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Showing 1–21 of 21 matching trials from the live ClinicalTrials.gov search.
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Completed Not applicable Interventional Accepts healthy volunteers

Pain Sensitivity During Puberty

NCT05145595
Conditions
Pain
Interventions
Thermal Sensory Analyzer, Pressure Stimuli, Mechanical Stimuli, Pain Ratings, Thermal pain thresholds, Pressure pain thresholds (PPT), Mechanical temporal summation, Conditioned pain modulation (CPM) efficiency, Offset analgesia efficiency, Cold pain tolerance
Device · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
9 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Completed Not applicable Interventional Results available

Sous Vide Rewarming for Frostbitten Extremities

NCT04633174
Conditions
Frostbite, Frostbite of Hand, Frostbite of Foot
Interventions
Sous Vide Device (SVD)
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
Not listed
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Non-Invasive Bioelectronic Analytics

NCT04100486
Conditions
Autonomic Dysfunction, Autonomic Imbalance, Autonomic Nervous System Diseases, Vagus Nerve Autonomic Disorder
Interventions
Standing-Squatting-Standing Test, Deep Breathing Test, Cold Pressor Test, Cold Face Test, Valsalva Maneuver, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Other · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 60 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Recruiting No phase listed Observational Accepts healthy volunteers

Endometriosis and Migraine

NCT06785129
Conditions
Migraine, Endometriosis
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Conditioned pain modulation (CPM) response, Hormonal assessment
Device · Behavioral · Biological
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Completed Not applicable Interventional Results available

Multicenter Sous Vide Frostbite

NCT05280301
Conditions
Frostbite, Frostbite of Hand, Frostbite of Foot
Interventions
Sous Vide Device (SVD)
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
Not listed
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Lebanon, New Hampshire
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine

NCT05738213
Conditions
Migraine
Interventions
Thermal stimuli, Pressure stimuli, Pain ratings, Pressure pain thresholds (PPT), Conditioned pain modulation (CPM) response, PedMIDAS (Pediatric Migraine Disability Assessment), Hormonal assessment, Pubertal status
Device · Behavioral · Diagnostic Test + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
11 Years to 15 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating VR Therapy Using Cold Pressor Test

NCT03268863
Conditions
Pain
Interventions
Virtual Reality, Cold Pressor
Device · Other
Lead sponsor
Janet Vittone
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Scottsdale, Arizona • Rochester, Minnesota
Recruiting Not applicable Interventional Accepts healthy volunteers

Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

NCT03258580
Conditions
Normal Physiology, Healthy Volunteers, Pain
Interventions
Medoc thermal stimulator, Electric shock stimulator, Cold water bath, Pain assessment performance feedback
Device · Behavioral
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years to 60 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Bethesda, Maryland
Recruiting No phase listed Observational

Endometriosis Pain

NCT06101303
Conditions
Pelvic Pain, Endometriosis
Interventions
Psychophysical assessment, Psychophysical assessments of experimental pain, Blood, urine and saliva samples, Biopsy and surgery-related data.
Other · Behavioral · Diagnostic Test + 1 more
Lead sponsor
Washington University School of Medicine
Other
Eligibility
12 Years to 45 Years · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
St Louis, Missouri
Completed No phase listed Observational Accepts healthy volunteers

Impact of Cerebellar Mass Resection on Pain Processing

NCT02261649
Conditions
Cerebellar Neoplasm
Interventions
Medoc Advanced Medical Systems PATHWAY Model ATS, Cold water bath, MRI scanner, Questionnaires
Device · Procedure · Other
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
6 Years to 38 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Waltham, Massachusetts
Conditions
Analgesic Response
Interventions
morphine sulfate, hydrocodone, hydromorphone HCI, oxycodone, buprenorphine, oral tablet placebo, sublingual tablet placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
20 Years to 50 Years · Male only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Los Angeles, California
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Brown Adipose Tissue Activation on Insulin Sensitivity in Humans

NCT01791114
Conditions
Insulin Sensitivity, Obesity
Interventions
Cold exposure, Cold exposure plus propranolol, Thermoneutral Conditions, Cold water consumption, Tepid water consumption, Exercise, Meal consumption
Other
Lead sponsor
Rutgers University
Other
Eligibility
18 Years to 75 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Galveston, Texas
Recruiting Not applicable Interventional Accepts healthy volunteers

Migraine in Adolescents

NCT05654012
Conditions
Migraine
Interventions
MRI, Thermal Stimuli, Pressure stimuli, Pain ratings, Pressure pain thresholds (PPT), Conditioned pain modulation (CPM) efficiency, Hormonal assessment, Migraine-related measures, Neural assessments, Pubertal status
Device · Behavioral · Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
10 Years to 13 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Completed Not applicable Interventional Accepts healthy volunteers Results available

Influence of Stress on Encoding and Prediction

NCT05920161
Conditions
Stress, Learning, Spatial
Interventions
Socially Evaluated Cold Pressor Test, Control
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Recruiting Not applicable Interventional

Response to Massage in Neck Pain

NCT06224829
Conditions
Neck Pain
Interventions
Pain Inducing Massage, Pain Free Massage, Cold Water Bath
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Chemotherapy-induced Peripheral Neuropathy
Interventions
Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory, Diode Laser fiber type Selective Stimulator, Quantitative sensory testing, Conditioned pain modulation efficiency, Spontaneous pain at baseline on 0-10 Numerical Rating Scale (NRS)
Other · Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Recruiting Not applicable Interventional Accepts healthy volunteers

Pain in Juvenile Arthritis

NCT07217782
Conditions
Juvenile Idiopathic Arthritis
Interventions
Pressure pain thresholds (measured in kilopascal), Cold pain tolerance (duration in seconds)
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
9 Years to 17 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2035
U.S. locations
1
States / cities
St Louis, Missouri
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effectiveness of Emergency Room Protocols for Treating Hyperthermia

NCT07433036
Conditions
Hyperthermia
Interventions
Passive cooling, Cooling packs, Ice sheets, Body bag cooling, Cold water immersion
Procedure
Lead sponsor
University of Colorado, Colorado Springs
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Colorado Springs, Colorado
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Migraine and CVD Risk in Women

NCT03081390
Conditions
Migraine
Interventions
Mixed meal tolerance testing, Skin conductance & cold pressor test, Flow-mediated dilation testing
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stress, Sex, and the Generalization of Fear

NCT03786952
Conditions
Psychological Stress
Interventions
Stress immediately before learning in males, Sham control immediately before learning in males, Stress 30 minutes before learning in males, Sham control 30 minutes before learning in males, Stress immediately before learning in females, Sham control immediately before learning in females, Stress 30 minutes before learning in females, Sham control 30 minutes before learning in females
Behavioral
Lead sponsor
Ohio Northern University
Other
Eligibility
18 Years and older
Enrollment
606 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ada, Ohio
Completed No phase listed Observational Accepts healthy volunteers

The Effects of Water Temperature on the Cold Pressor Test

NCT03083626
Conditions
Chronic Pain
Interventions
Cold pressor test
Other
Lead sponsor
Georgetown University
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Washington D.C., District of Columbia