
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 31, 2013 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Prevention and Treatment of Immersion Pulmonary Edema

NCT00815646
View directory record Official record
Conditions
Immersion Pulmonary Edema (IPE), Swimming Induced Pulmonary Edema (SIPE)
Interventions
Sildenafil
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 2, 2026, 4:43 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Thermodynamic Exposure and Sleep in Military Cadets

NCT07201935
View directory record Official record
Conditions
Cold-water Immersion, High Heat Sauna, Combination of Cold-water Immersion and High Heat Sauna
Interventions
Cold Water Immersion, High Heat Sauna
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 30 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Cold Water Immersion Modulates Reinforcing Effects of Nitrous Oxide - 2

NCT00000250
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
0% N2O, 40% N2O
Drug
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 32 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1993 – 1995
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effect of Cold Water Immersion on Recovery and Performance in NCAA Division I Athletes

NCT06565468
View directory record Official record
Conditions
Recovery, Physiological, Athletic Performance
Interventions
Cold water immersion pool.
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold

NCT06784531
View directory record Official record
Conditions
Cold Exposure
Interventions
Mitoquinone mesylate (MitoQ), Placebo, Cold Water Hand Immersion, Cold Air Exposure
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
18 Years to 40 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cold Water Immersion Stirring in Hyperthermic Individuals

NCT04613843
View directory record Official record
Conditions
Hyperthermia
Interventions
Water Stirring, No Water Stirring
Other
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years to 39 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Sep 2, 2026, 4:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effectiveness of Emergency Room Protocols for Treating Hyperthermia

NCT07433036
View directory record Official record
Conditions
Hyperthermia
Interventions
Passive cooling, Cooling packs, Ice sheets, Body bag cooling, Cold water immersion
Procedure
Lead sponsor
University of Colorado, Colorado Springs
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

The Brain Alerting Mechanism Study

NCT02050386
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Cold pressor stimulation, Sham Stimulation
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 95 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2016 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Effect on Attention Using an Ipad Game App

NCT03115788
View directory record Official record
Conditions
Cognitive Function
Interventions
Heat induced pain, Cold Induced Pain, iPad
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Body Cooling in Hyperthermic Males and Females

NCT04190264
View directory record Official record
Conditions
Cryotherapy Effect
Interventions
Thermal Rehabilitation Machine, Cold Water Immersion
Device · Other
Lead sponsor
University of North Carolina, Greensboro
Other
Eligibility
18 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Greensboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 7, 2020 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Modulation Effectiveness (PME)

NCT05783362
View directory record Official record
Conditions
Healthy People
Interventions
Conditioned Pain Modulation (CPM)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Sep 2, 2026, 4:43 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Characterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function

NCT04419831
View directory record Official record
Conditions
Pain Response, Stress, Trauma
Interventions
Yale Stress Pain Test (YSPT)
Diagnostic Test
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Sep 2, 2026, 4:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury

NCT06841198
View directory record Official record
Conditions
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
Interventions
spinal cord transcutaneous stimulation, Ice testing
Device · Procedure
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Exploring Pain Modulation With TMS and Repeated Pain Conditioning in Healthy Individuals

NCT06726018
View directory record Official record
Conditions
Healthy Adult
Interventions
Conditioned Pain Modulation (CPM)
Behavioral
Lead sponsor
Priyanka Rana, PT, MPT, PhD
Other
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Endometriosis and Migraine

NCT06785129
View directory record Official record
Conditions
Migraine, Endometriosis
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Conditioned pain modulation (CPM) response, Hormonal assessment
Device · Behavioral · Biological
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pain Modulatory Profiles in Stretching

NCT05891353
View directory record Official record
Conditions
Healthy
Interventions
Cold Water Immersion, Pain Inducing Stretch, Pain Free Stretch
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 2, 2026, 4:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Sensitivity During Puberty

NCT05145595
View directory record Official record
Conditions
Pain
Interventions
Thermal Sensory Analyzer, Pressure Stimuli, Mechanical Stimuli, Pain Ratings, Thermal pain thresholds, Pressure pain thresholds (PPT), Mechanical temporal summation, Conditioned pain modulation (CPM) efficiency, Offset analgesia efficiency, Cold pain tolerance
Device · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
9 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 2, 2026, 4:43 PM EDT