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ClinicalTrials.gov public records Last synced Oct 22, 2026, 6:08 PM EDT

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Showing 73–96 of 120 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Cold temperature Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Investigating the Effects of Beef Consumption on Cognitive and Brain Health

NCT06690892
View directory record Official record
Conditions
Dietary Intervention, Dietary Proteins, Dietary Assessment, Cognitive Ability, General
Interventions
Ready-to-eat beef in frozen, 5-oz packages, Ready-to-eat beef in frozen, 1-oz packages
Dietary Supplement
Lead sponsor
University of Nebraska Lincoln
Other
Eligibility
19 Years to 24 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Active, not recruiting Not applicable Interventional

A Study of RhinAer Stylus for Treating Chronic Rhinitis

NCT06599736
View directory record Official record
Conditions
Chronic Rhinitis
Interventions
RhinAer Stylus
Device
Lead sponsor
Aerin Medical
Industry
Eligibility
22 Years to 85 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Colorado Springs, Colorado • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Completed Phase 4 Interventional

Ziconotide as First-Line IDT

NCT03321955
View directory record Official record
Conditions
Neuropathic Pain
Interventions
Ziconotide 100 MCG(microgram)/ML Intrathecal Solution, Quantitative sensory testing, Serum markers: Interleukin-1, Interleukin-6, and tumor necrosis factor
Drug · Diagnostic Test
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Oct 22, 2026, 6:08 PM EDT
Recruiting Early Phase 1 Interventional

The Hysterosalpingogram (HSG) Experience And Tubal Spasm (HEAT) Study

NCT07226310
View directory record Official record
Conditions
Infertility
Interventions
Warmed HSG
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Not listed Not applicable Interventional

Can Hypothermia be Incorporated Into Primary Angioplasty for Heart Attack?

NCT00763828
View directory record Official record
Conditions
ST-Elevation Myocardial Infarction
Interventions
Life Recovery Systems ThermoSuit
Device
Lead sponsor
Life Recovery Systems
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 10, 2023 · Synced Oct 22, 2026, 6:08 PM EDT
Completed Not applicable Interventional Results available

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

NCT01615484
View directory record Official record
Conditions
Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis, Bronchiectasis, Sarcoidosis, Pulmonary Hypertension, Alpha-1 Antitrypsin Deficiency
Interventions
Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
Procedure · Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 8, 2018 · Synced Oct 22, 2026, 6:08 PM EDT
Completed Not applicable Interventional Results available

Sous Vide Rewarming for Frostbitten Extremities

NCT04633174
View directory record Official record
Conditions
Frostbite, Frostbite of Hand, Frostbite of Foot
Interventions
Sous Vide Device (SVD)
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
Not listed
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 22, 2026, 6:08 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Exploring Pain Modulation With TMS and Repeated Pain Conditioning in Healthy Individuals

NCT06726018
View directory record Official record
Conditions
Healthy Adult
Interventions
Conditioned Pain Modulation (CPM)
Behavioral
Lead sponsor
Priyanka Rana, PT, MPT, PhD
Other
Eligibility
18 Years to 75 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation

NCT07297823
View directory record Official record
Conditions
Exercise
Interventions
Cold temperature, Room Temperature
Other
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

The Brain Alerting Mechanism Study

NCT02050386
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Cold pressor stimulation, Sham Stimulation
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 95 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Dec 19, 2016 · Synced Oct 22, 2026, 6:08 PM EDT
Not yet recruiting Not applicable Interventional

Precise Cooler for Donor Heart Transport

NCT07354763
View directory record Official record
Conditions
Heart Transplantation
Interventions
Organ transport using SherpaPak, Ryobi cooler for Organ Transport
Device
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
Not listed
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain Modulation Effectiveness (PME)

NCT05783362
View directory record Official record
Conditions
Healthy People
Interventions
Conditioned Pain Modulation (CPM)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 22, 2026, 6:08 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

The Role of Environmental Temperatures in Respiratory Control

NCT07470086
View directory record Official record
Conditions
Work of Breathing
Interventions
Thermoneutral temperature environment, Cold temperature environment, Hot temperature environment
Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 40 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2028 – 2029
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Completed Not applicable Interventional Results available

Multicenter Sous Vide Frostbite

NCT05280301
View directory record Official record
Conditions
Frostbite, Frostbite of Hand, Frostbite of Foot
Interventions
Sous Vide Device (SVD)
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
Not listed
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Oct 22, 2026, 6:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Limb Cooling in Essential Tremor

NCT02067702
View directory record Official record
Conditions
Essential Tremor
Interventions
Limb Cooling Assessment of ET
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 95 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 18, 2019 · Synced Oct 22, 2026, 6:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neck Cooling as a Non-Invasive Method to Lower Brain Temperature in Healthy Adults

NCT04973085
View directory record Official record
Conditions
Healthy
Interventions
Cold circulated water, Body-temperature circulated water
Device
Lead sponsor
University of Vermont
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Oct 22, 2026, 6:08 PM EDT
Not yet recruiting No phase listed Observational

CT-guided Pudendal Nerve Cryoneurolysis for Palliation of Malignancy-induced Pelvic Pain

NCT06110065
View directory record Official record
Conditions
Malignancy-induced Pelvic Pain
Interventions
CT-guided Pudendal Nerve Cryoneurolysis, Percutaneous image-guided cryoneurolysis
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 31, 2023 · Synced Oct 22, 2026, 6:08 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers

NCT03415243
View directory record Official record
Conditions
Common Cold
Interventions
Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg, Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
21 Years to 45 Years · Male only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Oct 22, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional

Cold Water Irrigation Therapy as an Adjunct to Indomethacin for Post-Endoscopic Retrograde Cholangiopancreatography(ERCP) Pancreatitis

NCT07330284
View directory record Official record
Conditions
Pancreatitis, ERCP Surgery
Interventions
Cold water, Warm water
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
20 Years and older
Enrollment
950 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Not yet recruiting Not applicable Interventional

Study of Shunt Flow Under Different Valve Settings Using a Wireless Sensor

NCT07679035
View directory record Official record
Conditions
Hydrocephalus
Interventions
Rhaeos Shunt Monitoring System (RSMS), ShuntCheck III
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
Not listed
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Recruiting Not applicable Interventional

Cryoablation vs Lumpectomy in T1 Breast Cancers

NCT05505643
View directory record Official record
Conditions
Breast Cancer, Breast Neoplasm
Interventions
Endocare SlimLine Cryoprobe, Lumpectomy
Device · Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
50 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2033
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Recruiting Phase 2 Interventional

Resistant Potato Starch to Alleviate GWI

NCT05820893
View directory record Official record
Conditions
Gulf War Illness
Interventions
Resistant Potato Starch
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 22, 2026, 6:08 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Efficacy of Pharmacological Stimulation of BAT and WAT in Lean and Obese Young Adults

NCT02354807
View directory record Official record
Conditions
Brown Fat
Interventions
Mirabegron, Cold exposure
Drug · Other
Lead sponsor
Otto Muzik
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 22, 2026, 6:08 PM EDT
Not listed Not applicable Interventional

Mental Practice Protocol With Severe Upper Extremity Hemiparesis

NCT05519306
View directory record Official record
Conditions
Stroke, Upper Extremity Paresis
Interventions
Mental Practice
Behavioral
Lead sponsor
Adventist HealthCare
Other
Eligibility
18 Years to 90 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 7, 2022 · Synced Oct 22, 2026, 6:08 PM EDT